Vol 9, No 3 (2015)

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Full Issue

ORIGINAL INVESTIGATIONS

ANALYSIS OF PHYSICAL INACTIVITY AMONG THE WORKING POPULATION OF RYAZAN REGION (ACCORDING TO THE STUDY MERIDIAN-RO)

Filippov Е.V., Petrov V.S.

Abstract

Objective: to study the levels of PA and its relationship with other risk factors among the working population of the Ryazan Region.
Material and methods. The MERIDIAN­RO study was conducted as a prospective cohort with cross­sectional and retrospective study in­ cluded a sample of biochemical, ECG and a survey using a standardized questionnaire. The level of physical activity was assessed by ques­ tionnaire CINDI and then was revised by questionnaire IPAQ. In a study from 2011 it included 1,622 people (in 1220 – a city, 402 – village) aged 25–64 years (mean age – 43,4 ± 11,4 years), of which 42.6 % were male, 53.8 % – female.
Results. The level of low PA in the Ryazan Region, measured by questionnaire IPAQ was 22.9 % (24.3 % in urban and 18.4 % in rural areas, p = 0.014). With multinomial logistic regression were established association between the PA and the low presence of higher education (OR 3.63; 95 % CI 2,26–5,85, p = 0.0001, Wald 28.172), smoking (OR 1.32, 95 % CI 1,01–1,72, p = 0.045, Wald 4,031) and elevated levels of Lp (a) more than 30 mg/dl (OR 1.38, 95 % CI 1,04–1,83, p = 0.024, Wald 5.119). It was also revealed a high demand for advice on improving the PA (74.5 %). Conclusion. The low level of PA in the Ryazan Region, as measured by the IPAQ questionnaire was 22.9 % (24.3 % in urban and 18.4 % in rural areas, p = 0.014), which is lower than Russian average. High demand for advice on improving the FA and created conditions for in­ creasing its level in the region indicate the need to intensify work among the population in this area. 

The Clinician. 2015;9(3):22-27
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VASCULAR WALL STIFFNESS IN PATIENTS WITH ANKYLOSING SPONDYLITIS: RESULTS OF A MULTICENTER STUDY

Gaydukova I.Z., Maslyansky A.L., Polyanskaya O.L., Kolesova E.P., Rebrov A.P., Konradi A.O.

Abstract

Objective: to study some vascular wall stiffness parameters in patients with ankylosing spondylitis (AS) without clinically manifest cardio­ vascular diseases.
Subjects and methods. One hundred and six patients with AS and 21 healthy volunteers without cardiovascular diseases who were matched for age, gender, and cardiovascular risk were examined at two centers. Cardiovascular risk and vascular wall stiffness (augmentation index and pulse wave propagation velocity (PWPV)) were assessed by oscillography. 
Results. Vascular wall stiffness was comparable in the patients with AS (at both centers) and in the healthy individuals. PWPV was 7.45 (5.4–8.71) m/sec in the AS patients (n = 106) and 8.53 (6.28–9.5) m/sec in the healthy individuals (n = 21); the aortic augmentation in­ dex was 15.6 (7.9–31.1) and 21.1 (10.2–24) %, respectively; p > 0.05 for all. Correlation analysis revealed associations between aug­ mentation index, age, blood pressure, disease activity (BASDAI) and spine mobility (BASMI) scores. 
Conclusion. The vascular wall stiffness did not differ between AS patients without cardiovascular diseases and cardiovascular risk­matched healthy individuals. Its parameters were related to age, blood pressure, and disease activity (BASDAI) and axial skeleton immobility (BASMI) indices. 

The Clinician. 2015;9(3):28-33
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ANALYSIS OF OUTPATIENT PHYSICIANS, PRESCRIPTION OF DISAGGREGANT THERAPY FOR PATIENTS AFTER ACUTE MYOCARDIAL INFARCTION AND/OR CORONARY ANGIOPLASTY WITH STENT IMPLANTATION WITHIN THE RECVAD REGISTRY

Zagrebelnyi A.V., Martsevich S.Y., Lukyanov M.M., Pereverzeva E.G., Vorobyev A.N., Yakushin S.S., Boitsov S.A.

Abstract

Objective: to estimate the quality of antiaggregants therapy in patients with coronary heart disease in outpatient settings.
Materials and methods. The data of the retrospective outpatient RECVAD registry (3690 patients who lived in Ryazan and its Region and had evidence in their outpatient medical records for one of the diagnoses, such as coronary heart disease, hypertension, chronic heart failure, atrial fibrillation, or their concurrence, were used. Forty­nine patients after acute myocardial infarction (AMI) and/or percutaneous coro­ nary interventions (PCI) with stenting ≤ 1 year before their inclusion in the registry, who were to undergo dual antiaggregant therapy (DAT) according to current clinical guidelines (CG), were identified among 427 patients after AMI and/or PCI with coronary angioplasty. Contra­ indications to DAT were simultaneously revealed and a relationship of the use of therapy to their presence was compared.
Results.
Among the 49 patients who had indications for DAT that was used in 15 (30.6 %) cases and that was not in 3 (6.1 %) patients in the presence of contraindications, 25 (51.0 %) did not receive DAT in the absence of contraindications and 6 (12.3 %) patients received the therapy in the presence of contraindications.
Conclusion. DAT prescribed by outpatient physicians does not always meet the current CG. There are cases of not using DAT in the presence of obvious indications for DAT and, on the contrary, those of its use in the presence of contraindications. 

The Clinician. 2015;9(3):34-39
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24-HOUR ARTERIAL STIFFNESS PROFILE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND CHRONIC HEART FAILURE

Borodkin A.V., Karoli N.A., Rebrov A.P.

Abstract

Objective: to study the specific features of arterial stiffness (AS) in patients with chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) as evidenced by 24­hour monitoring.
Subjects and methods. A total of 111 patients with COPD, including 76 with signs of CHF, were examined. The patients with COPD and CHF were divided into 2 groups according to the presence or absence of prior myocardial infarction (MI). A BPLab МнСДП­2 apparatus was used to study 24­hour AS monitoring readings. 
Results. The patients with COPD and CHF were noted to have higher values of AS index (ASI) (during a day, daytime) and pulse wave propa­ gation velocity (during a day, daytime, nighttime) than those with COPD without CHF. There was an association between ASI and major car­ diovascular risk factors (hypertension, age, body mass index). The patients with COPD, CHF, and prior MI, unlike those without the latter, were found to have an increased augmentation index throughout the follow­up (during both daytime and nighttime). In the patients with CHF without prior MI, the diurnal ASI was considerably greater than that in both the COPD patients without CHF and those with CHF and prior MI.
Conclusion. Increased vascular wall stiffness was detected in the patients with COPD and CHF. By taking into account pronounced AS changes not only during daytime and nighttime hours, it is reasonable to perform 24­hour AS monitoring in patients with comorbidities in order to obtain more objective results. 

The Clinician. 2015;9(3):40-45
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LECTION

NON-RHEUMATIC MYOCARDITIDES

Shostak N.A., Klimenko A.A., Shemenkova V.S., Loginova T.K.

Abstract

The Clinician. 2015;9(3):46-51
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CASE REPORT

IMPULSIVE-COMPULSIVE DISORDERS IN PARKINSON'S DISEASE. CLINICAL CASES

Fedorova N.V., Nikitina A.V.

Abstract

The Clinician. 2015;9(3):52-56
pages 52-56 views

REVIEW

CURRENT POSSIBILITIES OF ANTICOAGULANT THERAPY IN PATIENTS WITH ATRIAL FIBRILLATION

Gilyarov M.Y., Konstantinova E.V., Trukhin A.I.

Abstract

The Clinician. 2015;9(3):15-21
pages 15-21 views

EDITORIAL

PHYSICAL ACTIVITY AND ITS IMPORTANCE FOR THE PREVENTION OF CARDIOVASCULAR DISEASES

Yakushin S.S., Filippov E.V.

Abstract

Lack of physical activity (PA) is today one of the most important risk factors for atherosclerosis­related deaths. Its level is falling worldwide. A study in the UK, USA, India, Brazil and China (45 % of the world population) total PA declined in these countries and will continue to fall over the next 15 years. In Russia, the level of the PA population decreased. PA is responsible for 12.2 % of the global burden of myo­ cardial infarction. These more than 40 observational studies demonstrate the complete proofs of the linear relationship between the level of PA and total mortality in younger and older men and women. The minimum threshold PA, which can reduce the risk of all­cause mortal­ ity is at a level of 2.5–5 hours a week. Further increase of the PA (its duration and/or intensity) leads to a further reduction of risks. PA should take most days of the week and have a duration of more than 10 minutes a day. Only then did she summed up. In patients with cardiovascular disease to determine the necessary level of PA is difficult. Therefore, before the training they have to undergo stress testing. The program of training should be determined on the basis of findings and the clinical status. Even brief moderate and/or intense exercise can reduce the risk of death of the patient. If an individual does not reach the target of 150 minutes of moderate PA per week, but has been a regular, his risk of CHD was significantly reduced (14 %, 95 % CI 0.76–0.97). The development of programs to improve the PA of the population can have a significant impact on the overall and cardiovascular mortality. 

The Clinician. 2015;9(3):10-14
pages 10-14 views