THE EFFECT OF FOOD ON CLINICAL SYMPTOMS AND INTRAGASTRIC ACIDITY IN DUODENAL ULCER

Objective: to evaluate the effect of food on the clinical symptoms of duodenal ulcer (DU) and postprandial changes in intragastric acidity.

Materials and methods. 52 patients with uncomplicated and 56 – with a complicated course of DU in the acute stage were examined. The control group consisted of 50 apparently healthy individuals. All of the subjects completed a questionnaire including questions about food preferences and the effect of food on the clinical symptoms of the disease. Also, all patients conducted 24-hour pH-metry. We calculated basic parameters and postprandial gastric acidity in the stomach.

Results. Patients with DU are characterized by night snacks, ignore breakfast, a rare use of the first course, rare use of soup, roughage and fresh fruit, which provoke pain or dyspepsia in patients with DU. The decrease postprandial pH and reducing the time consumtion found in patients with DU, especially pronounced in complicated course of the disease, compared with healthy volunteers.

Conclusions. Frequent meals, night snacks, food avoidance “dry rations” and fresh vegetables, fruits typical for patients with DU. Also characteristic of complicated PUD decrease actions alkalizing food, short and low postprandial rise pH.

1. Denisova E.V., Nazarov V.E. Analysis of longterm dynamics of morbidity of ulcer disease before and after introduction to the treatment of eradication therapy. Gastroenterologiya Sankt-Peterburga = Gastroenterology of Saint Petersburg 2011;(2–3):8–10. (In Russ.).

2. Vavrinchuk S.A., Kosenko P.M., Chernyshov D.S. Modern aspects of surgical treatment of perforated ulcers of the duodenum. Khabarovsk: IPKSZ, 2013. (In Russ.).

3. Axon A.T. Relationship between Helicobacter pylori gastritis, gastric cancer and gastric acid secretion. Adv Med Sci 2007;52:55–60. PMID: 18217390.

4. Teves P.M., Ventura S.S., Salgado E.M. Characteristics of gastroduodenal ulcers in patients with negative biopsies for Helicobacter pylori. Act Gastroenterol Latinoam 2010;40(1):40–5. PMID: 20446395.

5. Koveshnikov A.I., Kolesnikova I.Yu. Alkalizing effect of food and duodenogastric reflux in peptic ulcer disease. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii = Russian Journal of Gastroenterology, Hepatology, Coloproctology 2016;26(5)(Suppl. 48):21. (In Russ.).

6. Ivashkin V.T., Maev I.V., Maevskaya M.V. et al. Diseases of the gastrointestinal tract and the hepatobiliary system through the prism of lifestyle in modern society. Rossiyskie meditsinskie vesti = Russian Medical News 2014;(4):75–9. (In Russ.).

7. Gorshkov V.A., Zhigalova T.N., Avalueva E.B. Hydrochloric acid secretion and acid-proteolytic activity of the stomach in vivo. Eksperimental’naya i klinicheskaya gastroenterologiya = Experimental and Clinical Gastroenterology 2005;(1):78–84. (In Russ.).

8. Gorshkov V. A., AvaluevaE. B., ShabalinaM. O. Nutrition and acidproteolytic invasion of the stomach in duodenal ulcer. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii = Russian Journal of Gastroenterology, Hepatology, Coloproctology 2000;10(1):29–33. (In Russ.).

9. Vomero N.D., Colpo E. Nutritional care in peptic ulcer. Arq Bras Cir Dig 2014;27(4):298–302. DOI: 10.1590/S0102-67202014000400017.

10. Paisley J., Beanlands H., Goldman J. et al. Dietary change: what are the responses and roles of significant others? J Nutr Educ Behav 2008;40(2):80–8. DOI: 10.1016/j.jneb.2007.04.374.

11. Storonova O.A., Trukhmanov A.S. Practical doctor about long intragastric pH-metry. Handbook for the doctor. Ed. V.T. Ivashkin. Moscow: ID “Medpraktika-M”, 2012. (In Russ.).

12. Zazgornik J., Mittermayer H. Citric acid inhibits growth of Helicobacter pylori in vitro: a new strategy for eradication. Wien Klin Wochenschr 2011;123(1–2):38–40. DOI: 10.1007/s00508-010-1524-9.

13. Esiev R.K., Zakaeva R.Sh., Plieva A.G. The effect of stomach acid on the pH of saliva and oral cavity. In vol.: Actual problems of chemistry, biology and biotechnology. Moscow, 2016. (In Russ.).