Возможная роль мутаций митохондриального генома при ишемической болезни сердца
https://doi.org/10.17650/1818-8338-2013-2-6-13
Аннотация
Митохондрии являются не только основными производителями аденозинтрифосфата, но и эндогенным источником активных форм кислорода. Митохондриальная дисфункция играет ключевую роль в запуске и прогрессировании атеросклеротического поражения. Нарушение функций митохондрий вследствие повышения в них уровня окисленных форм кислорода, накопления повреждений митохондриальной ДНК, истощения дыхательных цепей вызывает дисфункцию и апоптоз эндотелиальных клеток, активацию матриксных металлопротеиназ, рост сосудистых гладкомышечных клеток и их миграцию в интиму, экспрессию молекул адгезии и окисление липопротеинов низкой плотности. Митохондриальная дисфункция может быть важным объединяющим механизмом, объясняющим атерогенное действие основных факторов риска сердечно-сосудистых заболеваний. Небольшие клинические пилотные исследования показали ассоциацию различных мутаций митохондриального генома с атеросклеротическим поражением артерий. Учитывая появившиеся данные о возможной роли митохондрий в атерогенезе, в настоящее время ведутся разработки новых лекарственных препаратов, оказывающих влияние на функцию митохондрий.
Об авторах
Л. А. Егорова
ФГБУ «Российский кардиологический научно-производственный комплекс» Минздрава России
Россия
Россия
М. В. Ежов
ФГБУ «Российский кардиологический научно-производственный комплекс» Минздрава России
Россия
Россия
Г. М. Шиганова
ГБУЗ «Городская поликлиника № 2» Департамента здравоохранения г. Москвы
Россия
Россия
А. Ю. Постнов
ФГБУ «Российский кардиологический научно-производственный комплекс» Минздрава России
Россия
Россия
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Рецензия
Для цитирования:
Егорова Л.А., Ежов М.В., Шиганова Г.М., Постнов А.Ю. Возможная роль мутаций митохондриального генома при ишемической болезни сердца. Клиницист. 2013;7(2):6-13. https://doi.org/10.17650/1818-8338-2013-2-6-13
For citation:
Egorova L.A., Ezhov M.V., Shiganova G.M., Postnov A.Yu. POSSIBLE ROLE OF MITOCHONDRIAL GENOME MUTATIONS IN CORONARY HEART DISEASE. The Clinician. 2013;7(2):6-13. (In Russ.) https://doi.org/10.17650/1818-8338-2013-2-6-13
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