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БОЛЬ В СПИНЕ, АССОЦИИРОВАННАЯ С ДЕГЕНЕРАЦИЕЙ МЕЖПОЗВОНКОВОГО ДИСКА: МОРФОЛОГИЧЕСКИЕ, ГЕНЕТИЧЕСКИЕ И КЛИНИКО-ИНСТРУМЕНТАЛЬНЫЕ АСПЕКТЫ

https://doi.org/10.17650/1818-8338-2011-2-13-19

Аннотация

Одной из причин возникновения боли в спине является дегенеративное поражение позвоночника. Клинические варианты болевого синдрома и выраженность воспалительных изменений в телах позвонков зависят от активности провоспалительных цитокинов. Скорость развития и прогрессирования дегенеративных изменений структур позвоночного столба генетически детерминирована. Терапия болевого синдрома, ассоциированного с дегенеративной болезнью диска, может включать применение методов восстановления структуры поврежденного межпозвонкового диска, а также использование различных комбинаций противовоспалительных и анальгетических средств.

Об авторах

Н. А. Шостак
ГОУ ВПО РГМУ Минздравсоцразвития России
Россия
Кафедра факультетской терапии им. акад. А.И. Нестерова


Н. Г. Правдюк
ГОУ ВПО РГМУ Минздравсоцразвития России
Россия
Кафедра факультетской терапии им. акад. А.И. Нестерова


Н. М. Швырева
ГОУ ВПО РГМУ Минздравсоцразвития России
Россия
Кафедра факультетской терапии им. акад. А.И. Нестерова


В. А. Егорова
ГОУ ВПО РГМУ Минздравсоцразвития России
Россия
Кафедра факультетской терапии им. акад. А.И. Нестерова


Список литературы

1. Antoniou J., Steffen T., Nelson F., et al. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest 1996;98(4):996–1003.

2. Milette P.C. The proper terminology for reporting lumbar intervertebral disk disorders. Am J Neuroradiol 1997;18:1859–66.

3. Сустав: введение в патологию и клинику заболеваний суставов. Под ред. В.Н. Павловой, Г.Г. Павлова, Н.А. Шостак, Л.И. Слуцкого. М.: Медицинское информационное агентство, 2010.

4. Marchand F., Ahmed A.M. Investigation of the laminate structure of lumbar disc anulus fibrosus. Spine 1990;15:402–10.

5. Urban J.P., Roberts S. Degeneration of the intervertebral disc. Arthritis Res Ther 2003;5:120–30.

6. Eyre D.R., Wu J.J., Fernandes R.J., et al. Recent developments in cartilage research: matrix biology of the collagen II/IX/XI heterofibril network. Biochem Soc Trans 2002;30 (Pt 6):893–9.

7. Urban J.P., Smith S., Fairbank J.C. Nutrition of the intervertebral disc. Spine 2004;29(23):2700–9.

8. Ferguson S.J., Ito K., Nolte L.P. Fluid flow and convective transport of solutes within the intervertebral disc. J Biomech 2004;37(2):213–21.

9. Le Maitre C.L., Freemont A.J., Hoyland J.A. Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. J Pathol 2004;204(1):47–54.

10. Торшин И.Ю., Громова О.А. Дисплазия соединительной ткани, магний и нуклеотидные полиморфизмы. Кардиология 2008;(9):14–8.

11. Seals D.F., Courtneidge S.A. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev 2003;17:7–30.

12. Pockert A.J, Richardson S.M., Le Maitre C.L., et al. Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration. Arthritis Rheum 2009;60(2):482–91.

13. Freemont A.J. The cellular pathobiology of the degenerate intervertebral disc and discogenic

14. back pain. Rheumatology 2009;48:5–10.

15. Boos N., Weissbach S., Rohrbach H., et al. Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine 2002;27(23):2631–44.

16. Kauppila L.I. Atherosclerosis and disc degeneration/low-back pain – a systematic review. Eur J Vasc Endovasc Surg 2009;37(6):661–70.

17. Oegema T.R. Jr., Johnson S.L., Aguiar D.J., Ogilvie J.W. Fibronectin and its fragments increase with degeneration in the human intervertebral disc. Spine 2000;25(21):2742–7.

18. Adams M.A., Roughley P.J. What is intervertebral disc degeneration, and what causes it? Spine 2006;31(18):2151–61.

19. Freemont A.J., Peacock T.E., Goupille P., et al. Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet 1997;350(9072):178–81.

20. Koshi T., Ohtori S., Inoue G., et al. Lumbar posterolateral fusion inhibits sensory nerve ingrowth into punctured lumbar intervertebral discs and upregulation of CGRP immunoreactive DRG neuron innervating punctured discs in rats. Eur Spine J 2010;19(4):593–600.

21. Johnson W.E., Caterson B., Eisenstein S.M., et al. Human intervertebral disc aggrecan

22. inhibits nerve growth in vitro. Arthritis Rheum 2002;46(10):2658–64.

23. Melrose J., Roberts S., Smith S., et al. Increased nerve and blood vessel ingrowth associated with proteoglycan depletion in an ovine anular lesion model of experimental disc degeneration. Spine 2002;27(12):1278–85.

24. Tanaka M., Nakahara S., Inoue H. A pathologic study of discs in the elderly. Separation between the cartilaginous endplate and the vertebral body. Spine 1993;18(11):1456–62.

25. Юмашев Г.С., Фурман М.Е. Остеохондрозы позвоночника. М., 1984.

26. Mok F.P., Samartzis D., Karppinen J., et al. ISSLS prize winner: prevalence, determinants, and association of Schmorl nodes of the lumbar spine with disc degeneration: a populationbased

27. study of 2449 individuals. Spine 2010;35(21):1944–52.

28. Videman T., Battié M.C., Gill K., et al. Magnetic resonance imaging findings and their relationships in the thoracic and lumbar spine: insights into the etiopathogenesis of spinal degeneration. Spine 1995;20(8):928–35.

29. Osti O.L., Vernon-Roberts B., Fraser R.D. 1990 Volvo Award in experimental studies. Anulus tears and intervertebral disc degeneration. An experimental study using an animal model. Spine 1990;15(8):762–7.

30. Rajasekaran S., Naresh-Babu J., Murugan S. Review of postcontrast MRI studies on diffusion of human lumbar discs. J Magn Reson Imaging 2007;25(2):410–8.

31. Battié M.C., Videman T., Parent E. Lumbar disc degeneration: epidemiology and genetic influences. Spine 2004;29(23):2679–90.

32. Haughton V. Medical imaging of intervertebral disc degeneration: current status of imaging. Spine 2004;29(23):2751–6.

33. Martins D.E., Oliveira V.M., Alves M.T., et al. Correlations between radiographic, magnetic resonance and histological examinations on the degeneration of human lumbar intervertebral discs. Sao Paulo Med J 2010;128(2):63–8.

34. Le Maitre C.L., Freemont A.J., Hoyland J.A. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 2005;7(4):732–45.

35. Hoyland J.A., Le Maitre C., Freemont A.J. Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc. Rheumatology 2008;47(6):809–14.

36. Zhang R., Ruan D., Zhang C. Effects of TGF-beta1 and IGF-1 on proliferation of human nucleus pulposus cells in medium with different serum concentrations. J Orthop Surg Res 2006;26:1–9.

37. Bachmeier B.E., Nerlich A., Mittermaier N., et al. Matrix metalloproteinase expression levels

38. suggest distinct enzyme roles during lumbar disc herniation and degeneration. Eur Spine J 2009;18(11):1573–86.

39. Ohtori S., Inoue G., Ito T., et al. Tumor necrosis factor-immunoreactive cells and PGP 9.5-immunoreactive nerve fibers in vertebral endplates of patients with discogenic low back pain and Modic Type 1 or Type 2 changes on MRI. Spine 2006;31(9):1026–31.

40. Power C., Frank J., Hertzman C., et al. Predictors of low back pain onset in a prospective British study. Am J Public Health 2001;91(10):1671–8.

41. Kalichman L., Hunter D.J. The genetics of intervertebral disc degeneration. Familial predisposition and heritability estimation. Joint Bone Spine 2008;75:383–7.

42. Videman T., Saarela J., Kaprio J., et al. Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing. Arthritis Rheum 2009;60(2):470–81.

43. Zhang Y., Sun Z., Liu J., Guo X. Advances in susceptibility genetics of intervertebral degenerative disc disease. Int J Biol Sci 2008;4:283–90.

44. Kalichman L., Hunter D.J. The genetics of intervertebral disc degeneration. Associated genes. Joint Bone Spine 2008;75:388–96.

45. Solovieva S., Lohiniva J., Leino-Arjas P., et al. Intervertebral disc degeneration in relation to the COL9A3 and the IL-1ss gene polymorphisms. Eur Spine J 2006;15(5):613–9.

46. Battié M.C., Videman T., Parent E. Lumbar disc degeneration: epidemiology and genetic influences. Spine 2004;29(23):2679–90.

47. Kawaguchi Y., Osada R., Kanamori M., et al. Association between an aggrecan gene polymorphism and lumbar disc degeneration Spine 1999;24(23):2456–60.

48. Solovieva S., Noponen N., Männikkö M., et al. Association between the aggrecan gene variable number of tandem repeats polymorphism and intervertebral disc degeneration. Spine 2007;32(16):1700–5.

49. Roughley P., Martens D., Rantakokko J., et al. The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage. Eur Cell Mater 2006;11:1–7.

50. Tilkeridis C., Bei T., Garantziotis S., Stratakis C.A. Association of a COL1A1 polymorphism with lumbar disc disease in young military recruits. J Med Genet 2005;42(7):44.

51. Takahashi M., Haro H., Wakabayashi Y., et al. The association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix 2001;83(4):491–5.

52. Dong D.M., Yao M., Liu B., et al. Association between the -1306C/T polymorphism of matrix metalloproteinase-2 gene and lumbar disc disease in Chinese young adults. Eur Spine J 2007;16(11):1958–61.

53. Noponen-Hietala N., Virtanen I., Karttunen R., et al. Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica. Pain 2005;114(1-2):186–94.

54. Kawaguchi Y., Kanamori M., Ishihara H., et al. The association of lumbar disc disease with

55. vitamin-D receptor gene polymorphism. J Bone Joint Surg Am 2002;84(11):2022–8.

56. Videman T., Gibbons L.E., Battié M.C., et al. The relative roles of intragenic polymorphisms of the vitamin d receptor gene in lumbar spine degeneration and bone density. Spine 2001;26(3):7–12.

57. Eser B., Cora T., Eser O., et al. Association of the polymorphisms of vitamin D receptor and

58. aggrecan genes with degenerative disc disease. Genet Test Mol Biomarkers 2010;14(3):313–7.

59. Solovieva S., Kouhia S., Leino-Arjas P., et al. Interleukin 1 polymorphisms and intervertebral disc degeneration. Epidemiology 2004;15(5):626–33.

60. Eskola P.J., Kjaer P., Daavittila I.M., et al. Genetic risk factors of disc degeneration among 12–14-year-old Danish children: a population study. Int J Mol Epidemiol Genet 2010;1(2):158–65.

61. Dai F., Belfer I., Schwartz C.E., et al. Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease. Spine

62. J 2010;10(11):949–57.

63. Fardon D.F., Milette P.C.; Combined Task Forces of the North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology. Nomenclature and classification of lumbar disc pathology. Recommendations of the Combined task Forces of the North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology. Spine

64. ;26(5):93–113.

65. Pfirrmann C.W., Metzdorf A., Zanetti M., et al. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine 2001;26(17):1873–8.

66. Modic M.T., Steinberg P.M., Ross J.S., et al. Degenerative disk disease: assessment of changes

67. in vertebral body marrow with MR imaging. Radiology 1988;166:193–9.

68. Thompson K.J., Dagher A.P., Eckel T.S., et al. Modic changes on MR images as studied with provocative diskography: clinical relevance – a retrospective study of 2457 disks. Radiology 2009;250(3):849–55.

69. Modic M.T. Modic Type 1 and Type 2 changes. J Neurosurg Spine 2007;6:150–1;discuss 151.

70. Luoma K., Vehmas T., Grönblad M., et al. Relationship of Modic type 1 change with disc degeneration: a prospective MRI study. Skeletal Radiol 2009;38(3):237–44.

71. Burke J.G., Watson R.W.G., McCormack D., et al. Intervertebral discs which cause low back

72. pain secrete high levels of proinflammatory mediators. J Bone Joint Surg Br 2002;84(2):196–201.

73. Fayad F., Lefevre-Colau M.M., Rannou F., et al. Relation of inflammatory modic changes to

74. intradiscal steroid injection outcome in chronic low back pain. Eur Spine J 2007;16(7):925–31.

75. Kuisma M., Karppinen J., Haapea M., et al. Are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same? A magnetic resonance imaging study in middle-aged male workers. BMC Musculoskelet Disord 2008;16:9–51.

76. Rahme R., Moussa R., Bou-Nassif R., et al. What happens to Modic changes following lumbar discectomy? Analysis of a cohort of 41 patients with a 3- to 5-year follow-up period. J Neurosurg Spine 2010;13(5):562–7.

77. Jensen T.S., Karppinen J., Sorensen J.S., et al. Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain. Eur Spine

78. J 2008;17(11):1407–22.

79. Last A.R., Hulbert K. Chronic low back pain: evaluation and management. Am Fam Physician 2009;79(12):1067–74.

80. Шостак Н.А., Правдюк Н.Г., Аксенова А.В., Шеметов Д.А. Возможности оптимизации анальгетической и противовоспалительной терапии у больных c острым болевым синдромом

81. в спине. Русский медицинский журнал 2006;14(8):610–4.

82. Koes B.W., van Tulder M., Chung-Wei C.L., et al. An updated overview of clinical guidelines for the management of non-specific low back pain in primary care. Eur Spine J 2010;19:2075–94.

83. Calderon L., Collin E., Velasco-Bayon D., et al. Type II collagen-hyaluronan hydrogel – a step towards a scaffold for intervertebral disc tissue engineering. Eur Cell Mater 2010;6(20):134–48.

84. da Silva M.R., Domingues C.J., Pinto R.P., et al. New perspectives on degenerative disease treatment. Acta Reumatol Port 2009;34(2):327–35.

85. Hohaus C., Ganey T.M., Minkus Y., Meisel H.J. Cell transplantation in lumbar spine disc degeneration disease. Eur Spine J 2008;17(4):492–503.


Рецензия

Для цитирования:


Шостак Н.А., Правдюк Н.Г., Швырева Н.М., Егорова В.А. БОЛЬ В СПИНЕ, АССОЦИИРОВАННАЯ С ДЕГЕНЕРАЦИЕЙ МЕЖПОЗВОНКОВОГО ДИСКА: МОРФОЛОГИЧЕСКИЕ, ГЕНЕТИЧЕСКИЕ И КЛИНИКО-ИНСТРУМЕНТАЛЬНЫЕ АСПЕКТЫ. Клиницист. 2011;5(2):13-19. https://doi.org/10.17650/1818-8338-2011-2-13-19

For citation:


Shostak N.A., Pravdyuk N.G., Shvyreva N.M., Egorova V.A. BACK PAIN ASSOCIATED WITH INTERVERTEBRAL DISK DEGENERATION: MORPHOLOGICAL, GENETIC AND CLINICO-INSTRUMENTAL ASPECTS. The Clinician. 2011;5(2):13-19. (In Russ.) https://doi.org/10.17650/1818-8338-2011-2-13-19

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