Нейродегенеративные заболевания и деменция – роль дисфункции гематоэнцефалического барьера (по материалам последних лет)
https://doi.org/10.17650/1818-8338-2025-19-1-K744
Аннотация
Представлены описание молекулярной архитектуры и физиологии гематоэнцефалического барьера (ГЭб), современные методы оценки состояния ГЭб, роль его дисфункции при некоторых нейродегенеративных заболеваниях, а также вклад сосудистой патологии. Обсуждаются патогенетические механизмы, с помощью которых нарушение ГЭб приводит к нейродегенерации. Ранняя диагностика при данных нозологиях имеет решающее значение для адекватной терапии и благоприятного прогноза. В связи с этим рассматривается возможность выявления нейровизуализационных паттернов, указывающих на нарушения проницаемости ГЭб, а также изучаются патологоанатомические характеристики дисфункции ГЭб.
Ключевые слова
гематоэнцефалический барьер,
гликокаликс,
маркер повреждения ГЭб,
дисфункция ГЭб,
нейровоспаление,
деменция
Об авторах
О. С. Левин
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России;
ГБУЗ г. Москвы «Московский многопрофильный научно-клинический центр им. С.П. Боткина» Департамента здравоохранения г. Москвы
Россия
Россия
125993 Москва, ул. Баррикадная, 2/1, стр. 1,
125284 Москва, 2й Боткинский прд, 5
З. К. Гехаева
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России
Россия
Россия
Зулихан Казбековна Гехаева
125993 Москва, ул. Баррикадная, 2/1, стр. 1
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Рецензия
Для цитирования:
Левин О.С., Гехаева З.К. Нейродегенеративные заболевания и деменция – роль дисфункции гематоэнцефалического барьера (по материалам последних лет). Клиницист. 2025;19(1):74-84. https://doi.org/10.17650/1818-8338-2025-19-1-K744
For citation:
Levin O.S., Gekhaeva Z.K. Neurodegenerative diseases and dementia: the role of blood-brain barrier dysfunction (based on recent evidence). The Clinician. 2025;19(1):74-84. (In Russ.) https://doi.org/10.17650/1818-8338-2025-19-1-K744
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