Effect of renin-angiotensin -aldosterone system blockers on myocardial remodeling processes and risk for atrial fibrillation in patients with arterial hypertension
https://doi.org/10.17650/1818-8338-2012-3-4-73-79
Abstract
The given review considers the mechanisms underlying the development and maintenance of atrial fibrillations (AF). It is noted that the processes of atrial fibrosis, ion channel remodeling, inflammation, apoptosis, impaired intercellular interactions, and myocardiocyte hypertrophy may give rise to atrial structural and functional changes in AF. The efficacy of angiotensinonverting enzyme inhibitors and angiotensin receptor antagonists is justified in patients with left ventricular systolic dysfunction.
About the Authors
O. M. Drapkina
I.M. Sechenov First Moscow State Medical University,
Ministry of Health of Russia
Russian Federation
Department of Internal Propedeutics, Faculty of Therapeutics
Russian Federation
Department of Internal Propedeutics, Faculty of Therapeutics
M. V. Kostyukevich
I.M. Sechenov First Moscow State Medical University,
Ministry of Health of Russia
Russian Federation
Department of Internal Propedeutics, Faculty of Therapeutics
Russian Federation
Department of Internal Propedeutics, Faculty of Therapeutics
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Review
For citations:
Drapkina O.M., Kostyukevich M.V. Effect of renin-angiotensin -aldosterone system blockers on myocardial remodeling processes and risk for atrial fibrillation in patients with arterial hypertension. The Clinician. 2012;6(3-4):73-79. (In Russ.) https://doi.org/10.17650/1818-8338-2012-3-4-73-79
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