24-HOUR ARTERIAL STIFFNESS PROFILE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND CHRONIC HEART FAILURE

Objective: to study the specific features of arterial stiffness (AS) in patients with chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) as evidenced by 24­hour monitoring.
Subjects and methods. A total of 111 patients with COPD, including 76 with signs of CHF, were examined. The patients with COPD and CHF were divided into 2 groups according to the presence or absence of prior myocardial infarction (MI). A BPLab МнСДП­2 apparatus was used to study 24­hour AS monitoring readings. 
Results. The patients with COPD and CHF were noted to have higher values of AS index (ASI) (during a day, daytime) and pulse wave propa­ gation velocity (during a day, daytime, nighttime) than those with COPD without CHF. There was an association between ASI and major car­ diovascular risk factors (hypertension, age, body mass index). The patients with COPD, CHF, and prior MI, unlike those without the latter, were found to have an increased augmentation index throughout the follow­up (during both daytime and nighttime). In the patients with CHF without prior MI, the diurnal ASI was considerably greater than that in both the COPD patients without CHF and those with CHF and prior MI.
Conclusion. Increased vascular wall stiffness was detected in the patients with COPD and CHF. By taking into account pronounced AS changes not only during daytime and nighttime hours, it is reasonable to perform 24­hour AS monitoring in patients with comorbidities in order to obtain more objective results. 

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