GLUCOCORTICOIDS IN THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS: POSITIVE AND NEGATIVE ASPECTS
https://doi.org/10.17650/1818-8338-2014-1-63-70
Abstract
Glucocorticoids (GCs) are first-line drugs to treat systemic lupus erythematosus (SLE) of both high and moderate activities. These are the only agents that are able to provide so prompt anti-inflammatory and immunosuppressant effects in rheumatic diseases. Along with antimalarials and immunosuppressants, GCs are used in the standard classical treatment regimen for SLE; however, despite the high efficacy of these drugs, their related immediate or delayed adverse reactions are one of the major problems in the management of a patient with SLE. Occasionally, they may be severer than the indication itself for their use and may be even fatal. The paper describes the adverse reactions observed in a female patient with SLE during long-term use of a high maintenance GC dose.
About the Authors
N. V. Seredavkina
V. A. Nasonova Research Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
A. V. Smirnov
V. A. Nasonova Research Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
I. S. Dydykina
V. A. Nasonova Research Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
T. M. Reshetnyak
V. A. Nasonova Research Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Seredavkina N.V., Smirnov A.V., Dydykina I.S., Reshetnyak T.M. GLUCOCORTICOIDS IN THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS: POSITIVE AND NEGATIVE ASPECTS. The Clinician. 2014;8(1):63-70. (In Russ.) https://doi.org/10.17650/1818-8338-2014-1-63-70
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