AUTONOMIC CARDIOVASCULAR REGULATION DISORDERS IN PATIENTS WITH PSORIATIC ARTHRITIS
https://doi.org/10.17650/1818-8338-2011-2-57-61
Abstract
Aim – to identify disorders of autonomic regulation of cardiac activity in patients with psoriatic arthritis (PsA) by determining the heart rate variability (HRV), and also establish the relationship of HRV with systemic inflammation and traditional cardiovascular risk factors.
Materials and methods. The study included 53 patients with PsA (mean age 43.64 ± 12.1 years), including 48.2 % men, mean disease duration
was 10.32 ± 10.2 years. The control group included 25 healthy volunteers (average age 46.7 ± 12.45 years, 49.1 % – men). Time and
frequency measures of HRV were analyzed. Active PsA was determined by an index DAS4, rate erythrocyte sedimentation rate (ESR), levels of C-reactive protein (CRP) and fibrinogen. Patients with clinical manifestations of cardiovascular disease, and patients with symptoms
of carotid atherosclerosis, detected by duplex study were excluded.
Results. Deterioration of HRV in patients with PsA compared with those in patients of the control group, the availability of statistically significant reverse relationship of temporal and spectral parameters of HRV with PsA activity (ESR, CRP, entezit score, DAS4), duration of arthritis, the classical factors of cardiovascular risk were established.
Conclusion. Patients with PsA had noted a violation of autonomic regulation of cardiac activity in the form of reduced HRV and activation of the sympathetic part of it. Identified changes were associated with activity of systemic inflammation and classical factors of cardiovascular risk.
About the Authors
A. P. Rebrov
Razumovsky Saratov State Medical University, Ministry of Health and Social Development of Russia
Russian Federation
Russian Federation
D. A. Poddubnyy
Razumovsky Saratov State Medical University, Ministry of Health and Social Development of Russia
Russian Federation
Russian Federation
I. Z. Gaydukova
Regional Hospital
Russian Federation
Russian Federation
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Review
For citations:
Rebrov A.P., Poddubnyy D.A., Gaydukova I.Z. AUTONOMIC CARDIOVASCULAR REGULATION DISORDERS IN PATIENTS WITH PSORIATIC ARTHRITIS. The Clinician. 2011;5(2):57-61. (In Russ.) https://doi.org/10.17650/1818-8338-2011-2-57-61
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