RECURRENT ORAL AND OROPHARYNGEAL CANCER: CLINICAL PICTURE, DIAGNOSIS, AND TREATMENT
https://doi.org/10.17650/1818-8338-2013-1-48-54
Abstract
Malignant oral tumors account for 6 % in the total cancer incidence. The rate of recurrent tumors ranges from 25 to 50 %. About 80 % of patients with failed treatment are to undergo radiation, chemoradiation, or drug therapy. After retreatment, severe complications occur in more than half of the patients even to death (2 %). Some progress has been made in the treatment of recurrent tumors due to the current possibilities of surgical treatment. Surgical reintervention can be made and satisfactory treatment results obtained in a number of patients even if they develop recurrent tumor after a previous saving operation.
About the Authors
I. A. ZaderenkoRussian Federation
Department of Oral Surgery and Surgical Dentistry
S. B. Aliyeva
Russian Federation
A. Yu. Drobyshev
Russian Federation
Department of Oral Surgery and Surgical Dentistry
R. I. Azizyan
Russian Federation
References
1. Пачес А.И. Опухоли головы и шеи. М.: Медицина, 2000.
2. Матякин Е.Г., Уваров А.А., Матяки н Г.Г., Парамонов В.А. Особенности хирургических вмешательств у больных раком полости рта и ротоглотки после радикального курса лучевой терапии. Мед радиол 1991;36(4):33–6.
3. Кропотов М.А., Соболевский В.А., Азизян Р.И. и др. Органосохраняющие и реконструктивные операции на нижней челюсти в комбинированном лечении рака слизистой оболочки полости
4. рта: Учебное пособие. М., 2007. С. 4–15.
5. Adelstein D.J., Lavertu P., Saxton J.P. et al. Mature results of a phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy along in respectable stage III and IV
6. squamous cell carcinoma of the head and neck. Сancer 2000;88(4):876–83.
7. Fu K.K., Pojak T.F., Trotti A. et al. A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. Int J Radiat Oncol Biol Phys 2000;48(1):7–16.
8. Kagawa K., Yamaguchi H., Kizaki H. et al. Clinical significance of salvage surgery for recurrent pharyngeal or oral cancer after definitive radiation therapy. J Clin Oncol 2010;28(15 Suppl):e16018.
9. Adelstein D.J. Squamous cell head and neck cancer. Humana Press Int., 2005.
10. Goodwin W.J.Jr. Salvage surgery for patients with recurrent squamous cell carcinoma of the upper aerodigestive tract: when do the ends justify the means? Laryngoscope 2000;110(3 Pt 2 Suppl 93):1–18.
11. Abgral R., Querellou S., Potard G. et al. Does 18F-FDG PET/CT improve the detection of posttreatment recurrence of head and neck squamous cell carcinoma in patients negative for disease on clinical follow-up? J Nucl Med 2009;50(1):24–9.
12. Lee J.K., Tyan Y.S., Huang W.S. Comparison of thallium-201 SPET and CT/MRI in the detection of residual/recurrent squamous cell carcinoma of the oral cavity. Eur J Nucl Med Mol Imaging
13. ;31(4):528–31.
14. Agra I.M., Carvalho A.L., Pinto C.A. et al. Biological markers and prognosis in recurrent cancer after salvage surgery. Arch Otolaryngol Head Neck Surg 2008;134(7):743–9.
15. Vermorken J.B. Medical treatment in head and neck cancer. Ann Oncol 2005;16(Suppl 2):ii258–ii264.
16. Ng S.H., Yen T.C., Chang J.T. et al. Prospective study of [18F]fluorodeoxyglucose positron emission tomography and computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with palpably negative neck. J Clin Oncol 2006;24(27):4371–6.
17. Lindberg R.D., Fletcher G.H. The role of irradiation in the management of head and neck cancer: analysis of results and causes of failure. Tumori 1978;64(3):313–25.
18. Stevens K.R.Jr, Britsch A., Moss W.T. High-dose reirradiation of head neck cancer with curative intent. Int J Radiat Oncol Biol Phys 1994;29(4):687–98.
19. Wang C.C. To reirradiate or not to reirradiate? Int J Radiat Oncol Biol Phys 1994;29(4):913.
20. Tanvetyanon T., Padhya T., McCaffrey J. et al. Prognostic factors for survival after salvage reirradiation of head and neck cancer. J Clin Oncol 2009;27(12):1983–91.
21. Vermorken J.B., Specenier P. Optimal treatment for recurrent/metastatic head and neck cancer. Ann Oncol 2010;21(Suppl 7):vii252–vii261.
22. Choe K.S, Haraf D.J., Solanki A. et al. Prior chemoradiotherapy adversely impacts outcomes of recurrent and second primary head and neck cancer treated with concurrent chemotherapy and reirradiation. Cancer 2011;117(20):4671–8.
23. Arrannd J.P., Cvitkovic E., Recondo G. et al. Salvage chemotherapy in recurrent head neck cancer: the Institute Gustav Roués’ experience. Am J Otolaryngology 1993;14(5):301–6.
24. Forastiere A., Koch W., Trotti A., Sidransky D. Head and neck cancer. N Engl J Med 2001;345(26):1890–900.
25. Lee S.C., Shores C.G., Weissler M.C. Salvage surgery after failed primary concomitant chemoradiation. Curr Opin Otolaryngol Head Neck Surg 2008;16(2):135–40.
26. Koo B.S, Lim Y.C., Lee J.S., Choi E.C. Recurrence and salvage treatment of squamous cell carcinoma of the oral cavity. Oral Oncol 2006;42(8):789–94.
27. Gilbert H., Kagan A.R. Recurrence patterns in squamous cell carcinoma of the oral cavity, pharynx, and larynx. J Surg Oncol 1974;6(5):357–80.
28. Agra I.M., Carvalho A.L., Ulbrich F.S. et al. Prognostic factors in salvage surgery for recurrent oral and oropharyngeal cancer. Head Neck 2006;28(2):107–13.
29. Kostrzewa J.P., Lancaster W.P., Iseli T.A. et al. Оutcomes of salvage surgery with free flap reconstruction for recurrent oral and oropharyngeal cancer. Laryngoscope 2010;120(2):267–72.
30. Magrin J., Kowalski L.P., Sabóia M., Sabóia R.P. Major glossectomy: end results of 106 cases. Eur J Cancer B Oral Oncol 1996;32B(6):407–12.
31. Yuen A.P., Wei W.I., Wong S.H., Ng R.W. Local recurrence of carcinoma of the tongue after glossectomy: patient prognosis. Ear Nose Throat J 1998;77(3):181–4.
32. Agra I.M., Filho J.G., Martins E.P., Kowalski L.P. Second salvage surgery for rerecurrent oral cavity and oropharynx carcinoma. Head Neck 2010;32(8):997–1002.
33. Федотенко С.П., Жарков О.А. Послеоперационные осложнения и выживаемость у больных раком полости рта и ротоглотк и, оперированных по поводу остаточной опухоли или рецидива после лучевой терапии. Опухоли головы и шеи 2011;(1):31–7.
34. Liu S.A., Wong Y.K., Lin J.C. et al. Impact of recurrence interval on survival of oral cavity squamous cell carcinoma patients after local relapse. Otolaryngol Head Neck Surg 2007;136(1):112–8.
35. Mücke T., Wagenpfeil S., Kesting M.R. et al. Recurrence interval affects survival after local relapse of oral cancer. Oral Oncol 2009;45(8):687–91.
36. Nguyen T.V., Yueh B. Weight loss predicts mortality after recurrent oral cavity and oropharyngeal carcinomas. Cancer 2002;95(3):553–62.
37. Davidson J., Keane T., Brown D. et al. Surgical salvage after radiotherapy for advanced laryngopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 1997;123(4):420–4.
38. Patel R.S., Clark J.R., Dirven R. et al. Prognostic factors in the surgical treatment of patients with oral carcinoma. ANZ J Surg 2009;79(1–2):19–22.
39. Girod D.A., McCulloch T.M., Tsue T.T., Weymuller E.A. Jr. Risk factors for complications in cleanontaminated head and neck surgical procedures. Head Neck 1995;17(1):7–13.
40. Sassler A.M., Esclamado R.M., Wolf G.T. Surgery after organ-preservation: analysis of wound complications. Arch Otolaryngol Head Neck Surg 1995;121(2):162–5.
Review
For citations:
Zaderenko I.A., Aliyeva S.B., Drobyshev A.Yu., Azizyan R.I. RECURRENT ORAL AND OROPHARYNGEAL CANCER: CLINICAL PICTURE, DIAGNOSIS, AND TREATMENT. The Clinician. 2013;7(1):48-54. (In Russ.) https://doi.org/10.17650/1818-8338-2013-1-48-54