PREDICTORS OF CHRONIC KIDNEY DISEASE DEVELOPMENT IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
https://doi.org/10.17650/1818-8338-2016-10-3-51-57
Abstract
Оbjective: to identify predictors of reduction of glomerular filtration in patients with chronic obstructive pulmonary disease (COPD).
Materials and methods. Maps analyzed 145 patients with a diagnosis of COPD. The majority (84.1 %, n = 122) were male (the average age of men 60.7 ± 0.9 years, average age of women 62.0 ± 2.7 years). A comparative analysis of the prevalence of risk factors for chronic kidney diseace (CKD) in patients with COPD by age, sex, smoking, hypertension, overweight and others. Calculated glomerular filtration rate (GFR) by using the equation Chronic Kidney Disease Epidemiology Collaboration (CKD–EPI), according to which the patients were divided into 6 groups: group 1 – hyperfiltration, group 2 – GFRCKD–EPI ≥ 90 ml/min/1.73 m2 , group 3 – GFRCKD–EPI 60–89 ml/min/1.73 m2 , group 4 – GFRCKD–EPI 45–59 ml/min/1,73 m2 , group 5 – GFRCKD–EPI 30–44 ml/min/1,73 m2 and group 6 – GFRCKD–EPI < 30 ml/min/1.73 m2 .
Results. In COPD patients there is a high frequency of risk factors for CKD. The correlation between the prevalence of risk factors for CKD and the severity of COPD. The main predictors of CKD in patients with COPD: COPD experience more than 9.0 years, body mass index more than 26.5 kg/m2 , smoker index more of 51.3, albumin 44.0 g/l, total protein of more than 70.0 g/l, forced expiratory volume in the first second of less than 1.6 l, right atrium more than 35.5 mm, systolic pulmonary artery pressure more than 36.6 mm Hg, the thickness of the posterior wall of the left ventricle more than 10.5 mm, the Tiffeneau index less than 62.0 %.
Conclusion. It is established that in COPD patients there is a high frequency of both traditional and additional risk factors for reduced GFR.
About the Author
D. A. Dolgopolova
Surgut State University, Medical Institute;
Surgut District Clinical Hospital
Russian Federation
Russian Federation
Department of hospital therapy, 1 Prospect Lenina, Surgut 628412;
14 Energetikov St., Surgut 628408
References
1. Чучалин А.Г., Цеймах И.Я., Момот А.П. и др. Изменения системных воспалительных и гемостатических реакций у больных с обострением хронической обструктивной болезни легких с сопутствующими хронической сердечной недостаточностью и ожирением. Пульмонология 2014;(6):25–32. [Chuchalin A.G., Tseymakh I.Ya., Momot A.P. et al. Changes in systemic inflammatory and hemostatic responses in patients with exacerbation of chronic obstructive pulmonary disease with concomitant chronic heart failure and obesity. Рul’monologiya = Pulmonology 2014;(6):25–32. (In Russ.)].
2. Задионченко В.С., Адашева Т.В., Ли В.В. и др. Артериальная гипертензия и хроническая обструктивная болезнь легких – проблемы выбора терапии. Лечащий врач 2012;(7):77–81. [Zadionchenko V.C., Adasheva T.V., Lee V.V. et al. Arterial hypertension and chronic obstructive pulmonary disease – problems in the choice of therapy. Lechashchiy vrach = Doctor 2012;(7):77–81. (In Russ.)].
3. Лазебник Л.Б., Конев Ю.В., Ефремов Л.И. Полиморбидность в гериатрической практике: количественная и качественная оценка. Клиническая геронтология 2012;18(1–2):36–42. [Lazebnik L.B., Konev V.Yu., Еfremov L.I. Polymorbidity in geriatric practice: quantitative and qualitative evaluation. Klinicheskaya gerontologiya = Clinical Gerontology 2012;18(1–2):36–42. (In Russ.)].
4. Дворецкий Л.И., Чистякова Е.М. Остеопороз у больных ХОБЛ: коморбидность или системное проявление? Consilium medicum 2007;9(12):42–8. [Dvoretskiy L.I., Chistyakova E.M. Osteoporosis in patients with COPD: comorbidity or systemic manifestation? Consilium medicum 2007;9(12):42–8. (In Russ.)].
5. Белялов Ф.И. Двенадцать тезисов коморбидности. Клиническая медицина 2009;87(12):69–71. [Belyalov F.I. Twelve theses of comorbidity. Klinicheskaya meditsina = Clinical Medicine 2009;87(12):69–71. (In Russ.)].
6. Насонов Е.Л., Гордеев А.В., Галушко Е.А. Ревматические заболевания и мультиморбидность. Терапевтический архив 2015;87(5):4–9. [Nasonov E.A., Gordeev A.V., Galushko E.A. Rheumatic diseases and multimorbidity. Terapevticheskiy arkhiv = Therapeutic Archive 2015;87(5): 4–9. (InRuss.)].
7. Скотников А.С., Дохова О.М., Шульгина Е.С. Место ХОБЛ в развитии и прогрессировании коморбидности. Лечащий врач 2015;(10):16. [Skotnikov A.S., Dokhova O.M., Shul’gina E.S. Place COPD in the development and progression of comorbidity. Lechashchiy vrach = Doctor 2015;(10):16. (In Russ.)].
8. Смирнов А.В., Шилов Е.М., Добронравов В.А. и др. Национальные рекомендации. Хроническая болезнь почек: основные принципы скрининга, диагностики, профилактики и подходы к лечению. Нефрология 2012;16(1):85–115. [SmirnovA. V., ShilovE. M., Dobronravov V.A. et al. The national recommendations. Chronic kidney disease: basic principles of screening, diagnosis, prevention and treatment approaches. Nefrologiya = Nephrology 2012;16(1):85–115. (In Russ.)].
9. Moe Sh.M., Roudebush V.A., Drüeke T.B. Клинические практические рекомендации по диагностике, оценке, профилактике и лечению минеральных и костных нарушений при хронической болезни почек (МКН-ХБП). (Краткое изложение KDIGO). Нефрология и диализ 2011; 13(1):8–12. [Moe Sh.M., Roudebush V.A., Drüeke T.B. Clinical practice guidelines for the diagnosis, evaluation, prevention and treatment of mineral and bone disorders in chronic kidney disease (MKN-CKD). A brief statement by KDIGO. Nefrologiya i dializ = Nephrology and Dialysis 2011;13(1):8–12. (InRuss.)].
10. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2013. Available at: http://www.goldcopd.org/.
11. Couser W.G., Remuzzi G., Mendis S. et al. The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int 2011; 80(12):1258–70. DOI: 10.1038/ki.2011.368.
12. Drüeke T.B., Parfrey P.S. Summary of the KDIGO guideline on anemia and comment: reading between the (guide) line(s). Kidney Int 2012;82(9):952–60. DOI: 10.1038/ki.2012.270.
13. Болотова Е.В., Дудникова А.В. Особенности дисфункции почек у пациентов с хронической обструктивной болезнью легких. Клиническая нефрология 2015;(2–3): 27–32. [Bolotova E.V., Dudnikova A.V. Peculiarities of renal dysfunction in patients with chronic obstructive pulmonary disease. Klinicheskaya nefrologiya = Clinical Nephrology 2015;(2–3):27–32. (In Russ.)].
14. Vestbo J., Hurd S.S., Agustí A.G. et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013;187(4):347–65.
15. Валентей Д.И. Демографический энциклопедический словарь. М.: Советская энциклопедия, 1985. [Demographic encyclopedic dictionary. Valentey D.I. Moscow: Sovetskaya entsiklopediya, 1985. (In Russ.)].
16. Оленко Е.С. Кодочигова А.И., Киричук В.Ф. и др. Факторы риска развития хронической болезни почек. Вестник Тамбовского университета. Серия: Естественные и технические науки 2012;17(4):1293–9. [Olenko E.S., Kodochigova A.I., Kirichuk V.F. et al. Risk factors for development of chronic kidney disease. Vestnik Tambovskogo universiteta = Bulletin of the Tambov University. Series: Natural and Technical Sciences 2012;17(4):1293–9. (In Russ.)].
17. Levey A.S., Stevens LA., Schmid C.H. et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009;150(9):604–12.
18. Федеральные клинические рекомендации по диагностике и лечению ХОБЛ. Российское респираторное общество, 2013. Доступно по: http://www.pulmonology.ru/download/COPD20142.doc. [Federal clinical recommendations on diagnostics and treatment of COPD. Russian respiratory society, 2013. Available at: http://www.pulmonology.ru/download/COPD20142.doc. (In Russ.)].
19. Чазова И.Е., Чучалин А.Г., Зыков К.A., Ратова Л.Г. Диагностика и лечение пациентов с артериальной гипертонией и хронической обструктивной болезнью легких. Рекомендации Российского медицинского общества по артериальной гипертонии и Российского респираторного общества. Системные гипертензии 2013;10(1):5–35. [Chazova I.E., Chuchalin A.G., Zykov K.A., Ratova L.G. Diagnosis and treatment of patients with arterial hypertension and chronic obstructive pulmonary disease. Recommendations of Russian Medical Society on Arterial Hypertension and Russian Respiratory Society. Sistemnye gipertenzii = Systemic Hypertension 2013;10(1):5–35. (In Russ.)]. Украинцев С.Е., Брежнева Т.Ю. Кахексия при хронической обструктивной болезни легких: диагностика и лечение. Пульмонология 2012;(3):104–8. [Ukraintsev S.E., Brezhnevа T.Yu. Cachexia in chronic obstructive pulmonary disease: diagnosis and treatment. Рul’monologiya = Pulmonology 2012;(3):104–8. (In Russ.)]. DOI: 10.18093/0869-0189-2012-0-3-104-108.
20. Man W.D., Kemp P., Moxham J., Polkey M.I. Skeletal muscle dysfunction in COPD: clinical and laboratory observations. Clin Sci (Lond) 2010;117(7):251–64. DOI: 10.1042/CS20080659.
21. Qaseem A., Wilt T.J., Weinberger S.E. et al. Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society. Ann Intern Med 2011;155(3):179–91. DOI: 10.7326/0003-4819-155-3-201108020-00008.
22. Мухин Н.А., Моисеев В.С., Кобалава Ж.Д. и др. Кардиоренальные взаимодействия: клиническое значение и роль в патогенезе заболеваний сердечно-сосудистой системы и почек. Терапевтический архив 2004;76(6):39–46. [Mukhin N.A. Moiseev V.S., Kobalava Zh.D. et al. Cardiorenal interactions: clinical significance and role in the pathogenesis of diseases of the cardiovascular system and kidneys. Тerapevticheskiy arkhiv = TherapeuticArchive 2004;76(6):39–46. (In Russ.)].
Review
For citations:
Dolgopolova D.A. PREDICTORS OF CHRONIC KIDNEY DISEASE DEVELOPMENT IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE. The Clinician. 2016;10(3):51-57. (In Russ.) https://doi.org/10.17650/1818-8338-2016-10-3-51-57
Views:
1486
Email this article 