A COMPREHENSIVE ANALYSIS DIABETES OF RISK FACTORS IN PATIENTS WITH CHRONIC PANCREATITIS
https://doi.org/10.17650/1818-8338-2012-6-2-23-26
Abstract
Aim – to perform comprehensive analysis of the risk factors of diabetes mellitus (DM) in patients with chronic pancreatitis (CP). Materials and methods. All examined patients with chronic pancreatitis (CP) were divided into 2 groups. The first group – 38 patients with the progression of the diabetes in the first 3 years of the CP, the second – 44 people with no diabetes after 10 years of disease. Formation of CP etiologic groups based on the mandatory presence of one of two factors: alcohol abuse, the presence of disease of biliary system. The combination of two etiological factors wasl exclusion criteria. Results and conclusion. Among the examined patients biliary form of CP occurred in 52 patients, alcohol – in 30 patients. It was found that in the first three years of CP risk of diabetes is not associated with family history, obesity, number of exacerbations, but in the form of alcoholic CP DM formed almost two times more often than in the biliary. When combined with CP in patients with diabetes were significantly more common strain of the main flow and structural changes in the tail of the pancreas.
About the Authors
M. A. KunitsynaRussian Federation
M. V. Shestakova
Russian Federation
References
1. Винокурова Л.В., Астафьева О.В. Взаимосвязь экзокринной и эндокринной функций поджелудочной железы при хроническом алкогольном панкреатите. Экспер. и клин. гастроэнтерол 2002;(4):58–61.
2. Дробижев М.Ю., Суркова Е.В., Мельникова О.Г. Эпидемиология сахарного диабета у больных, наблюдающихся терапевтами, кардиологами, неврологами. Consilium medicum 2008;10(12):92–6.
3. Malka D., Hammel P. Can the natural history of diabetes be changed in chronic pancreatitis? Gastroenterol Clin Biol 2003;27:45–50.
4. Ewald N., Kaufmann C., Raspe A. et al. Prevalence of diabetes mellitus secondary to pancreatic diseases (type 3c). Pancreatology 2006;6:394.
5. Rothenbacher D., Löw M., Hardt P.D. et al. Prevalence and determinants of exocrine pancreatic insufficiency among older adults: Results of a population-based study. Scand J Gastroenterol 2005;40:697–704.
6. Комаров Ф.И., Гидаятов А.А. Поджелудочная железа как эндокринный орган (об-зор литературы). Мед РЖ 1987;(1):24–38.
7. Губергриц Н.Б., Лукашевич Г.М., Голубова О.А. и др. Панкреатогeнный сахарный диабет. Рос. журн. гастроэнтерол, гепатол. и колопроктол. 2007;(6):12–6.
8. Cui Y.F., Andersen D.K. Pancreatogenic diabetes: Special considerations for management. Pancreatology 2011;11:279–94.
9. Onodera M., Okazaki K., Morita M. et al. Immune complex specific for the pancreatic duct antigen in patients with idiopathic chronic pancreatitis and Sjogren syndrome. Autoimmunity 1994;19:23–9.
10. Kloppel G, Solcia E, Longnecker D. et al. Histological typing of tumors of the exocrine pancreas. WHO International Histological Classification of Tumors. Second edition. Berlin, Heidelberg, New York: WHO; 1996.
Review
For citations:
Kunitsyna M.A., Shestakova M.V. A COMPREHENSIVE ANALYSIS DIABETES OF RISK FACTORS IN PATIENTS WITH CHRONIC PANCREATITIS. The Clinician. 2012;6(2):23-26. (In Russ.) https://doi.org/10.17650/1818-8338-2012-6-2-23-26