РОЛЬ ЦИТОКИНОВОЙ СИСТЕМЫ RANKL-RANK-OPG И КАТЕПСИНА К В ПАТОГЕНЕЗЕ ОСТЕОПОРОЗА: ДОСТИЖЕНИЯ И ПЕРСПЕКТИВЫ В ЛЕЧЕНИИ ЗАБОЛЕВАНИЯ
https://doi.org/10.17650/1818-8338-2012-6-2-9-16
Аннотация
В обзоре литературы представлены современные взгляды на клеточно-молекулярные механизмы развития ремоделирования кости и патогенез остеопороза. Открытие цитокиновой системы RANKL-RANK-OPG и значительной роли катепсина К в процессе ремоделирования костной ткани внесло значительный прогресс в понимание механизмов развития остеопороза и позволило разработать препараты нового поколения – деносумаб, полностью человеческое моноклональное антитело к RANKL (receptor activator nucleus factor kappa B ligand), и ингибитор катепсина К оданакатиб, угнетающие процесс резорбции костной ткани.
Ключевые слова
Об авторах
С. Сагаловски
Клиника Медиан, Бад Лаузик, Германия
Германия
Отделение ортопедии
Германия
Отделение ортопедии
П. Кунце
Клиника Медиан, Бад Лаузик, Германия
Германия
Отделение ортопедии
Германия
Отделение ортопедии
М. Шенерт
Клиника Медиан, Бад Лаузик, Германия
Германия
Отделение ортопедии
Германия
Отделение ортопедии
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Рецензия
Для цитирования:
Сагаловски С., Кунце П., Шенерт М. РОЛЬ ЦИТОКИНОВОЙ СИСТЕМЫ RANKL-RANK-OPG И КАТЕПСИНА К В ПАТОГЕНЕЗЕ ОСТЕОПОРОЗА: ДОСТИЖЕНИЯ И ПЕРСПЕКТИВЫ В ЛЕЧЕНИИ ЗАБОЛЕВАНИЯ. Клиницист. 2012;6(2):9-16. https://doi.org/10.17650/1818-8338-2012-6-2-9-16
For citation:
Sagalovsky S., Kunze P., Schönert M. THE ROLE OF CYTOKINE SYSTEM RANKL-RANK-OPG AND CATHEPSIN K IN THE PATHOGENESIS OF OSTEOPOROSIS: ACHIEVEMENTS AND PERSPECTIVES IN THE TREATMENT OF DISEASE. The Clinician. 2012;6(2):9-16. (In Russ.) https://doi.org/10.17650/1818-8338-2012-6-2-9-16
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