<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">The Clinician</journal-id><journal-title-group><journal-title xml:lang="en">The Clinician</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиницист</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8338</issn><issn publication-format="electronic">2412-8775</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">78</article-id><article-id pub-id-type="doi">10.17650/1818-8338-2011-4-10-16</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">MIGRAINE: BASIC PRINCIPLES OF TREATMENT AND PREVENTION</article-title><trans-title-group xml:lang="ru"><trans-title>МИГРЕНЬ: ОСНОВНЫЕ ПРИНЦИПЫ ЛЕЧЕНИЯ И ПРОФИЛАКТИКИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Esin</surname><given-names>O. R.</given-names></name><name xml:lang="ru"><surname>Есин</surname><given-names>О. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Naprienko</surname><given-names>M. V.</given-names></name><name xml:lang="ru"><surname>Наприенко</surname><given-names>М. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Esin</surname><given-names>R. G.</given-names></name><name xml:lang="ru"><surname>Есин</surname><given-names>Р. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>radyesin@gmail.com</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kazan State Medical Academy</institution></aff><aff><institution xml:lang="ru">ГОУ ДПО Казанская государственная медицинская академия</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University</institution></aff><aff><institution xml:lang="ru">ГОУ ВПО 1-й МГМУ им. И.М. Сеченова</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ГОУ ДПО Казанская государственная медицинская академия</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2011</year></pub-date><volume>5</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>10</fpage><lpage>16</lpage><history><date date-type="received" iso-8601-date="2014-07-16"><day>16</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-16"><day>16</day><month>07</month><year>2014</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2011, Esin O.R., Naprienko M.V., Esin R.G.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2011, Есин О.Р., Наприенко М.В., Есин Р.Г.</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="en">Esin O.R., Naprienko M.V., Esin R.G.</copyright-holder><copyright-holder xml:lang="ru">Есин О.Р., Наприенко М.В., Есин Р.Г.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://klinitsist.abvpress.ru/Klin/article/view/78">https://klinitsist.abvpress.ru/Klin/article/view/78</self-uri><abstract xml:lang="en"><p>Modern recommendations for the migraine attack treatment and it's prophylaxis are analyzed in this review. Established, that acetylsalicylic acid, diclofenac potassium, ibuprofen, naproxen, paracetamol, metamizol and their combination with caffeine are drugs of the first choice for migraine attack treatment. Metoclopramide and domperidone are used to reduce nausea and vomiting. Also triptans are high effective drugs for migraine attack treatment. Metoprolol, propranolol, flunarizine, valproic acid can be used for migraine prophylaxis. Drugs of the second choice are: amitriptyline, venlafaxine, naproxen and bisoprolol.</p></abstract><trans-abstract xml:lang="ru"><p>В обзоре проанализированы современные рекомендации по лечению мигренозной атаки и профилактике мигрени. Установлено, что для лечения мигренозной атаки доказанной эффективностью обладают ацетилсалициловая кислота, диклофенак натрия, ибупрофен, напроксен, парацетамол, метамизол и их комбинации с кофеином. Для уменьшения тошноты и рвоты рекомендуются метоклопрамид и домперидон. Высокой эффективностью лечения мигренозной атаки обладают триптаны. Для профилактики мигрени применяют метопролол, пропранолол, флунаризин, препараты вальпроевой кислоты. Препаратами 2-й линии для профилактики мигрени являются амитриптилин, венлафаксин, напроксен, бисопролол.</p></trans-abstract><kwd-group xml:lang="en"><kwd>migraine</kwd><kwd>aura</kwd><kwd>treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>мигрень</kwd><kwd>аура</kwd><kwd>лечение</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd ed. Cephalalgia 2004; 24 (Suppl 1):9–160.</mixed-citation><mixed-citation xml:lang="ru">Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd ed. Cephalalgia 2004; 24 (Suppl 1):9–160.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Табеева Г.Р., Азимова Ю.Э. Профи лактическое лечение мигрени. Практическое руководство для врачей. М.: IF-пресс, 2009.</mixed-citation><mixed-citation xml:lang="ru">Табеева Г.Р., Азимова Ю.Э. Профи лактическое лечение мигрени. Практическое руководство для врачей. М.: IF-пресс, 2009.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. DeVries J.M., Spierings E.L.H. Migraine. In: N.R. Mehta, G.E. Maloney, D.S. Bana, S.J. Scrivani, eds. Head, face, and neck pain: science, evaluation, and management. An interdisciplinary approach. Weinheim: John Wiley &amp; Sons, 2009; p. 108–30.</mixed-citation><mixed-citation xml:lang="ru">DeVries J.M., Spierings E.L.H. Migraine. In: N.R. Mehta, G.E. Maloney, D.S. Bana, S.J. Scrivani, eds. Head, face, and neck pain: science, evaluation, and management. An interdisciplinary approach. Weinheim: John Wiley &amp; Sons, 2009; p. 108–30.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Lipton R.B., Stewart W.F., Diamond S., et al. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 2001;41(7):646–57.</mixed-citation><mixed-citation xml:lang="ru">Lipton R.B., Stewart W.F., Diamond S., et al. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 2001;41(7):646–57.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Leonardi M., Steiner T.J., Scher A.T., Lipton R.B. The global burden of migraine: measuring disability in headache disorders with WHO; Classification of Functioning Disability and health (ICF). J Headache Pain 2005; 6:429–40.</mixed-citation><mixed-citation xml:lang="ru">Leonardi M., Steiner T.J., Scher A.T., Lipton R.B. The global burden of migraine: measuring disability in headache disorders with WHO; Classification of Functioning Disability and health (ICF). J Headache Pain 2005; 6:429–40.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Осипова В.В. Качество жизни при мигрени: роль коморбидных нарушений. http://headache-society.ru/publikatsii/kachestvo-zhizni-pri-migreni-rolkomorbidnyih-narusheniy.html</mixed-citation><mixed-citation xml:lang="ru">Осипова В.В. Качество жизни при мигрени: роль коморбидных нарушений. http://headache-society.ru/publikatsii/kachestvo-zhizni-pri-migreni-rolkomorbidnyih-narusheniy.html</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Silberstein S., Tepper S., Brandes J., et al. Randomised placebo-controlled trial of rofecoxib in the acute treatment of migraine. Neurology 2004;62:1552–7.</mixed-citation><mixed-citation xml:lang="ru">Silberstein S., Tepper S., Brandes J., et al. Randomised placebo-controlled trial of rofecoxib in the acute treatment of migraine. Neurology 2004;62:1552–7.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Tfelt-Hansen P., Block G., Dahlof C., et al. Guidelines for controlled trials of drugs in migraine: second edition. Cephalalgia 2000;20:765–86.</mixed-citation><mixed-citation xml:lang="ru">Tfelt-Hansen P., Block G., Dahlof C., et al. Guidelines for controlled trials of drugs in migraine: second edition. Cephalalgia 2000;20:765–86.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Diener H.C., Bussone G., de Liano H., et al. Placebo-controlled comparison of effervescent acetylsalicylic acid, sumatriptan and ibuprofen in the treatment of migraine attacks. Cephalalgia 2004;24:947–54.</mixed-citation><mixed-citation xml:lang="ru">Diener H.C., Bussone G., de Liano H., et al. Placebo-controlled comparison of effervescent acetylsalicylic acid, sumatriptan and ibuprofen in the treatment of migraine attacks. Cephalalgia 2004;24:947–54.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Kloster R., Nestvold K., Vilming S.T. A double-blind study of ibuprofen versus placebo in the treatment of acute migraine attacks. Cephalalgia 1992;12:169–71.</mixed-citation><mixed-citation xml:lang="ru">Kloster R., Nestvold K., Vilming S.T. A double-blind study of ibuprofen versus placebo in the treatment of acute migraine attacks. Cephalalgia 1992;12:169–71.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Gobel H., Heinze A., Niederberger U., et al. Efficacy of phenazone in the treatment of acute</mixed-citation><mixed-citation xml:lang="ru">Gobel H., Heinze A., Niederberger U., et al. Efficacy of phenazone in the treatment of acute</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><mixed-citation>migraine attacks: a double-blind, placebocontrolled, randomized study. Cephalalgia 2004; 24:888–93.</mixed-citation></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">12. Tulunay F.C., Ergun H., Gulmez S.E., et al. The efficacy and safety of dipyrone (Novalgin) tablets in the treatment of acute migraine attacks: a double-blind, crossover, randomized, placebo-controlled, multi-center study. Funct Neurol 2004;19:197–202.</mixed-citation><mixed-citation xml:lang="ru">Tulunay F.C., Ergun H., Gulmez S.E., et al. The efficacy and safety of dipyrone (Novalgin) tablets in the treatment of acute migraine attacks: a double-blind, crossover, randomized, placebo-controlled, multi-center study. Funct Neurol 2004;19:197–202.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">13. Lipton R.B., Baggish J.S., Stewart W.F., et al. Efficacy and safety of acetaminophen in the treatment of migraine: results of a randomized, double-blind, placebo-controlled, populationbased</mixed-citation><mixed-citation xml:lang="ru">Lipton R.B., Baggish J.S., Stewart W.F., et al. Efficacy and safety of acetaminophen in the treatment of migraine: results of a randomized, double-blind, placebo-controlled, populationbased</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><mixed-citation>study. Arch Intern Med 2000; 160:3486–92.</mixed-citation></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">14. Diener H., Pfaffenrath V., Pageler L. The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multi-centre, randomized, double-blind, single-dose, placebo-controlled parallel group study. Cephalalgia 2005;25:776–87.</mixed-citation><mixed-citation xml:lang="ru">Diener H., Pfaffenrath V., Pageler L. The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multi-centre, randomized, double-blind, single-dose, placebo-controlled parallel group study. Cephalalgia 2005;25:776–87.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">15. Goldstein J., Silberstein S.D., Saper J.R., et al. Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, doubleblind, randomized, parallel-group, single-dose, placebo-controlled study. Headache 2006; 46:444–53.</mixed-citation><mixed-citation xml:lang="ru">Goldstein J., Silberstein S.D., Saper J.R., et al. Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, doubleblind, randomized, parallel-group, single-dose, placebo-controlled study. Headache 2006; 46:444–53.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">16. Limmroth V., May A., Diener H.C. Lysine-acetylsalicylic acid in acute migraine attacks. Eur Neurol 1999;41:88–93.</mixed-citation><mixed-citation xml:lang="ru">Limmroth V., May A., Diener H.C. Lysine-acetylsalicylic acid in acute migraine attacks. Eur Neurol 1999;41:88–93.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">17. Bigal M.E., Bordini C.A., Tepper S.J., Speciali J.G. Intravenous dipyrone in the acute treatment of migraine without aura and migraine with aura: a randomized, double blind, placebo controlled study. Headache 2002;42:862–71.</mixed-citation><mixed-citation xml:lang="ru">Bigal M.E., Bordini C.A., Tepper S.J., Speciali J.G. Intravenous dipyrone in the acute treatment of migraine without aura and migraine with aura: a randomized, double blind, placebo controlled study. Headache 2002;42:862–71.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">18. Tfelt-Hansen P., Henry P., Mulder L.J., et al. The effectiveness of combined oral lysine acetylsalicylate and metoclopramide compared with oral sumatriptan for migraine. Lancet 1995;</mixed-citation><mixed-citation xml:lang="ru">Tfelt-Hansen P., Henry P., Mulder L.J., et al. The effectiveness of combined oral lysine acetylsalicylate and metoclopramide compared with oral sumatriptan for migraine. Lancet 1995;</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">346:923–6.</mixed-citation><mixed-citation xml:lang="ru">:923–6.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">19. Diener H.C, Bussone G., de Liano H., et al. Placebo-controlled comparison of effervescent acetylsalicylic acid, sumatriptan and ibuprofen in the treatment of migraine attacks. Cephalalgia</mixed-citation><mixed-citation xml:lang="ru">Diener H.C, Bussone G., de Liano H., et al. Placebo-controlled comparison of effervescent acetylsalicylic acid, sumatriptan and ibuprofen in the treatment of migraine attacks. Cephalalgia</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">2004;24:947–54.</mixed-citation><mixed-citation xml:lang="ru">;24:947–54.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">20. Lampl C., Voelker M., Diener H.C. Efficacy and safety of 1000 mg effervescent aspirin: individual patient data meta-analysis of three trials in migraine headache and migraine accompanying symptoms. J Neurol 2007; 254:705–12.</mixed-citation><mixed-citation xml:lang="ru">Lampl C., Voelker M., Diener H.C. Efficacy and safety of 1000 mg effervescent aspirin: individual patient data meta-analysis of three trials in migraine headache and migraine accompanying symptoms. J Neurol 2007; 254:705–12.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">21. Обращение лекарственных средств. Реестр зарегистрированных лекарственных средств и типовых клинико-фармакологических статей. http://www.regmed.ru/</mixed-citation><mixed-citation xml:lang="ru">Обращение лекарственных средств. Реестр зарегистрированных лекарственных средств и типовых клинико-фармакологических статей. http://www.regmed.ru/</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">22. Энциклопедия лекарств и товаров аптечного ассортимента. http://www.rlsnet.ru/</mixed-citation><mixed-citation xml:lang="ru">Энциклопедия лекарств и товаров аптечного ассортимента. http://www.rlsnet.ru/</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">23. Waelkens J. Dopamine blockade with domperidone: bridge between prophylactic and abortive treatment of migraine? A dose-finding study. Cephalalgia 1984;4:85–90.</mixed-citation><mixed-citation xml:lang="ru">Waelkens J. Dopamine blockade with domperidone: bridge between prophylactic and abortive treatment of migraine? A dose-finding study. Cephalalgia 1984;4:85–90.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">24. Schulman E., Dermott K. Sumatriptan plus metoclopramide in triptan-nonresponsive migraineurs.</mixed-citation><mixed-citation xml:lang="ru">Schulman E., Dermott K. Sumatriptan plus metoclopramide in triptan-nonresponsive migraineurs.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><mixed-citation>Headache 2003;43:729–33.</mixed-citation></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">25. Friedman B.W., Corbo J., Lipton R.B., et al. A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines. Neurology 2005;64:463–8.</mixed-citation><mixed-citation xml:lang="ru">Friedman B.W., Corbo J., Lipton R.B., et al. A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines. Neurology 2005;64:463–8.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">26. A randomized, double-blind comparison of sumatriptan and Cafergot in the acute treatment of migraine. The Multinational Oral Sumatriptan and Cafergot Comparative Study Group. Eur Neurol 1991;31:314–22.</mixed-citation><mixed-citation xml:lang="ru">A randomized, double-blind comparison of sumatriptan and Cafergot in the acute treatment of migraine. The Multinational Oral Sumatriptan and Cafergot Comparative Study Group. Eur Neurol 1991;31:314–22.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">27. Christie S., Gobel H., Mateos V., et al. Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine/caffeine in migraine. Eur Neurol 2003;49:20–9.</mixed-citation><mixed-citation xml:lang="ru">Christie S., Gobel H., Mateos V., et al. Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine/caffeine in migraine. Eur Neurol 2003;49:20–9.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">28. Diener H.C., Reches A., Pascual J. et al. Efficacy, tolerability and safety of oral eletriptan and ergotamine plus caffeine (Cafergot) in the acute treatment of migraine: a multicentre, randomised,</mixed-citation><mixed-citation xml:lang="ru">Diener H.C., Reches A., Pascual J. et al. Efficacy, tolerability and safety of oral eletriptan and ergotamine plus caffeine (Cafergot) in the acute treatment of migraine: a multicentre, randomised,</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><mixed-citation>double-blind, placebo controlled comparison. Eur Neurol 2002;47:99–107.</mixed-citation></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">29. Lainez M.J., Galvan J., Heras J., Vila C. Crossover, double-blind clinical trial comparing almotriptan and ergotamine plus caffeine for acute migraine therapy. Eur J Neurol 2007; 14:269–75.</mixed-citation><mixed-citation xml:lang="ru">Lainez M.J., Galvan J., Heras J., Vila C. Crossover, double-blind clinical trial comparing almotriptan and ergotamine plus caffeine for acute migraine therapy. Eur J Neurol 2007; 14:269–75.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">30. Ferrari M.D., Roon K.I., Lipton R.B., Goadsby P.J. Oral triptans (serotonin 5-HT1B/1D agonists) in acute migraine treatment: a meta-analysis of 53 trials. Lancet 2001;358:1668–75.</mixed-citation><mixed-citation xml:lang="ru">Ferrari M.D., Roon K.I., Lipton R.B., Goadsby P.J. Oral triptans (serotonin 5-HT1B/1D agonists) in acute migraine treatment: a meta-analysis of 53 trials. Lancet 2001;358:1668–75.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">31. Goadsby P.B., Lipton R.B., Ferrai M.D. Migraine: current understanding and treatment. N Engl J Med 2002;346:257–70.</mixed-citation><mixed-citation xml:lang="ru">Goadsby P.B., Lipton R.B., Ferrai M.D. Migraine: current understanding and treatment. N Engl J Med 2002;346:257–70.</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">32. Diamond M., Hettiarachchi J., Hilliard B., et al. Effectiveness of eletriptan in acute migraine: primary care for Excedrin nonresponders. Headache 2004;44:209–16.</mixed-citation><mixed-citation xml:lang="ru">Diamond M., Hettiarachchi J., Hilliard B., et al. Effectiveness of eletriptan in acute migraine: primary care for Excedrin nonresponders. Headache 2004;44:209–16.</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">33. Bigal M.E., Serrano D., Buse D., et al. Acute migraine medications and evolution from episodic to chronic migraine: a longitudinal population-based study. Headache 2008;48:1157–68.</mixed-citation><mixed-citation xml:lang="ru">Bigal M.E., Serrano D., Buse D., et al. Acute migraine medications and evolution from episodic to chronic migraine: a longitudinal population-based study. Headache 2008;48:1157–68.</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">34. Limmroth V., Kazarawa S., Fritsche G., Diener H.C. Headache after frequent use of new serotonin agonists zolmitriptan and naratriptan. Lancet 1999;353:378.</mixed-citation><mixed-citation xml:lang="ru">Limmroth V., Kazarawa S., Fritsche G., Diener H.C. Headache after frequent use of new serotonin agonists zolmitriptan and naratriptan. Lancet 1999;353:378.</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">35. Katsarava Z., Fritsche G., Muessig M., et al. Clinical features of withdrawal headache following overuse of triptans and other headache drugs. Neurology 2001;57:1694–8.</mixed-citation><mixed-citation xml:lang="ru">Katsarava Z., Fritsche G., Muessig M., et al. Clinical features of withdrawal headache following overuse of triptans and other headache drugs. Neurology 2001;57:1694–8.</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">36. Данилов А.Б., Глембоцкая Г.Т., Козуб О.В. Фармакоэкономические аспекты мигрени. Журнал неврологии и психиатрии им. С.С. Корсакова 2011;(4):79–81.</mixed-citation><mixed-citation xml:lang="ru">Данилов А.Б., Глембоцкая Г.Т., Козуб О.В. Фармакоэкономические аспекты мигрени. Журнал неврологии и психиатрии им. С.С. Корсакова 2011;(4):79–81.</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">37. Brandes J.L., Kudrow D., Stark S.R., et al. Sumatriptan-naproxen for acute treatment of migraine: a randomized trial. JAMA 2007;297:1443–54.</mixed-citation><mixed-citation xml:lang="ru">Brandes J.L., Kudrow D., Stark S.R., et al. Sumatriptan-naproxen for acute treatment of migraine: a randomized trial. JAMA 2007;297:1443–54.</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">38. O’Quinn S., Davis R.L., Guttermann D.L., et al. Prospective large-scale study of the tolerability of subcutaneous sumatriptan injection for the acute treatment of migraine. Cephalalgia 1999;19:223–31.</mixed-citation><mixed-citation xml:lang="ru">O’Quinn S., Davis R.L., Guttermann D.L., et al. Prospective large-scale study of the tolerability of subcutaneous sumatriptan injection for the acute treatment of migraine. Cephalalgia 1999;19:223–31.</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">39. Welch K.M., Mathew N.T., Stone P., et al. Tolerability of sumatriptan: clinical trials and post-marketing experience. Cephalalgia 2000;20:687–95.</mixed-citation><mixed-citation xml:lang="ru">Welch K.M., Mathew N.T., Stone P., et al. Tolerability of sumatriptan: clinical trials and post-marketing experience. Cephalalgia 2000;20:687–95.</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><citation-alternatives><mixed-citation xml:lang="en">40. Velentgas P., Cole J.A., Mo J., et al. Severe vascular events in migraine patients. Headache 2004;44:642–51.</mixed-citation><mixed-citation xml:lang="ru">Velentgas P., Cole J.A., Mo J., et al. Severe vascular events in migraine patients. Headache 2004;44:642–51.</mixed-citation></citation-alternatives></ref><ref id="B47"><label>47.</label><citation-alternatives><mixed-citation xml:lang="en">41. Hall G., Brown M., Mo J., MacRae K.D. Triptans in migraine: the risks of stroke, cardiovascular disease, and death in practice. Neurology 2004;62:563–8.</mixed-citation><mixed-citation xml:lang="ru">Hall G., Brown M., Mo J., MacRae K.D. Triptans in migraine: the risks of stroke, cardiovascular disease, and death in practice. Neurology 2004;62:563–8.</mixed-citation></citation-alternatives></ref><ref id="B48"><label>48.</label><citation-alternatives><mixed-citation xml:lang="en">42. Treatment of migraine attacks with sumatriptan. The Subcutaneous Sumatriptan International Study Group. N Engl J Med 1991; 325:316–21.</mixed-citation><mixed-citation xml:lang="ru">Treatment of migraine attacks with sumatriptan. The Subcutaneous Sumatriptan International Study Group. N Engl J Med 1991; 325:316–21.</mixed-citation></citation-alternatives></ref><ref id="B49"><label>49.</label><citation-alternatives><mixed-citation xml:lang="en">43. Tepper S.J., Cochran A., Hobbs S., Woessner M. Sumatriptan suppositories for the acute treatment of migraine. Int J Clin Pract 1998;52:31–5.</mixed-citation><mixed-citation xml:lang="ru">Tepper S.J., Cochran A., Hobbs S., Woessner M. Sumatriptan suppositories for the acute treatment of migraine. Int J Clin Pract 1998;52:31–5.</mixed-citation></citation-alternatives></ref><ref id="B50"><label>50.</label><citation-alternatives><mixed-citation xml:lang="en">44. Tfelt-Hansen P., Ryan R.E. Jr. Oral therapy for migraine: comparisons between rizatriptan</mixed-citation><mixed-citation xml:lang="ru">Tfelt-Hansen P., Ryan R.E. Jr. Oral therapy for migraine: comparisons between rizatriptan</mixed-citation></citation-alternatives></ref><ref id="B51"><label>51.</label><mixed-citation>and sumatriptan. A review of four randomized, double-blind clinical trials. Neurology 2000;</mixed-citation></ref><ref id="B52"><label>52.</label><citation-alternatives><mixed-citation xml:lang="en">55(9 Suppl 2):19–24.</mixed-citation><mixed-citation xml:lang="ru">(9 Suppl 2):19–24.</mixed-citation></citation-alternatives></ref><ref id="B53"><label>53.</label><citation-alternatives><mixed-citation xml:lang="en">45. Leniger T., Pageler L., Stude P., et al. Comparison of intravenous valproate with intravenous lysine-acetylsalicylic acid in acute migraine attacks. Headache 2005;45:42–6.</mixed-citation><mixed-citation xml:lang="ru">Leniger T., Pageler L., Stude P., et al. Comparison of intravenous valproate with intravenous lysine-acetylsalicylic acid in acute migraine attacks. Headache 2005;45:42–6.</mixed-citation></citation-alternatives></ref><ref id="B54"><label>54.</label><citation-alternatives><mixed-citation xml:lang="en">46. Soyka D., Taneri Z., Oestreich W., Schmidt R. Flunarizine i.v. in the acute treatment of the migraine attack. A double-blind placebo-controlled study. Cephalalgia 1988;8(Suppl 8):35–40.</mixed-citation><mixed-citation xml:lang="ru">Soyka D., Taneri Z., Oestreich W., Schmidt R. Flunarizine i.v. in the acute treatment of the migraine attack. A double-blind placebo-controlled study. Cephalalgia 1988;8(Suppl 8):35–40.</mixed-citation></citation-alternatives></ref><ref id="B55"><label>55.</label><citation-alternatives><mixed-citation xml:lang="en">47. Holroyd K.A., Penzien D.B., Cordingley G.E. Propranolol in the management of recurrent migraine: a metaanalytic review. Headache 1991;31:333–40.</mixed-citation><mixed-citation xml:lang="ru">Holroyd K.A., Penzien D.B., Cordingley G.E. Propranolol in the management of recurrent migraine: a metaanalytic review. Headache 1991;31:333–40.</mixed-citation></citation-alternatives></ref><ref id="B56"><label>56.</label><citation-alternatives><mixed-citation xml:lang="en">48. van de Ven L.L., Franke C.L., Koehler P.J. Prophylactic treatment of migraine with bisoprolol: a placebo-controlled study. Cephalalgia 1997;17:596–9.</mixed-citation><mixed-citation xml:lang="ru">van de Ven L.L., Franke C.L., Koehler P.J. Prophylactic treatment of migraine with bisoprolol: a placebo-controlled study. Cephalalgia 1997;17:596–9.</mixed-citation></citation-alternatives></ref><ref id="B57"><label>57.</label><citation-alternatives><mixed-citation xml:lang="en">49. Diener H., Matias-Guiu J., Hartung E., et al. Efficacy and tolerability in migraine prophylaxis of flunarizine in reduced doses: a comparison with propranolol 160 mg daily. Cephalalgia 2002;22:209–21.</mixed-citation><mixed-citation xml:lang="ru">Diener H., Matias-Guiu J., Hartung E., et al. Efficacy and tolerability in migraine prophylaxis of flunarizine in reduced doses: a comparison with propranolol 160 mg daily. Cephalalgia 2002;22:209–21.</mixed-citation></citation-alternatives></ref><ref id="B58"><label>58.</label><citation-alternatives><mixed-citation xml:lang="en">50. Freitag F., Collins S., Carlson H. et al. A randomized trial of divalproex sodium extended-release tablets in migraine prophylaxis. Neurology 2002;58:1652–9.</mixed-citation><mixed-citation xml:lang="ru">Freitag F., Collins S., Carlson H. et al. A randomized trial of divalproex sodium extended-release tablets in migraine prophylaxis. Neurology 2002;58:1652–9.</mixed-citation></citation-alternatives></ref><ref id="B59"><label>59.</label><citation-alternatives><mixed-citation xml:lang="en">51. Silberstein S.D., Lipton R.B., Dodick D.W., et al. Efficacy and safety of topiramate for the treatment of chronic migraine: a randomized, double-blind, placebo-controlled trial. Headache 2007;47:170–80.</mixed-citation><mixed-citation xml:lang="ru">Silberstein S.D., Lipton R.B., Dodick D.W., et al. Efficacy and safety of topiramate for the treatment of chronic migraine: a randomized, double-blind, placebo-controlled trial. Headache 2007;47:170–80.</mixed-citation></citation-alternatives></ref><ref id="B60"><label>60.</label><citation-alternatives><mixed-citation xml:lang="en">52. Lampl C., Buzath A., Klinger D., Neumann K. Lamotrigine in the prophylactic treatment of migraine aura — a pilot study. Cephalalgia 1999;19:58–63.</mixed-citation><mixed-citation xml:lang="ru">Lampl C., Buzath A., Klinger D., Neumann K. Lamotrigine in the prophylactic treatment of migraine aura — a pilot study. Cephalalgia 1999;19:58–63.</mixed-citation></citation-alternatives></ref><ref id="B61"><label>61.</label><citation-alternatives><mixed-citation xml:lang="en">53. Ziegler D.K., Hurwitz A., Preskorn S., et al. Propranolol and amitriptyline in prophylaxis of mi- graine: pharmacokinetic and therapeutic effects. Arch Neurol 1993;50:825–30.</mixed-citation><mixed-citation xml:lang="ru">Ziegler D.K., Hurwitz A., Preskorn S., et al. Propranolol and amitriptyline in prophylaxis of mi- graine: pharmacokinetic and therapeutic effects. Arch Neurol 1993;50:825–30.</mixed-citation></citation-alternatives></ref><ref id="B62"><label>62.</label><citation-alternatives><mixed-citation xml:lang="en">54. Silberstein S., Mathew N., Saper J., Jenkins S. Botulinum toxin type A as a migraine preventive</mixed-citation><mixed-citation xml:lang="ru">Silberstein S., Mathew N., Saper J., Jenkins S. Botulinum toxin type A as a migraine preventive</mixed-citation></citation-alternatives></ref><ref id="B63"><label>63.</label><mixed-citation>treatment. Headache 2000;40:445–50.</mixed-citation></ref><ref id="B64"><label>64.</label><citation-alternatives><mixed-citation xml:lang="en">55. Evers S., Afra J., Frese A., et al. EFNS guideline on the drug treatment of migraine —revised report of an EFNS task force. Eur J Neurol 2009;16:968–81.</mixed-citation><mixed-citation xml:lang="ru">Evers S., Afra J., Frese A., et al. EFNS guideline on the drug treatment of migraine —revised report of an EFNS task force. Eur J Neurol 2009;16:968–81.</mixed-citation></citation-alternatives></ref><ref id="B65"><label>65.</label><citation-alternatives><mixed-citation xml:lang="en">56. Sargent J., Solbach P., Damasio H., et al. A comparison of naproxen sodium to propranolol hydrochloride and a placebo control for the prophylaxis of migraine headache. Headache 1985;25:320–4.</mixed-citation><mixed-citation xml:lang="ru">Sargent J., Solbach P., Damasio H., et al. A comparison of naproxen sodium to propranolol hydrochloride and a placebo control for the prophylaxis of migraine headache. Headache 1985;25:320–4.</mixed-citation></citation-alternatives></ref><ref id="B66"><label>66.</label><citation-alternatives><mixed-citation xml:lang="en">57. Mannix L.K., Savani N., Landy S., et al. Efficacy and tolerability of naratriptan for shortterm prevention of menstrually related migraine: data from two randomized, double-blind, placebo-controlled studies. Headache 2007;47:1037–49.</mixed-citation><mixed-citation xml:lang="ru">Mannix L.K., Savani N., Landy S., et al. Efficacy and tolerability of naratriptan for shortterm prevention of menstrually related migraine: data from two randomized, double-blind, placebo-controlled studies. Headache 2007;47:1037–49.</mixed-citation></citation-alternatives></ref><ref id="B67"><label>67.</label><citation-alternatives><mixed-citation xml:lang="en">58. Evers S., Kropp P., Pothmann R., et al. Therapie idiopathischer Kopfschmerzen im Kindes- und Jugendalter. Nervenheilkunde 2008;27:1127–37.</mixed-citation><mixed-citation xml:lang="ru">Evers S., Kropp P., Pothmann R., et al. Therapie idiopathischer Kopfschmerzen im Kindes- und Jugendalter. Nervenheilkunde 2008;27:1127–37.</mixed-citation></citation-alternatives></ref><ref id="B68"><label>68.</label><citation-alternatives><mixed-citation xml:lang="en">59. Evers S. Drug treatment of migraine in children. A comparative review. Paediatr Drugs 1999;1:7–18.</mixed-citation><mixed-citation xml:lang="ru">Evers S. Drug treatment of migraine in children. A comparative review. Paediatr Drugs 1999;1:7–18.</mixed-citation></citation-alternatives></ref><ref id="B69"><label>69.</label><citation-alternatives><mixed-citation xml:lang="en">60. Lewis D., Ashwal S., Hershey A., et al. Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology 2004;63:2215–24.</mixed-citation><mixed-citation xml:lang="ru">Lewis D., Ashwal S., Hershey A., et al. Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology 2004;63:2215–24.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
