The ClinicianThe ClinicianКлиницист1818-83382412-8775Publishing House ABV Press7510.17650/1818-8338-2012-1-81-85PHARMACOTHERAPYФАРМАКОТЕРАПИЯEVIDENCE-BASED USE OF EPLERENONEДОКАЗАТЕЛЬНЫЕ ОСНОВЫ ПРИМЕНЕНИЯ ЭПЛЕРЕНОНАGilyarevskiS. R.ГиляревскийC. Р.
Russian Federation
sgilarevsky@rambler.ruOrlovV. A.ОрловВ. А.
Russian Federation

Department of Clinical Pharmacology and Therapeutics

кафедра клинической фармакологии и терапии

KuzminaI. M.КузьминаИ. М.
Russian Federation
GolshmidM. V.ГолшмидМ. В.
Russian Federation

Department of Clinical Pharmacology and Therapeutics

кафедра клинической фармакологии и терапии

ZakharovaG. Y.ЗахароваГ. Ю.
Russian Federation

Department of Clinical Pharmacology and Therapeutics

кафедра клинической фармакологии и терапии

SinitsinaI. I.СиницинаИ. И.
Russian Federation

Department of Clinical Pharmacology and Therapeutics

кафедра клинической фармакологии и терапии

Sklifosovsky Institute of Emergency SurgeryНИИ скорой помощи им. Н.В. СклифосовскогоРМАПОНИИ скорой помощи им. Н.В. СклифосовскогоSklifosovsky Institute of Emergency SurgeryРМАПО150120126181851607201416072014Copyright ©; 2012, Gilyarevski S.R., Orlov V.A., Kuzmina I.M., Golshmid M.V., Zakharova G.Y., Sinitsina I.I.Copyright ©; 2012, Гиляревский C.Р., Орлов В.А., Кузьмина И.М., Голшмид М.В., Захарова Г.Ю., Синицина И.И.2012Gilyarevski S.R., Orlov V.A., Kuzmina I.M., Golshmid M.V., Zakharova G.Y., Sinitsina I.I.Гиляревский C.Р., Орлов В.А., Кузьмина И.М., Голшмид М.В., Захарова Г.Ю., Синицина И.И.https://creativecommons.org/licenses/by/4.0https://klinitsist.abvpress.ru/Klin/article/view/75

Data of the negative effect of high concentrations of aldosterone in the blood for cardiovascular disease, which served as the theoretical basis for wider use in clinical practice of the drugs belonging to the class of aldosterone receptor blockers is presented. Evidence-based data on efficacy and safety of aldosterone receptor blockers, which were obtained in the course of several randomized clinical trials is performed. Particular attention is paid to aspects of the clinical use of selective aldosterone receptor blocker eplerenone, including current data, which makes reasonable extension of indications for its use in treating patients with chronic heart failure. Data on indications of eplerenone use in patients with hypertension, especially in the case of associated target organ damage is presented.

Приведены данные об отрицательном влиянии повышенной концентрации альдостерона в крови на течение сердечно-сосудистых заболеваний, послужившие теоретическим основанием для более широкого использования в клинической практике препаратов, относящихся к классу блокаторов рецепторов альдостерона. Представлены доказательства эффективности и безопасности применения блокаторов рецепторов альдостерона, которые были получены в ходе выполнения нескольких рандомизированных клинических испытаний. Особое внимание уделено аспектам клинического использования селективного блокатора рецепторов альдостерона эплеренона, в том числе современным данным, которые делают обоснованным расширение показаний для применения его в лечении больных с хронической сердечной недостаточностью. Приведены данные о показаниях к применению эплеренона у больных с артериальной гипертонией, особенно в случае сопутствующего поражения органов-мишеней.

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