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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">The Clinician</journal-id><journal-title-group><journal-title xml:lang="en">The Clinician</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиницист</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8338</issn><issn publication-format="electronic">2412-8775</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">615</article-id><article-id pub-id-type="doi">10.17650/1818-8338-2024-18-3-K722</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CASE REPORT</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОПИСАНИЕ СЛУЧАЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Infective endocarditis in injection drug users: disease course, diagnostic and clinical aspects (clinical case analysis)</article-title><trans-title-group xml:lang="ru"><trans-title>Инфекционный эндокардит «инъекционных» наркоманов: течение, особенности диагностики и лечения (клинический разбор случая заболевания)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9255-8831</contrib-id><name-alternatives><name xml:lang="en"><surname>Makhnyr</surname><given-names>E. F.</given-names></name><name xml:lang="ru"><surname>Махнырь</surname><given-names>Е. Ф.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Elena Fedorovna Mahnyr, . A.I. Nesterov Department of Faculty Therapy of Faculty of Medicine</p><p>1 Ostrovityanova St., Moscow 117997</p></bio><bio xml:lang="ru"><p>Елена Федоровна Махнырь, кафедра факультетской терапии им. акад. А.И. Нестерова лечебного факультета</p><p>117997 Москва, ул. Островитянова, 1</p><p>117049 Москва, Ленинский просп., 8</p></bio><email>dochelen@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-1538-4530</contrib-id><name-alternatives><name xml:lang="en"><surname>Kazakovtseva</surname><given-names>T. A.</given-names></name><name xml:lang="ru"><surname>Казаковцева</surname><given-names>Т. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>8 Leninskiy Avenue, Moscow 117049, Russia</p></bio><bio xml:lang="ru"><p>117049 Москва, Ленинский просп., 8</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2083-0437</contrib-id><name-alternatives><name xml:lang="en"><surname>Chipigina</surname><given-names>N. S.</given-names></name><name xml:lang="ru"><surname>Чипигина</surname><given-names>Н. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A.I. Nesterov Department of Faculty Therapy of Faculty of Medicine</p><p>1 Ostrovityanova St., Moscow 117997</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А.И.  Нестерова лечебного факультета</p><p>117997 Москва, ул. Островитянова, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7410-9784</contrib-id><name-alternatives><name xml:lang="en"><surname>Klimenko</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Клименко</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A.I. Nesterov Department of Faculty Therapy of Faculty of Medicine</p><p>1 Ostrovityanova St., Moscow 117997</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А.И. Нестерова лечебного факультета</p><p>117997 Москва, ул. Островитянова, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7841-8966</contrib-id><name-alternatives><name xml:lang="en"><surname>Karpova</surname><given-names>N. Yu.</given-names></name><name xml:lang="ru"><surname>Карпова</surname><given-names>Н. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A.I. Nesterov Department of Faculty Therapy of Faculty of Medicine</p><p>1 Ostrovityanova St., Moscow 117997</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А.И. Нестерова лечебного факультета</p><p>117997 Москва, ул. Островитянова, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6462-0899</contrib-id><name-alternatives><name xml:lang="en"><surname>Anishchenko</surname><given-names>M. O.</given-names></name><name xml:lang="ru"><surname>Анищенко</surname><given-names>М. О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A.I. Nesterov Department of Faculty Therapy of Faculty of Medicine</p><p>1 Ostrovityanova St., Moscow 117997</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А.И. Нестерова лечебного факультета</p><p>117997 Москва, ул. Островитянова, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5675-9487</contrib-id><name-alternatives><name xml:lang="en"><surname>Morits</surname><given-names>V.</given-names></name><name xml:lang="ru"><surname>Мориц</surname><given-names>В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A.I. Nesterov Department of Faculty Therapy of Faculty of Medicine</p><p>1 Ostrovityanova St., Moscow 117997</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А.И. Нестерова лечебного факультета</p><p>117997 Москва, ул. Островитянова, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.I. Pirogov National Research Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">N.I. Pirogov City Clinical Hospital No.1, Moscow Healthcare Department</institution></aff><aff><institution xml:lang="ru">ГБУЗ города Москвы «Городская клиническая больница №1 им. Н.И. Пирогова Департамента здравоохранения города Москвы»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-07-15" publication-format="electronic"><day>15</day><month>07</month><year>2024</year></pub-date><volume>18</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>38</fpage><lpage>47</lpage><history><date date-type="received" iso-8601-date="2024-11-29"><day>29</day><month>11</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-11-29"><day>29</day><month>11</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Makhnyr E.F., Kazakovtseva T.A., Chipigina N.S., Klimenko A.A., Karpova N.Y., Anishchenko M.O., Morits V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Махнырь Е.Ф., Казаковцева Т.А., Чипигина Н.С., Клименко А.А., Карпова Н.Ю., Анищенко М.О., Мориц В.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Makhnyr E.F., Kazakovtseva T.A., Chipigina N.S., Klimenko A.A., Karpova N.Y., Anishchenko M.O., Morits V.</copyright-holder><copyright-holder xml:lang="ru">Махнырь Е.Ф., Казаковцева Т.А., Чипигина Н.С., Клименко А.А., Карпова Н.Ю., Анищенко М.О., Мориц В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://klinitsist.abvpress.ru/Klin/article/view/615">https://klinitsist.abvpress.ru/Klin/article/view/615</self-uri><abstract xml:lang="en"><p><bold>Aim.</bold> To present and clinically analyze a case of “injection drug users” infective endocarditis (IE) to increase awareness among general practitioners and cardiologists about this special variant of IE.</p><p><bold>Materials and methods.</bold> Clinical observation of a 39-year-old female patient with long-term heroin and methadone addiction, viral hepatitis C, who was diagnosed with acute primary IE caused by methicillin-sensitive Staphylococcus aureus localized on the tricuspid and mitral valves. Bilateral septic pulmonary embolism and respiratory failure, secondary anemia, thrombocytopenia, nephrotic syndrome due to secondary glomerulonephritis were observed. On the 21st day of treatment, the patient underwent tricuspid valve replacement surgery with a biological prosthesis and multicomponent reconstruction of the mitral valve, the postoperative period was complicated by the development of exudative pericarditis.</p><p><bold>Results.</bold> The clinical picture and the course of a complex case of “injection drug users” IE are discussed. The difficulties of early diagnostics of IE caused by the absence of pathognomonic clinical manifestations of the disease and the variability of the debuts of IE with the prevalence of extracardiac manifestations is highlighted. The principles of antibacterial therapy and indications for surgical treatment are reviewed.</p><p><bold>Conclusion.</bold> Clinical observation draws the attention to the high probability of diagnosing IE in cases of fever in intravenous drug users and demonstrates both the difficulties of treatment and the possibility of a favorable outcome of this serious disease with timely diagnosis, appropriate antibacterial therapy, and early cardiac surgery.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель работы</bold> - представление и клинический разбор случая инфекционного эндокардита (ИЭ) «инъекционных» наркоманов для повышения осведомленности врачей-терапевтов и кардиологов об особом варианте ИЭ.</p><p><bold>Материалы и методы.</bold> Клиническое наблюдение пациентки 39 лет с длительной героиновой и метадоновой наркоманией, вирусным гепатитом С, у которой был диагностирован острый первичный ИЭ, вызванный метициллинчувствительным Staphylococcus aureus, с локализацией на трикуспидальном и митральном клапанах. Заболевание протекало с двусторонней полисегментарной септической эмбологенной пневмонией и дыхательной недостаточностью, вторичной анемией, тромбоцитопенией, нефротическим синдромом вследствие вторичного гломерулонефрита. На 21-е сутки лечения пациентке были выполнены операция протезирования трикуспидального клапана биологическим протезом и многокомпонентная реконструкция митрального клапана, послеоперационный период осложнился развитием экссудативного перикардита.</p><p><bold>Результаты.</bold> Обсуждены клиническая картина и особенности течения сложного случая ИЭ «инъекционных» наркоманов. Выделена проблема ранней диагностики ИЭ, обусловленная отсутствием патогномоничных клинических проявлений заболевания и вариабельностью дебюта ИЭ с преобладанием в клинической картине внесердечных проявлений. Рассмотрены принципы антибактериальной терапии и показания к хирургическому лечению.</p><p><bold>Заключение.</bold> Клиническое наблюдение обращает внимание врачей на высокую вероятность диагностики ИЭ в случаях лихорадки у «инъекционных» наркоманов и демонстрирует как трудности лечения, так и возможность благоприятного исхода этого тяжелого заболевания при своевременной диагностике, этиотропной антибактериальной терапии и раннем кардиохирургическом вмешательстве. </p></trans-abstract><kwd-group xml:lang="en"><kwd>infective endocarditis in injection drug users</kwd><kwd>septic pulmonary embolism</kwd><kwd>secondary glomerulonephritis</kwd><kwd>nephrotic syndrome</kwd><kwd>acute kidney injury syndrome</kwd><kwd>exudative pericarditis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>инфекционный эндокардит «инъекционных» наркоманов</kwd><kwd>септическая эмбологенная пневмония</kwd><kwd>вторичный гломерулонефрит</kwd><kwd>нефротический синдром</kwd><kwd>синдром острого повреждения почек</kwd><kwd>экссудативный перикардит</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Frontera J.A., Gradon J.D. 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