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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">The Clinician</journal-id><journal-title-group><journal-title xml:lang="en">The Clinician</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиницист</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8338</issn><issn publication-format="electronic">2412-8775</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">612</article-id><article-id pub-id-type="doi">10.17650/1818-8338-2024-18-3-K721</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Psoriatic arthritis (literature review)</article-title><trans-title-group xml:lang="ru"><trans-title>Псориатический артрит (обзор литературы)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2025-8119</contrib-id><name-alternatives><name xml:lang="en"><surname>Asfandiyarova</surname><given-names>N. S.</given-names></name><name xml:lang="ru"><surname>Асфандиярова</surname><given-names>Н. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p> Nailya Sayfullaevna Asfandiyarova</p><p>9 Vysokovoltnaya St., Ryazan 390026</p></bio><bio xml:lang="ru"><p>Наиля Сайфуллаевна Асфандиярова</p><p>390026 Рязань, ул. Высоковольтная, 9</p></bio><email>n.asfandiyarova2010@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8969-806X</contrib-id><name-alternatives><name xml:lang="en"><surname>Shilin</surname><given-names>R. R.</given-names></name><name xml:lang="ru"><surname>Шилин</surname><given-names>Р. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>9 Vysokovoltnaya St., Ryazan 390026</p></bio><bio xml:lang="ru"><p>390026 Рязань, ул. Высоковольтная, 9</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.P. Pavlov Ryazan State Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Рязанский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-07-15" publication-format="electronic"><day>15</day><month>07</month><year>2024</year></pub-date><volume>18</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>10</fpage><lpage>20</lpage><history><date date-type="received" iso-8601-date="2024-11-29"><day>29</day><month>11</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-11-29"><day>29</day><month>11</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Asfandiyarova N.S., Shilin R.R.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Асфандиярова Н.С., Шилин Р.Р.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Asfandiyarova N.S., Shilin R.R.</copyright-holder><copyright-holder xml:lang="ru">Асфандиярова Н.С., Шилин Р.Р.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://klinitsist.abvpress.ru/Klin/article/view/612">https://klinitsist.abvpress.ru/Klin/article/view/612</self-uri><abstract xml:lang="en"><p>Psoriatic arthritis (PsA) is a chronic immune-inflammatory progressive disease of the musculoskeletal system observed in psoriasis, which affects the joints, spine and entheses; it occurs in the form of arthritis, dactylitis, enthesitis, and can also manifest as spondylitis or sacroiliitis. The etiology of PsA is unknown, but the pathogenesis has been studied in more detail. Under the influence of external factors, such as infectious agents (viruses, bacteria, fungi), neuropsychic stress, injuries, drugs, changes in intestinal microbiota, etc., genetically predisposed individuals experience activation of the immune system, both congenital and acquired. Currently, there are 5 clinical forms of PsA: predominantly lesion of the distal interphalangeal joints of the hands and feet, distal form; mutilating arthritis; psoriatic spondylitis; asymmetric mono-oligoarthritis; symmetrical polyarthritis, rheumatoid-like form. Along with the characteristic symptomsof skin and joint damage, patients with PsA note a decrease in the quality of life, general malaise, fever, enlarged lymph Review nodes, weight loss, signs of comorbid pathology (obesity, diabetes, cardiovascular diseases). Arthritis is accompanied by tendinitis, synovitis, enthesitis. Isolated spinal damage (psoriatic spondylitis) is rare, it is usually combined with peripheral arthritis, characterized by pain in the spine, dysfunction, curvature. Differential diagnostics are carried out with rheumatoid arthritis, gout, ankylosing spondylitis, polyosteoarthritis, infectious forms of joint damage, joint damage in chronic inflammatory bowel diseases. Treatment of PsA should include medication, physiotherapy and spa treatment. Usually, treatment of PsA begins with the use of such drugs as methotrexate, leflunomide, sulfasalazine, cyclosporine A; non-steroidal anti-inflammatory drugs and intra-articular administration of glucocorticosteroids are used as an auxiliary agent, they are classified as symptom-modifying drugs, they partially improve the patient’s quality of life, reduce pain, but have little effect on the progression of the pathological process. In the absence of an effect from previously conducted treatment and contraindications, genetically engineered biological drugs are used.</p></abstract><trans-abstract xml:lang="ru"><p>Псориатический артрит (ПА) представляет собой хроническое иммуновоспалительное прогрессирующее заболевание опорно-двигательного аппарата, наблюдаемое при псориазе, с вовлечением суставов (артрит), позвоночника (спондилит) и энтезов (энтезит). Этиология ПА неизвестна, однако патогенез изучен детально. Под влиянием внешних факторов, таких как инфекционные агенты (вирусы, бактерии, грибы), нервно-психический стресс, травмы, лекарственные препараты, изменение микробиоты кишечника и других, у генетически предрасположенных лиц наблюдается активация системы иммунитета как врожденного, так и приобретенного. В настоящее время выделяют 5 клинических форм ПА: преимущественное поражение дистальных межфаланговых суставов кистей и стоп, дистальная форма; мутилирующий артрит; псориатический спондилит; асимметричный моно-олигоартрит; симметричный полиартрит, ревматоидоподобная форма. Наряду с характерными симптомами поражения кожи и суставов, пациенты с ПА отмечают снижение качества жизни, общее недомогание, повышение температуры тела, увеличение лимфатических узлов, снижение массы тела, встречаются признаки коморбидной патологии (ожирение, сахарный диабет, сердечно-сосудистые заболевания). Артриты сопровождаются тендинитами, синовитами, энтезитами. Изолированное поражение позвоночника (псориатический спондилит) встречается редко, обычно оно сочетается с периферическим артритом, характеризуется болями в позвоночнике, нарушением функции, деформациями позвоночника. Дифференциальная диагностика проводится с ревматоидным артритом, подагрой, анкилозирующим спондилитом, полиостеоартритом, инфекционными формами поражения суставов, поражением суставов при хронических воспалительных заболеваниях кишечника. Терапия ПА должна включать медикаментозное, физиотерапевтическое и санаторно-курортное лечение. Обычно лечение ПА начинают с использования таких препаратов, как метотрексат, лефлуномид, сульфасалазин, циклоспорин А. Как вспомогательные средства используют нестероидные противовоспалительные препараты и внутрисуставное введение глюкокортикоидов, их относят к симптомомодифицирующим препаратам, они частично улучшают качество жизни пациента, уменьшают боль, но мало влияют на прогрессирование патологического процесса. При отсутствии эффекта от ранее проводимого лечения используют генно-инженерные биологические препараты.</p></trans-abstract><kwd-group xml:lang="en"><kwd>psoriatic arthritis</kwd><kwd>classification</kwd><kwd>pathogenesis</kwd><kwd>innate immunity</kwd><kwd>cellular immunity</kwd><kwd>humoral immunity</kwd><kwd>clinical presentation</kwd><kwd>diagnostics</kwd><kwd>treatment</kwd><kwd>genetically engineered biological drug</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>псориатический артрит</kwd><kwd>классификация</kwd><kwd>патогенез</kwd><kwd>врожденный иммунитет</kwd><kwd>клеточный иммунитет</kwd><kwd>гуморальный иммунитет</kwd><kwd>клиника</kwd><kwd>диагностика</kwd><kwd>лечение</kwd><kwd>генно-инженерный биологический препарат</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Znamenskaya L.F., Melekhina L.E., Bogdanova E.V. et al. 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