The ClinicianThe ClinicianКлиницист1818-83382412-8775Publishing House ABV Press6010.17650/1818-8338-2012-3-4-73-79PHARMACOTHERAPYФАРМАКОТЕРАПИЯEffect of renin-angiotensin -aldosterone system blockers on myocardial remodeling processes and risk for atrial fibrillation in patients with arterial hypertensionВлияние блокаторов ренин-ангиотензин -альдостероновой системы на процессы ремоделирования миокарда и риск фибрилляции предсердий у больных артериальной гипертензиейDrapkinaO. M.ДрапкинаО. М.
Russian Federation

Department of Internal Propedeutics, Faculty of Therapeutics

Кафедра пропедевтики внутренних болезней лечебного факультета

drapkina@bk.ruKostyukevichM. V.КостюкевичМ. В.
Russian Federation

Department of Internal Propedeutics, Faculty of Therapeutics

Кафедра пропедевтики внутренних болезней лечебного факультета

I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaГБОУ ВПО «Первый МГМУ им. И.М. Сеченова» Минздрава России1510201263-473791507201415072014Copyright ©; 2012, Drapkina O.M., Kostyukevich M.V.Copyright ©; 2012, Драпкина О.М., Костюкевич М.В.2012Drapkina O.M., Kostyukevich M.V.Драпкина О.М., Костюкевич М.В.https://creativecommons.org/licenses/by/4.0https://klinitsist.abvpress.ru/Klin/article/view/60

The given review considers the mechanisms underlying the development and maintenance of atrial fibrillations (AF). It is noted that the processes of atrial fibrosis, ion channel remodeling, inflammation, apoptosis, impaired intercellular interactions, and myocardiocyte hypertrophy may give rise to atrial structural and functional changes in AF. The efficacy of angiotensinonverting enzyme inhibitors and angiotensin receptor antagonists is justified in patients with left ventricular systolic dysfunction.

В представленном обзоре рассматриваются механизмы, лежащие в основе развития и поддержания фибрилляции предсердий (ФП). Отмечено, что в основе структурных и функциональных изменений в предсердиях при ФП могут лежать процессы фиброза предсердий, ремоделирования ионных каналов, воспаления, апоптоза, нарушения межклеточных взаимодействий, гипертрофии клеток миокарда. Обоснована эффективность ингибиторов ангиотензинпревращающего фермента и антагонистов рецепторов ангиотензина у пациентов с систолической дисфункцией левого желудочка.

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