The ClinicianThe ClinicianКлиницист1818-83382412-8775Publishing House ABV Press58710.17650/1818-8338-2024-18-1-K696REVIEWОБЗОРAtherosclerosis and inflammation: therapeutic targets and ways of correctionАтеросклероз и воспаление: терапевтические мишени и пути воздействияhttps://orcid.org/0000-0002-7410-9784KlimenkoA. A.КлименкоА. А.
Russian Federation

Аcad. A. I. Nesterov Department of Faculty Therapy of N.I.

1 Ostrovitianov St., Moscow 117997

Кафедра факультетской терапии им. акад. А.И. Нестерова лечебного факультета 

117997 Москва

https://orcid.org/0000-0001-8266-6022AndriyashkinaD. Yu.АндрияшкинаД. Ю.
Russian Federation

Daria Yurievna Andriyashkina

Аcad. A. I. Nesterov Department of Faculty Therapy of N.I.

1 Ostrovitianov St., Moscow 117997

Дарья Юрьевна Андрияшкина 

Кафедра факультетской терапии им. акад. А.И. Нестерова лечебного факультета 

117997 Москва

andryashkina.darya@yandex.ruhttps://orcid.org/0009-0003-6315-7697OgarkovaK. I.ОгарковаК. И.
Russian Federation

Аcad. A. I. Nesterov Department of Faculty Therapy of N.I.

1 Ostrovitianov St., Moscow 117997

Кафедра факультетской терапии им. акад. А.И. Нестерова лечебного факультета 

117997 Москва

Pirogov Russian National Research Medical University, Ministry of Health of RussiaФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России1501202418112302306202423062024Copyright ©; 2024, Klimenko A.A., Andriyashkina D.Y., Ogarkova K.I.Copyright ©; 2024, Клименко А.А., Андрияшкина Д.Ю., Огаркова К.И.2024Klimenko A.A., Andriyashkina D.Y., Ogarkova K.I.Клименко А.А., Андрияшкина Д.Ю., Огаркова К.И.https://creativecommons.org/licenses/by/4.0https://klinitsist.abvpress.ru/Klin/article/view/587

Atherosclerosis is a chronic inflammatory vascular disease caused by various risk factors, in particular smoking, obesity, high blood pressure, and dyslipidemia. In addition, such signaling pathways as NLRP3 inflammasome, toll-like receptors, proprotein convertase subtilisin/kexin type 9, Notch and Wnt, which are associated with the inflammatory response in the human body, are involved in the pathogenesis of atherosclerosis. Therapeutic targeting of inflammatory pathways, especially the NLRP3 inflammasome pathway and the cascade of reactions regulated by it leading to the production of inflammatory interleukin-1β, may represent a new avenue for the treatment of atherosclerotic diseases. This article summarizes knowledge of the cellular participants and key inflammatory signaling pathways in atherosclerosis, discusses preclinical studies targeting these key pathways in atherosclerosis, clinical trials that will target some of these processes, and the effects of suppressing inflammation and atherosclerosis.

Атеросклероз (АС) – это хроническое воспалительное заболевание сосудов, обусловленное различными факторами риска, в частности курением, ожирением, артериальной гипертензией, дислипидемией. Кроме того, в патогенез АС вовлечены такие сигнальные пути, как инфламмасома NLRP3, Toll-подобные рецепторы, пропротеин конвертаза субтилизина/кексина 9-го типа, Notch и Wnt, которые связаны с воспалительной реакцией в организме человека. Терапевтическое воздействие на воспалительные пути, особенно на каскад реакций, регулируемый инфламмасомой NLRP3 и приводящий к продукции воспалительного интерлейкина-1β, может представлять собой новый путь лечения АС-заболеваний. В статье обобщены знания о клеточных участниках и ключевых сигнальных путях воспаления при АС, обсуждаются доклинические исследования, нацеленные на эти ключевые пути развития АС, клинические испытания, которые будут направлены на некоторые из этих процессов и эффекты подавления воспаления и атерогенеза.

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