The ClinicianThe ClinicianКлиницист1818-83382412-8775Publishing House ABV Press57510.17650/1818-8338-2023-17-4-K687ORIGINAL INVESTIGATIONSОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕSerological markers of sarcopenia in ages 65 and overСерологические маркеры саркопении у людей в возрасте 65 лет и старшеhttps://orcid.org/0000-0003-2923-9712SafonovaYu. A.СафоноваЮ. А.
Russian Federation

Yuliya Alexandrovna Safonova

41 Kirochnaya St., St.­Petersburg 191015

30 Bolshaya Podyacheskaya St., St. Petersburg 190068

Юлия Александровна Сафонова

191015 Санкт-Петербург, Кирочная, 41

190068 Санкт-Петербург, Большая Подьяческая, 30

jula_safonova@mail.ruI.I. Mechnikov North-Western State Medical University, Health Ministry of RussiaФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииSt. Petersburg State Clinical Rheumatological Hospital No. 25СПб ГБУЗ «Клиническая ревматологическая больница №25»1510202317419262902202429022024Copyright ©; 2023, Safonova Y.A.Copyright ©; 2023, Сафонова Ю.А.2023Safonova Y.A.Сафонова Ю.А.https://creativecommons.org/licenses/by/4.0https://klinitsist.abvpress.ru/Klin/article/view/575

Aim. To determine serological markers of sarcopenia (SP) for use in general medical practice in people aged 65 years and older living independently.

Materials and methods. The study included 230 people aged 65 years and older (70 men and 160 women, median age 75 [68; 79] years) were consulted in a medical institution in St. Petersburg. The diagnosis of SP was made according to the criteria of EWGSOP2 (2018). The laboratory examination included clinical and biochemical blood analysis, determine the level of 25(OH)D, parathyroid hormone (PTH), C-reactive protein (CRP).

Results. The risk of SP increased at levels 25(OH)D less than 21 ng/mL (odds ratio 4.989; 95 % confidence interval 1.321–12.626; р = 0.0420), total protein less than 65 g/l (OR 8.567; 95 % CI 2.658–27.617; р = 0.00032), serum CRP 6 mg/l or more (OR 14.279; 95 % CI: 3.511–58.071; р = 0.00020) and decrease in the estimated glomerular filtration rate (eGFR) less than 62 ml/min/1.73 m2 (OR 12.108; 95 % CI 3.944–37.170; р = 0.00001).

Conclusion. Serological markers of SP, such as vitamin D, total protein, C-reactive protein in blood serum and eGFR can be used in general medical practice.

Цель исследования – определение серологических маркеров саркопении (СП) для использования в общей врачебной практике у людей в возрасте 65 лет и старше, проживающих самостоятельно.

Материалы и методы. В исследование включены 230 человек 65 лет и старше (70 мужчин и 160 женщин, медиана возраста 75 [68; 79] лет), обратившихся за консультативной помощью в медицинское учреждение Санкт-Петербурга. СП диагностировали по критериям Европейской рабочей группы по саркопении у пожилых людей (European Working Group on Sarcopenia in Older People, EWGSOP2, 2018 г.). Лабораторное исследование включало клинический и биохимический анализ крови, определение уровня 25(ОН)D (25-гидроксикальциферол), паратиреоидного гормона, С-реактивного белка (СРБ).

Результаты. Риск СП увеличивался при уровне 25(OH)D менее 21 нг/мл (отношение шансов (ОШ) 4,989; 95 % доверительный интервал (ДИ) 1,321–12,626; р = 0,04200), общего белка менее 65 г/л (ОШ 8,567; 95 % ДИ 2,658–27,617; р = 0,00032), СРБ в сыворотке крови 6 мг/л и более (ОШ 14,279; 95 % ДИ 3,511–58,071; р = 0,00020) и при снижении расчетной скорости клубочковой фильтрации менее 62 мл/мин/1,73 м2 (ОШ 12,108; 95 % ДИ 3,944–37,170; р = 0,00001).

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