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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">The Clinician</journal-id><journal-title-group><journal-title xml:lang="en">The Clinician</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиницист</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8338</issn><issn publication-format="electronic">2412-8775</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">549</article-id><article-id pub-id-type="doi">10.17650/1818-8338-2023-17-2-K683</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Features of the course of COVID-19 in pregnant women</article-title><trans-title-group xml:lang="ru"><trans-title>Особенности течения COVID-19 у беременных</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6064-560X</contrib-id><name-alternatives><name xml:lang="en"><surname>Grigoryeva</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Григорьева</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Elena Vyacheslavovna Grigorieva,</p><p>112 Bolshaya Kazachya St., Saratov  410012.</p></bio><bio xml:lang="ru"><p>Елена Вячеславовна Григорьева,</p><p>410012 Саратов, ул. Большая Казачья, 112.</p></bio><email>lek133@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7886-1175</contrib-id><name-alternatives><name xml:lang="en"><surname>Tyapkina</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Тяпкина</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>112 Bolshaya Kazachya St., Saratov  410012.</p></bio><bio xml:lang="ru"><p>410012 Саратов, ул. Большая Казачья, 112.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6632-5110</contrib-id><name-alternatives><name xml:lang="en"><surname>Boroday</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Бородай</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>112 Bolshaya Kazachya St., Saratov  410012.</p></bio><bio xml:lang="ru"><p>410012 Саратов, ул. Большая Казачья, 112.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3224-6913</contrib-id><name-alternatives><name xml:lang="en"><surname>Blokhin</surname><given-names>I. S.</given-names></name><name xml:lang="ru"><surname>Блохин</surname><given-names>И. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>112 Bolshaya Kazachya St., Saratov  410012.</p></bio><bio xml:lang="ru"><p>410012 Саратов, ул. Большая Казачья, 112.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8827-8143</contrib-id><name-alternatives><name xml:lang="en"><surname>Kondrashkin</surname><given-names>I. E.</given-names></name><name xml:lang="ru"><surname>Кондрашкин</surname><given-names>И. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>112 Bolshaya Kazachya St., Saratov  410012.</p></bio><bio xml:lang="ru"><p>410012 Саратов, ул. Большая Казачья, 112.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7538-7412</contrib-id><name-alternatives><name xml:lang="en"><surname>Polidanov</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Полиданов</surname><given-names>М. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>112 Bolshaya Kazachya St., Saratov  410012.</p></bio><bio xml:lang="ru"><p>410012 Саратов, ул. Большая Казачья, 112.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3463-7734</contrib-id><name-alternatives><name xml:lang="en"><surname>Rebrov</surname><given-names>A. P.</given-names></name><name xml:lang="ru"><surname>Ребров</surname><given-names>А. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>112 Bolshaya Kazachya St., Saratov  410012.</p></bio><bio xml:lang="ru"><p>410012 Саратов, ул. Большая Казачья, 112.</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">V.I. Razumovsky Saratov State Medical University, Health Ministry of Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Саратовский государственный медицинский университет им. В.И. Разумовского» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2023</year></pub-date><volume>17</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>28</fpage><lpage>38</lpage><history><date date-type="received" iso-8601-date="2023-10-21"><day>21</day><month>10</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-10-21"><day>21</day><month>10</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Grigoryeva E.V., Tyapkina D.A., Boroday A.A., Blokhin I.S., Kondrashkin I.E., Polidanov M.A., Rebrov A.P.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Григорьева Е.В., Тяпкина Д.А., Бородай А.А., Блохин И.С., Кондрашкин И.Е., Полиданов М.А., Ребров А.П.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Grigoryeva E.V., Tyapkina D.A., Boroday A.A., Blokhin I.S., Kondrashkin I.E., Polidanov M.A., Rebrov A.P.</copyright-holder><copyright-holder xml:lang="ru">Григорьева Е.В., Тяпкина Д.А., Бородай А.А., Блохин И.С., Кондрашкин И.Е., Полиданов М.А., Ребров А.П.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://klinitsist.abvpress.ru/Klin/article/view/549">https://klinitsist.abvpress.ru/Klin/article/view/549</self-uri><abstract xml:lang="en"><p><bold>Aim.</bold> To study the features of the course of COVID-19 in pregnant women, the outcomes of a new coronavirus infection and pregnancy, the effect of concomitant pathology on the severity of the course and the frequency of complications of COVID-19.</p><p><bold>Materials and methods.</bold> In the course of the work, a retrospective analysis of 109 medical histories of pregnant women who were treated in the infectious diseases department in 2021 with a diagnosis of COVID-19 was carried out. Anamnesis, concomitant pathology, results of objective examination, laboratory and instrumental methods of research, therapy, complications, outcomes of COVID-19 and pregnancy were evaluated.</p><p><bold>Results.</bold> The majority of pregnant women had moderate – 55 % and severe – 24 % COVID-19, 7 % – extremely severe and only 14 % – mild. A third of pregnant women had concomitant pathology, arterial hypertension was the most common; 80 % of pregnant women had complications of COVID-19: cytokine storm – in 50 % of patients, acute respiratory distress syndrome – in 17 %, of which 5 % required artificial lung ventilation. The mortality rate was 4.6 %. The structure of pregnancy complications was dominated by gestational hypertension, gestational diabetes, premature placental abruption, preeclampsia. Complications of childbirth – premature birth and premature discharge of amniotic fluid. However, in most cases, pregnancy (75 %) and childbirth (71 %) proceeded without complications. Women in 95 % of cases were discharged from the hospital with recovery or significant clinical improvement.</p><p><bold>Conclusion.</bold> Despite the prevalence of moderate and severe forms of COVID-19 in pregnant women, a high percentage of concomitant pathology and complications, in most cases favorable outcomes of both COVID-19 and pregnancy were noted. The presence of hypertension syndrome should probably be considered as a prognostically unfavorable marker of severe course and adverse outcomes of COVID-19 in pregnant women.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель исследования</bold> – изучение особенностей течения новой коронавирусной инфекции (COVID-19) у беременных, анализ исходов COVID-19 и беременности, влияния сопутствующей патологии на тяжесть течения и частоту развития осложнений COVID-19.</p><p><bold>Материалы и методы.</bold> Проведен ретроспективный анализ 109 историй болезни беременных, находившихся на лечении в 2021 г. в инфекционном отделении ГУЗ «Областная клиническая больница» (г. Саратов) с диагнозом COVID-19. Оценивались анамнез, сопутствующая патология, результаты объективного осмотра, лабораторных и инструментальных методов исследования, терапия, осложнения, исходы COVID-19 и беременности.</p><p><bold>Результаты.</bold> У большей части беременных отмечено среднетяжелое (у 55 % пациенток), тяжелое (у 24 %), крайне тяжелое (у 7 %) течение COVID-19 и только у 14 % женщин – легкое. У трети беременных выявлена сопутствующая патология. Наиболее часто встречалась артериальная гипертония. У 80 % беременных возникли осложнения COVID-19: цитокиновый шторм (у 50 %), острый респираторный дистресс-синдром (у 17 %), из них искусственная вентиляция легких потребовалась 5 %, летальность составила 4,6 %. В структуре осложнений беременности преобладали гестационная артериальная гипертензия, гестационный диабет, преждевременная отслойка плаценты, преэклампсия. Осложнениями родов были преждевременные роды и преждевременное излитие околоплодных вод. Однако в большинстве случаев беременность (75 %) и роды (71 %) протекали без осложнений. Женщины в 95 % случаев были выписаны из стационара с выздоровлением или значимым клиническим улучшением.</p><p><bold>Заключение.</bold> Несмотря на преобладание среднетяжелых и тяжелых форм COVID-19 у беременных, существенную долю сопутствующей патологии и осложнений, в большинстве случаев отмечены благоприятные исходы как COVID-19, так и беременности. Наличие синдрома артериальной гипертензии, возможно, следует рассматривать как прогностически неблагоприятный маркер тяжелого течения и неблагоприятных исходов COVID-19 у беременных.</p></trans-abstract><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>pregnancy</kwd><kwd>childbirth</kwd><kwd>concomitant diseases</kwd><kwd>hypertension</kwd><kwd>complications</kwd><kwd>cytokine storm</kwd><kwd>acute respiratory distress syndrome</kwd><kwd>preeclampsia</kwd><kwd>eclampsia</kwd><kwd>fatal outcome</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>беременность</kwd><kwd>роды</kwd><kwd>сопутствующие заболевания</kwd><kwd>артериальная гипертензия</kwd><kwd>осложнения</kwd><kwd>цитокиновый шторм</kwd><kwd>острый респираторный дистресс-синдром</kwd><kwd>преэклампсия</kwd><kwd>эклампсия</kwd><kwd>летальный исход</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Poorolajal J. 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