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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">The Clinician</journal-id><journal-title-group><journal-title xml:lang="en">The Clinician</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиницист</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8338</issn><issn publication-format="electronic">2412-8775</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">54</article-id><article-id pub-id-type="doi">10.17650/1818-8338-2012-3-4-44-48</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>LECTION</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Chronic pain syndrome: Pathogenesis, clinical presentation, treatment</article-title><trans-title-group xml:lang="ru"><trans-title>Хронический болевой синдром: особенности патогенеза, клиники, лечения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Suvorov</surname><given-names>A. Yu.</given-names></name><name xml:lang="ru"><surname>Суворов</surname><given-names>А. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nnexen@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">State Research Center of Preventive Medicine, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ ГНИЦПМ Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2012</year></pub-date><volume>6</volume><issue>3-4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>44</fpage><lpage>48</lpage><history><date date-type="received" iso-8601-date="2014-07-15"><day>15</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-15"><day>15</day><month>07</month><year>2014</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, Suvorov A.Y.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, Суворов А.Ю.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">Suvorov A.Y.</copyright-holder><copyright-holder xml:lang="ru">Суворов А.Ю.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://klinitsist.abvpress.ru/Klin/article/view/54">https://klinitsist.abvpress.ru/Klin/article/view/54</self-uri><abstract xml:lang="en"><p>The paper considers main ideas on the prevalence, course, and therapy of chronic pain syndrome. It describes its manifestations, different course variants, and approaches to treating the diseases accompanied by chronic pain. Different approaches to long-term therapy, which involve combination treatment options, are discussed. Data on the use of nonsteroidal antinflammatory drugs as the most common agents to relieve both acute and chronic pain syndrome are given in detail. The data of numerous trials evaluating both the analgesic and anti-inflammatory effects of nonsteroidal anti-inflammatory drugs are presented.</p></abstract><trans-abstract xml:lang="ru"><p>В статье рассматриваются основные представления о распространенности, течении и терапии хронического болевого синдрома. Освещены проявления хронического болевого синдрома в соответствии с локализацией поражения, различные варианты течения и подходы к лечению заболеваний, сопровождающихся хронической болью. Обсуждаются различные подходы к длительной терапии, включающие и комбинированные методы лечения. Широко представлены данные об использовании нестероидных противовоспалительных препаратов как самых распространенных средств для купирования как острого, так и хронического болевого синдрома. Представлены данные многочисленных исследований, оценивающие анальгетический и противовоспалительный эффекты нестероидных противовоспалительных препаратов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>pain syndrome</kwd><kwd>pain</kwd><kwd>nonsteroidal anti-inflammatory drugs</kwd><kwd>effectiveness of drugs</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>болевой синдром</kwd><kwd>боль</kwd><kwd>нестероидные противовоспалительные препараты</kwd><kwd>эффективность лекарственных препаратов</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Fernandez E., Vargas R., Mahometa M. et al. Descriptors of pain sensation: a dual hierarchical model of latent structure. J Pain 2012;13(6):532–6.</mixed-citation><mixed-citation xml:lang="ru">Fernandez E., Vargas R., Mahometa M. et al. Descriptors of pain sensation: a dual hierarchical model of latent structure. J Pain 2012;13(6):532–6.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Wall P.D. «Pain», the journal of the International Association for theStudy of Pain.Pain 1975;1(1):1–2.</mixed-citation><mixed-citation xml:lang="ru">Wall P.D. «Pain», the journal of the International Association for theStudy of Pain.Pain 1975;1(1):1–2.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Landmark T., Romundstad P., Dale O. et al. Estimating the prevalence of chronic pain: validation of recall against longitudinal reporting (the HUNT pain study). Pain 2012;153(7):1368–73.</mixed-citation><mixed-citation xml:lang="ru">Landmark T., Romundstad P., Dale O. et al. Estimating the prevalence of chronic pain: validation of recall against longitudinal reporting (the HUNT pain study). Pain 2012;153(7):1368–73.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Johannes C.B., Le T.K., Zhou X. et al. The prevalence of chronic pain in United States adults: results of an Internet-based survey. J Pain 2010;11(11):1230–9.</mixed-citation><mixed-citation xml:lang="ru">Johannes C.B., Le T.K., Zhou X. et al. The prevalence of chronic pain in United States adults: results of an Internet-based survey. J Pain 2010;11(11):1230–9.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Pergolizzi J. Chronic pain – moving from symptom control to mechanism-based treatment.</mixed-citation><mixed-citation xml:lang="ru">Pergolizzi J. Chronic pain – moving from symptom control to mechanism-based treatment.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><mixed-citation>Curr Med Res Opin 2011;27(10):2079–80.</mixed-citation></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">6. Melzack R. The McGill Pain Questionnaire: major properties and scoring methods. Pain 1975;1(3):277–99.</mixed-citation><mixed-citation xml:lang="ru">Melzack R. The McGill Pain Questionnaire: major properties and scoring methods. Pain 1975;1(3):277–99.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">7. Martel M.O., Thibault P., Sullivan M.J. Judgments about pain intensity and pain genuineness: the role of pain behavior and judgmental heuristics. J Pain 2011;12(4):468–75.</mixed-citation><mixed-citation xml:lang="ru">Martel M.O., Thibault P., Sullivan M.J. Judgments about pain intensity and pain genuineness: the role of pain behavior and judgmental heuristics. J Pain 2011;12(4):468–75.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">8. Fabbri E., Villa G., Mabrouk M. et al. McGill Pain Questionnaire: a multi-dimensional verbal scale assessing postoperative changes in pain symptoms associated with severe endometriosis. J Obstet Gynaecol Res 2009;35(4):753–60.</mixed-citation><mixed-citation xml:lang="ru">Fabbri E., Villa G., Mabrouk M. et al. McGill Pain Questionnaire: a multi-dimensional verbal scale assessing postoperative changes in pain symptoms associated with severe endometriosis. J Obstet Gynaecol Res 2009;35(4):753–60.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">9. Strassberg D.S., Reimherr F., Ward M. et al. The MMPI and chronic pain. J Consult Clin Psychol 1981;49(2):220–6.</mixed-citation><mixed-citation xml:lang="ru">Strassberg D.S., Reimherr F., Ward M. et al. The MMPI and chronic pain. J Consult Clin Psychol 1981;49(2):220–6.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">10. Шостак Н.А., Клименко А.А., Николенко М.В. Остеоартроз: вопросы патогенеза и лечение. Клиницист 2010;(1):47–53.</mixed-citation><mixed-citation xml:lang="ru">Шостак Н.А., Клименко А.А., Николенко М.В. Остеоартроз: вопросы патогенеза и лечение. Клиницист 2010;(1):47–53.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">11. Насонов Е.Л. Ревматология. Клинические рекомендации. М.: ГЭОТАР-Медиа, 2008. 282 с.</mixed-citation><mixed-citation xml:lang="ru">Насонов Е.Л. Ревматология. Клинические рекомендации. М.: ГЭОТАР-Медиа, 2008. 282 с.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">12. Aurora S.K., Kulthia A., Barrodale P.M. Mechanism of chronic migraine. Curr Pain Headache Rep 2011;15(1):57–63.</mixed-citation><mixed-citation xml:lang="ru">Aurora S.K., Kulthia A., Barrodale P.M. Mechanism of chronic migraine. Curr Pain Headache Rep 2011;15(1):57–63.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">13. Nett M.P. Postoperative pain management. Orthopedics 2010;33(9 Suppl):23–6.</mixed-citation><mixed-citation xml:lang="ru">Nett M.P. Postoperative pain management. Orthopedics 2010;33(9 Suppl):23–6.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">14. Benitez Del Rosario M.A., Perez Suarez M.C., Fernandez Diaz R., Cabrejas Sanchez A. Paliative treatment: Treatment of chronic cancer pain (ii): the use of opiates. Aten Primaria 2002;29(8):513–6.</mixed-citation><mixed-citation xml:lang="ru">Benitez Del Rosario M.A., Perez Suarez M.C., Fernandez Diaz R., Cabrejas Sanchez A. Paliative treatment: Treatment of chronic cancer pain (ii): the use of opiates. Aten Primaria 2002;29(8):513–6.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">15. Sullivan A.B., Scheman J., Venesy D., Davin S. The role of exercise and types of exercise in the rehabilitation of chronic pain: specific or nonspecific benefits. Curr Pain Headache Rep 2012;16(2):153–61.</mixed-citation><mixed-citation xml:lang="ru">Sullivan A.B., Scheman J., Venesy D., Davin S. The role of exercise and types of exercise in the rehabilitation of chronic pain: specific or nonspecific benefits. Curr Pain Headache Rep 2012;16(2):153–61.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">16. Paiotti A.P., Marchi P., Miszputen S.J. et al. The role of nonsteroidal antiinflammatory drugs and cyclooxygenase-2 inhibitors on experimental colitis. In Vivo 2012;26(3):381–93.</mixed-citation><mixed-citation xml:lang="ru">Paiotti A.P., Marchi P., Miszputen S.J. et al. The role of nonsteroidal antiinflammatory drugs and cyclooxygenase-2 inhibitors on experimental colitis. In Vivo 2012;26(3):381–93.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">17. Spickler W. Ketorolac (Toradol): a new analgesic or an old NSAID? CMAJ 1993;148(10):1693–5.</mixed-citation><mixed-citation xml:lang="ru">Spickler W. Ketorolac (Toradol): a new analgesic or an old NSAID? CMAJ 1993;148(10):1693–5.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">18. Gillies G.W., Kenny G.N., Bullingham R.E., McArdle C.S. The morphine sparing effect of ketorolac</mixed-citation><mixed-citation xml:lang="ru">Gillies G.W., Kenny G.N., Bullingham R.E., McArdle C.S. The morphine sparing effect of ketorolac</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><mixed-citation>tromethamine. A study of a new, parenteral non-steroidal anti-inflammatory agent after abdominal surgery. Anaesthesia 1987;42(7):727–31.</mixed-citation></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">19. Suhail M.S., Christianson C., Kohern F. et al. Effects of long term polyarthritis and subsequent NSAID treatment on activity with disassociation of tactile allodynia in the mouse. Neurocomputing 2012;84:47–52.</mixed-citation><mixed-citation xml:lang="ru">Suhail M.S., Christianson C., Kohern F. et al. Effects of long term polyarthritis and subsequent NSAID treatment on activity with disassociation of tactile allodynia in the mouse. Neurocomputing 2012;84:47–52.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">20. Kelley N.E., Tepper D.E. Rescue therapy for acute migraine, part 3: opioids, NSAIDs, steroids, and post-discharge medications. Headache 2012;52(3):467–82.</mixed-citation><mixed-citation xml:lang="ru">Kelley N.E., Tepper D.E. Rescue therapy for acute migraine, part 3: opioids, NSAIDs, steroids, and post-discharge medications. Headache 2012;52(3):467–82.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">21. Mattia C., Ciarcia S., Muhindo A., Coluzzi F. Nimesulide: 25 years later. Minerva</mixed-citation><mixed-citation xml:lang="ru">Mattia C., Ciarcia S., Muhindo A., Coluzzi F. Nimesulide: 25 years later. Minerva</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><mixed-citation>Med 2010;101(4):285–93.</mixed-citation></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">22. Clauw D., McCarberg B.H. Managing chronic pain with nonopioid analgesics: a multidisciplinary consult. Am J Med 2012;125(5):S1.</mixed-citation><mixed-citation xml:lang="ru">Clauw D., McCarberg B.H. Managing chronic pain with nonopioid analgesics: a multidisciplinary consult. Am J Med 2012;125(5):S1.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">23. Hashizume K. Diagnosis and treatment of chronic pain by pain clinician. Brain and nerve. Brain Nerve 2012;64(11):1315–22.</mixed-citation><mixed-citation xml:lang="ru">Hashizume K. Diagnosis and treatment of chronic pain by pain clinician. Brain and nerve. Brain Nerve 2012;64(11):1315–22.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
