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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">The Clinician</journal-id><journal-title-group><journal-title xml:lang="en">The Clinician</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиницист</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8338</issn><issn publication-format="electronic">2412-8775</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">524</article-id><article-id pub-id-type="doi">10.17650/1818-8338-2023-17-1-K678</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>EDITORIAL</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>РЕДАКЦИОННАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Acute rheumatic fever and rheumatic heart disease: what's new?</article-title><trans-title-group xml:lang="ru"><trans-title>Острая ревматическая лихорадка и ревматическая болезнь сердца: что нового?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8266-6022</contrib-id><name-alternatives><name xml:lang="en"><surname>Andriyashkina</surname><given-names>D. Yu.</given-names></name><name xml:lang="ru"><surname>Андрияшкина</surname><given-names>Д. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Daria Yurievna Andriyashkina </p><p>Acad. A. I. Nesterov of Faculty Therapy</p><p>1 Ostrovityanova St., Moscow 117997</p></bio><bio xml:lang="ru"><p>Дарья Юрьевна Андрияшкина </p><p>Кафедра факультетской терапии им. акад. А.И. Нестерова</p><p>117997 Москва, ул. Островитянова, 1</p></bio><email>andryashkina.darya@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4669-1006</contrib-id><name-alternatives><name xml:lang="en"><surname>Shostak</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Шостак</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A. I. Nesterov of Faculty Therapy</p><p>1 Ostrovityanova St., Moscow 117997</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А.И. Нестерова</p><p>117997 Москва, ул. Островитянова, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4259-3807</contrib-id><name-alternatives><name xml:lang="en"><surname>Aksenova</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Аксенова</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A. I. Nesterov of Faculty Therapy</p><p>1 Ostrovityanova St., Moscow 117997</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А.И. Нестерова</p><p>117997 Москва, ул. Островитянова, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4074-1300</contrib-id><name-alternatives><name xml:lang="en"><surname>Abeldyaev</surname><given-names>D. V.</given-names></name><name xml:lang="ru"><surname>Абельдяев</surname><given-names>Д. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A. I. Nesterov of Faculty Therapy</p><p>1 Ostrovityanova St., Moscow 117997</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А.И. Нестерова</p><p>117997 Москва, ул. Островитянова, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2023</year></pub-date><volume>17</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>12</fpage><lpage>20</lpage><history><date date-type="received" iso-8601-date="2023-08-10"><day>10</day><month>08</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-08-10"><day>10</day><month>08</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Andriyashkina D.Y., Shostak N.A., Aksenova A.V., Abeldyaev D.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Андрияшкина Д.Ю., Шостак Н.А., Аксенова А.В., Абельдяев Д.В.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Andriyashkina D.Y., Shostak N.A., Aksenova A.V., Abeldyaev D.V.</copyright-holder><copyright-holder xml:lang="ru">Андрияшкина Д.Ю., Шостак Н.А., Аксенова А.В., Абельдяев Д.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://klinitsist.abvpress.ru/Klin/article/view/524">https://klinitsist.abvpress.ru/Klin/article/view/524</self-uri><abstract xml:lang="en"><p>Rheumatic heart disease (RHD) is a preventable heart disease that remains endemic in developing countries. More than 30 million people in the world suffer from RHD, of which approximately 300,000 die every year, despite the fact that this disease is preventable and treatable. After a period of relative neglect of rheumatic heart diseases due to a decrease in the incidence in developed countries, interest in this problem has increased again over the past decade, due, apparent­ly, to an underestimation of its true prevalence due to the subclinical course of carditis. Research over the past two decades has demonstrated the advantage of diagnosing RHD with echocardiographic screening based on World Heart Federation echocardiographic criteria, which is 10 times greater than the clinical auscultatory picture only and it allowsearly detection of it in patients, while prevention is to be more likely to be effective. Although understanding of the pathogenesis of the disease has advanced in recent years, key issues remain unresolved. Preventing or providing early treatment for streptococcal infections is the most important step in reducing the burden of this disease. The manage­ment of women with rheumatic heart disease before, during and after pregnancy remains a serious task requiring the efforts of a multidisciplinary team. In 2015, a civil society movement was launched aimed at raising awareness and supporting countries seeking to solve the RHD problem. In May 2018, the World Health Organization adopted a resolu­tion aimed at intensifying global and national efforts to prevent and combat acute rheumatic fever/RHD. Ultimately, a combination of treatment options, research and advocacy based on existing knowledge and science provides the best opportunity to cope with the burden of rheumatic heart disease. The article summarizes the latest achievements in the science of RHD and presents priorities for current actions and future research.</p></abstract><trans-abstract xml:lang="ru"><p>Ревматическая болезнь сердца (РбС) – это предотвратимое заболевание сердца, которое остается эндемичным в развивающихся странах. более 30 млн человек в мире страдают РбС, из которых примерно 300 тыс. умирают каждый год, несмотря на то что это заболевание поддается профилактике и лечению. после периода относительного игнорирования ревматических болезней сердца в связи со снижением заболеваемости в развитых странах в последнее десятилетие во всем мире вновь возрос интерес к этой проблеме, обусловленный, по-видимому, недооценкой ее истинной распространенности в связи с субклиническим течением кардита. Исследования последних 2 десятилетий продемонстрировали преимущество диагностики РбС с помощью эхокардиографического скрининга, который основан на эхокардиографических критериях Всемирной федерации сердца и в 10 раз превышает только клиническую аускультативную картину. Это позволяет выявить заболевание на более раннем этапе, когда профилактика, скорее всего, будет эффективной. Хотя в последние годы понимание патогенеза заболевания продвинулось вперед, ключевые вопросы остаются нерешенными. профилактика или обеспечение раннего лечения стрептококковых инфекций – наиболее важный шаг в снижении бремени этого заболевания. Ведение женщин с ревматическим заболеванием сердца до, во время и после беременности остается серьезной задачей и требует усилий многопрофильной команды. В 2015 г. запущено движение гражданского общества по повышению осведомленности и поддержки стран, стремящихся решить проблему РбС. В мае 2018 г. Всемирная организация здравоохранения приняла резолюцию, направленную на активизацию глобальных и национальных усилий по профилактике ОРЛ / РбС и борьбе с ними. В конечном счете сочетание вариантов лечения, исследований и информационно-пропагандистской деятельности, основанной на существующих знаниях и науке, предоставляет наилучшую возможность справиться с бременем ревматических заболеваний сердца. В статье обобщены последние достижения в лечении РбС и представлены приоритеты для текущих действий и будущих исследований.</p></trans-abstract><kwd-group xml:lang="en"><kwd>acute rheumatic fever</kwd><kwd>rheumatic heart disease</kwd><kwd>subclinical carditis</kwd><kwd>valvulitis</kwd><kwd>mitral regurgitation</kwd><kwd>aortic regurgitation</kwd><kwd>echocardiography</kwd><kwd>pregnancy</kwd><kwd>vaccine</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>острая ревматическая лихорадка</kwd><kwd>ревматическая болезнь сердца</kwd><kwd>ревматический порок сердца</kwd><kwd>субклинический кардит</kwd><kwd>вальвулит</kwd><kwd>митральная регургитация</kwd><kwd>аортальная регургитация</kwd><kwd>эхокардиография</kwd><kwd>беременность</kwd><kwd>вакцина</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Watkins D.A., Johnson C.O., Colquhoun S.M. et al. Global, Regional, and National Burden of Rheumatic Heart Disease, 1990-2015. N Engl J Med 2017;377(8):713-22. DOI: 10.1056/NEJMoa1603693</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Meira Z.M., Goulart E.M., Colosimo E.A., Mota C.C. Long term follow up of rheumatic fever and predictors of severe rheumatic valvar disease in Brazilian children and adolescents. Heart 2005;91(8):1019-22. DOI: 10.1136/hrt.2004.042762</mixed-citation></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Longo-Mbenza B., Bayekula M., Ngiyulu R. et al. Survey of rheu¬matic heart disease in school children of Kinshasa town. Int J Car¬diol 1998;63(3):287-94. DOI: 10.1016/s0167-5273(97)00311-2</mixed-citation><mixed-citation xml:lang="ru">Longo-Mbenza B., Bayekula M., Ngiyulu R. et al. Survey of rheumatic heart disease in school children of Kinshasa town. Int J Cardiol 1998;63(3):287-94. DOI: 10.1016/s0167-5273(97)00311-2</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><mixed-citation>Watkins D.A., Beaton A.Z., Carapetis J.R. et al. Rheumatic Heart Disease Worldwide: JACC Scientific Expert Panel. J Am Coll Cardiol 2018;72(12):1397-416. DOI: 10.1016/j.jacc.2018.06.063</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Doukky R., Abusin S.A., Bayissa Y.A. et al. Rheumatic heart disease in modern urban America: a cohort study of immigrant and indigenous patients in Chicago. Int J Cardiol 2014;175(1):178-80. DOI: 10.1016/j.ijcard.2014.04.207</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Rothenbuhler M., O'Sullivan C.J., Stortecky S. et al. Active surveillance for rheumatic heart disease in endemic regions: a systematic review and meta-analysis of prevalence among children and adolescents. Lancet Glob Health 2014;2(12):e717-26. DOI: 10.1016/S2214-109X(14)70310-9</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Carapetis J.R., Zuhlke L.J. Global research priorities in rheumatic fever and rheumatic heart disease. Ann Pediatr Cardiol 2011;4(1):4-12. DOI: 10.4103/0974-2069.79616</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Gordis L. The virtual disappearance of rheumatic fever in the United States: lessons in the rise and fall of disease. T. Duckett Jones memorial lecture. Circulation 1985;72(6):1155-62. DOI: 10.1161/01.cir.72.6.1155</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Massell B.F., Chute C.G., Walker A.M., Kurland G.S. Penicillin and the marked decrease in morbidity and mortality from rheumatic fever in the United States. N Engl J Med 1988;318(5):280-6. DOI: 10.1056/NEJM198802043180504</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>EXPERT committee on rheumatic diseases; first report. World Health Organ Tech Rep Ser 1954;78:1-25. PMID: 13157434</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Bach J.F., Chalons S., Forier E. et al. 10-year educational programme aimed at rheumatic fever in two French Caribbean islands. Lancet 1996;347(9002):644-8. DOI: 10.1016/s0140-6736(96)91202-7</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Nordet P., Lopez R., Duenas A., Sarmiento L. Prevention and control of rheumatic fever and rheumatic heart disease: the Cuban experience (1986-1996-2002). Cardiovasc J Afr 2008;19(3): 135-40. PMID: 18568172</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Gunther G., Asmera J., Parry E. Death from rheumatic heart disease in rural Ethiopia. Lancet 2006;367(9508):391. DOI: 10.1016/S0140-6736(06)68128-2</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Colquhoun S.M., Condon J.R., Steer A.C. et al. Disparity in mortality from rheumatic heart disease in indigenous Australians. J Am Heart Assoc 2015;4(7):e001282. DOI: 10.1161/JAHA.114.001282</mixed-citation></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Parks T., Kado J., Miller A.E. et al. Rheumatic heart disease- attributable mortality at ages 5-69 years in Fiji: a five-year, national, population-based record-linkage cohort study. PloS Negl Trop Dis 2015;9(9):e0004033. DOI: 10.1371/journal.pntd.0004033</mixed-citation><mixed-citation xml:lang="ru">Parks T., Kado J., Miller A.E. et al. Rheumatic heart disease-attributable mortality at ages 5-69 years in Fiji: a five-year, national, population-based record-linkage cohort study. PloS Negl Trop Dis 2015;9(9):e0004033. DOI: 10.1371/journal.pntd.0004033</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><mixed-citation>Maurice J. Rheumatic heart disease back in the limelight. Lancet 2013;382(9898):1085-6. DOI: 10.1016/s0140-6736(13)61972-8</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Marijon E., Ou P., Celermajer D.S. et al. Prevalence of rheumatic heart disease detected by echocardiographic screening. N Engl J Med 2007;357(5):470-6. DOI: 10.1056/NEJMoa065085</mixed-citation></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">Global action plan for the prevention and control of noncom-municable diseases 2013-2020. Geneva: World Health Organization, 2013. Available at: https://apps.who.int&gt;iris/handle/10665/94384</mixed-citation><mixed-citation xml:lang="ru">Global action plan for the prevention and control of noncommunicable diseases 2013-2020. Geneva: World Health Organization, 2013. Available at: https://apps.who.int&gt;iris/handle/10665/94384</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><mixed-citation>Remenyi B., Carapetis J., Wyber R. et al. Position statement of the World Heart Federation on the prevention and control of rheumatic heart disease. Nat Rev Cardiol 2013;5(10):284-92. DOI: 10.1038/nrcardio.2013.34</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Francis J.R., Gargan C., Remenyi B. et al. A cluster of acute rheumatic fever cases among Aboriginal Australians in a remote community with high baseline incidence. Aust NZJ Public Health 2019;43(3):288-93. DOI: 10.1111/1753-6405.12893</mixed-citation></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">Pastore S., De Cunto A., Benettoni A. et al. The resurgence of rheumatic fever in a developed country area: the role of echo-cardiography. Rheumatology (Oxford) 2011;50(2):396-400. DOI: 10.1093/rheumatology/keq290</mixed-citation><mixed-citation xml:lang="ru">Pastore S., De Cunto A., Benettoni A. et al. The resurgence of rheumatic fever in a developed country area: the role of echocardiography. Rheumatology (Oxford) 2011;50(2):396-400. DOI: 10.1093/rheumatology/keq290</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><mixed-citation>Veasy L.G., Wiedmeier S.E., Orsmond G.S. et al. Resurgence of acute rheumatic fever in the intermountain area of the United States. N Engl J Med 1987;316(4):421-7. DOI: 10.1056/NEJM198702193160801</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Kumar R.K., Tandon R. Rheumatic fever &amp; rheumatic heart disease: the last 50 years. Indian J Med Res 2013;137(4):643-58. PMID: 23703332</mixed-citation></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">Kuzmina N.N., Medyntseva L.G., Belov B.S. Rheumatic fever: Semicentennial experience in studying the problem. Razmy'shleniya revmatologa. Nauchno-prakticheskaya revmatologiya = Reflections of a rheumatologist. Rheumatology Science and Practice 2017;55(2):125-37 (In Russ.). DOI: 10.14412/1995-4484-2017-125-137</mixed-citation><mixed-citation xml:lang="ru">Кузьмина Н.Н., Медынцева Л.Г., Белов Б.С. Ревматическая лихорадка: полувековой опыт изучения проблемы. Размышления ревматолога. Научно-практическая ревматология 2017;55(2):125-37. DOI: 10.14412/1995-4484-2017-125-137</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">Morbidity of the population of Russia in 2014. Statistical materials. Moscow, 2015. </mixed-citation><mixed-citation xml:lang="ru">Заболеваемость населения России в 2014 г. Статистические материалы. М., 2015.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">Aksenova A.V., Abeldyaev D.V., Glushkova E.V. Current epidemiological aspects of streptococcal and post-streptococcal diseases in the Russian Federation. Klinitsist = The Clinician 2020;14(1-2):14-23. (In Russ.). DOI: 10.17650/1818-8338-2020¬14-1-2-14-23</mixed-citation><mixed-citation xml:lang="ru">Аксенова А.В., Абельдяев Д.В., Глушкова Е.В. Эпидемиологические аспекты стрептококковых и постстрептококковых заболеваний в Российской Федерации на современном этапе. Клиницист 2020;14(1-2):14-23. DOI: 10.17650/1818-83382020-14-1-2-14-23</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">Gewitz M.H., Baltimore R.S., Tani L.Y. et al. Revision of the Jones criteria for the diagnosis of acute rheumatic fever in the era of doppler echocardiography: a scientific statement from the American Heart Association. Circulation 2015;131(20):1806- 18. DOI: 10.1161/CIR.0000000000000205</mixed-citation><mixed-citation xml:lang="ru">Gewitz M.H., Baltimore R.S., Tani L.Y. et al. Revision of the Jones criteria for the diagnosis of acute rheumatic fever in the era of doppler echocardiography: a scientific statement from the American Heart Association. Circulation 2015;131(20):1806-18. DOI: 10.1161/CIR.0000000000000205</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><mixed-citation>Rheumatic fever and rheumatic heart disease: report of a WHO Expert Consultation, Geneva, 29 October - 1 November 2001. Geneva: World Health Organization, 2004. Available at: https://apps.who.int/iris/handle/10665/42898</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Tubridy-Clark M., Carapetis J.R. Subclinical carditis in rheumatic fever: a systematic review. Int J Cardiol 2007;119(1):54-8. DOI: 10.1016/j.ijcard.2006.07.046.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Zuhlke L., Engel M.E., Karthikeyan G. et al. Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart Disease Registry (the REMEDY study). Eur Heart J 2015;36(18):1115-22a. DOI: 10.1093/eurheartj/ehu449</mixed-citation></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">Wilson N.J., Voss L., Morreau J. et al. New Zealand guidelines for the diagnosis of acute rheumatic fever: small increase in the inci-dence of definite cases compared to the America Heart Association Jones criteria. N Z Med J 2013;126(1379):50-9. PMID: 24045352</mixed-citation><mixed-citation xml:lang="ru">Wilson N.J., Voss L., Morreau J. et al. New Zealand guidelines for the diagnosis of acute rheumatic fever: small increase in the incidence of definite cases compared to the America Heart Association Jones criteria. N Z Med J 2013;126(1379):50-9. PMID: 24045352</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><mixed-citation>Remenyi B., Wilson N., Steer A. et al. World Heart Federation criteria for echocardiographic diagnosis of rheumatic heart disease: an evidence-based guideline. Nat Rev Cardiol 2012;9(5):297-309. DOI: 10.1038/nrcardio.2012.7</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Watkins D., Beaton A. Carapetis J.R. et al. Rheumatic Heart Disease Worldwide: JACC Scientific Expert Panel. J Am Coll Cardiol 2018;72(12):1397-416. DOI: 10.1016/j.jacc.2018.06.063</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Abernethy M., Bass N., Sharpe N. et al. Doppler echocardiography and the early diagnosis of carditis in acute rheumatic fever. Aust N Z J Med 1994;24(5):530-5. DOI: 10.1111/j.1445-5994.1994.tb01753.x</mixed-citation></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">Minich L.L., Tani L.Y., Pagotto L.T. et al. Doppler echocardio¬graphy distinguishes between physiologic and pathologic “silent” mitral regurgitation in patients with rheumatic fever. Clin Cardiol 1997;20(11):924-6. DOI: 10.1002/clc.4960201105</mixed-citation><mixed-citation xml:lang="ru">Minich L.L., Tani L.Y., Pagotto L.T. et al. Doppler echocardiography distinguishes between physiologic and pathologic “silent” mitral regurgitation in patients with rheumatic fever. Clin Cardiol 1997;20(11):924-6. DOI: 10.1002/clc.4960201105</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><mixed-citation>World Health Organization. WHA71.14: Rheumatic Fever and Rheumatic Heart Disease. 2018. Available at: https://apps.who.int/gb/ebwha/pdf_files/WHA71/A71_R14-en.pdf</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Watkins D.A., Sebitloane M., Engel M.E., Mayosi B.M. The burden of antenatal heart disease in South Africa: a systematic review. BMC Cardiovasc Disord 2012;12:23. DOI: 10.1186/1471-2261-12-23</mixed-citation></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">Anthony J., Osman A., Sani M.U. Valvular heart disease in pre¬gnancy. Cardiovasc J Afr 2016;27(2):111-8. DOI: 10.5830/CVJA-2016-052</mixed-citation><mixed-citation xml:lang="ru">Anthony J., Osman A., Sani M.U. Valvular heart disease in pregnancy. Cardiovasc J Afr 2016;27(2):111-8. DOI: 10.5830/CVJA-2016-052</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><mixed-citation>van Hagen I.M., Thorne S.A., Taha N. et al. Pregnancy outcomes in women with rheumatic mitral valve disease: results from the Registry of Pregnancy and Cardiac Disease. Circulation 2018;137(8):806-16. DOI: 10.1161/CIRCULATIONAHA.117.032561</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Rezk M., Elkilani O., Shaheen A. et al. Maternal hemodynamic changes and predictors of poor obstetric outcome in women with rheumatic heart disease: a five-year observational study. J Matern Fetal Neonatal Med 2018:131(12):1542-7. DOI: 10.1080/14767058.2017.1319932</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Diao M., Kane A., Ndiaye M.B. et al. Pregnancy in women with heart disease in sub-Saharan Africa. Arch Cardiovasc Dis 2011;104(6-7):370-4. DOI: 10.1016/j.acvd.2011.04.001</mixed-citation></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">Otto H., Saether S.G., Banteyrga L. et al. High prevalence of sub- clinical rheumatic heart disease in pregnant women in a developing country: an echocardiographic study. Echocardiography 2011;28(10):1049-53. DOI: 10.1111/j.1540-8175.2011.01520.x</mixed-citation><mixed-citation xml:lang="ru">Otto H., Saether S.G., Banteyrga L. et al. High prevalence of sub-clinical rheumatic heart disease in pregnant women in a developing country: an echocardiographic study. Echocardiography 2011;28(10):1049-53. DOI: 10.1111/j.1540-8175.2011.01520.x</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><mixed-citation>D'Souza R., Ostro J., Shah P.S. et al. Anticoagulation for pregnant women with mechanical heart valves: a systematic review and meta-analysis. Eur Heart J 2017;389190:1509-16. DOI: 10.1093/eurheartj/ehx032</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Xu Z., Fan J., Luo X. et al. Anticoagulation regimens during pregnancy in patients with mechanical heart valves: a systematic review and meta-analysis. Can J Cardiol 2016;32(10):1248.e1-9. DOI: 10.1016/j.cjca.2015.11.005</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>French K.A., Poppas A. Rheumatic heart disease in pregnancy: global challenges and clear opportunities. Circulation 2018;137(8): 817-9. DOI: 10.1161/CIRCULATIONAHA.118.033465</mixed-citation></ref></ref-list></back></article>
