The ClinicianThe ClinicianКлиницист1818-83382412-8775Publishing House ABV Press5110.17650/1818-8338-2012-3-4-28-32ORIGINAL INVESTIGATIONSОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕDiagnostic value of placental growth factor in patients with coronary heart diseaseДиагностическое значение плацентарного фактора роста у больных ишемической болезнью сердцаTulikovM. V.ТуликовМ. В.
Russian Federation
ShevchenkoO. P.ШевченкоО. П.
Russian Federation

Department of Cardiology

Кафедра кардиологии факультета усовершенствования врачей

ShevchenkoA. O.ШевченкоА. О.
Russian Federation

Department of Cardiology

Кафедра кардиологии факультета усовершенствования врачей

ShinYe. V.ШинЕ. В.
Russian Federation
GagayevA. V.ГагаевА. В.
Russian Federation
PavlovV. V.ПавловВ. В.
Russian Federation
Clinical Hospital, Department for Presidential Affairs of the Russian FederationФГБУ «Клиническая больница» Управления делами Президента Российской ФедерацииFaculty for Postgraduate Training of Physicians, N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России1510201263-428321507201415072014Copyright ©; 2012, Tulikov M.V., Shevchenko O.P., Shevchenko A.O., Shin Y.V., Gagayev A.V., Pavlov V.V.Copyright ©; 2012, Туликов М.В., Шевченко О.П., Шевченко А.О., Шин Е.В., Гагаев А.В., Павлов В.В.2012Tulikov M.V., Shevchenko O.P., Shevchenko A.O., Shin Y.V., Gagayev A.V., Pavlov V.V.Туликов М.В., Шевченко О.П., Шевченко А.О., Шин Е.В., Гагаев А.В., Павлов В.В.https://creativecommons.org/licenses/by/4.0https://klinitsist.abvpress.ru/Klin/article/view/51

Objective: to study the diagnostic value of placental growth factor (PlGF) in patients with coronary heart disease (CHD). 

Subjects and methods. 151 patients (75 men and 76 women; mean age 58.9 ± 12.3 years), including 66 patients with exercise-induced stable angina, 32 with unstable angina, 32 with myocardial infarction, and 21 with no clinical signs of CHD), were followed up. Blood PlGF levels were measured in all the examinees; C-reactive protein (CRP) concentrations were also determined using a high-sensitivity method in the patients with CHD.

Results. In the patients with acute coronary syndrome (ACS), the levels of PlGF were significantly higher than in those with exercise-induced stable angina and in healthy individuals (17.3 ± 11.4 versus 11.2 ± 7.3 and 8.8 ± 6.7 pg/ml; p < 0.001). Estimation of the diagnostic value of the determination of PlGF levels in the diagnosis of ACS in troponin-negative examinees revealed that the area under the ROC curve (AUC) was 0.76. The quality of a diagnostic model using CRP was inferior to that with PlGF (n = 45; AUC for PlGF = 0.79; that for CRP = 0.65).

Conclusion. The elevated level of PlGF may be considered as a diagnostic marker for ACS, including in the absence of the higher levels of cardiac troponins.

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