<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">The Clinician</journal-id><journal-title-group><journal-title xml:lang="en">The Clinician</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиницист</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8338</issn><issn publication-format="electronic">2412-8775</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">43</article-id><article-id pub-id-type="doi">10.17650/1818-8338-2013-1-55-59</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CASE REPORT</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОПИСАНИЕ СЛУЧАЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">A CASE OF OSTEOPOROSIS OF THE SPINE IN AN ELDERLY MALE WITH CALCIFIC AORTIC STENOSIS</article-title><trans-title-group xml:lang="ru"><trans-title>СЛУЧАЙ ОСТЕОПОРОЗА ПОЗВОНОЧНИКА У МУЖЧИНЫ С КАЛЬЦИНИРОВАННЫМ АОРТАЛЬНЫМ СТЕНОЗОМ В ПОЖИЛОМ ВОЗРАСТЕ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Karpova</surname><given-names>N. Yu.</given-names></name><name xml:lang="ru"><surname>Карпова</surname><given-names>Н. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shostak</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Шостак</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rashid</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Рашид</surname><given-names>М. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>miran68@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sorokoletov</surname><given-names>S. M.</given-names></name><name xml:lang="ru"><surname>Сороколетов</surname><given-names>С. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kazakova</surname><given-names>T. V.</given-names></name><name xml:lang="ru"><surname>Казакова</surname><given-names>Т. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">City Clinical Hospital Fifty-Five, Moscow Healthcare Department</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Городская клиническая больница № 55» Департамента здравоохранения г. Москвы</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2013</year></pub-date><volume>7</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>55</fpage><lpage>59</lpage><history><date date-type="received" iso-8601-date="2014-07-15"><day>15</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-15"><day>15</day><month>07</month><year>2014</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Karpova N.Y., Shostak N.A., Rashid M.A., Sorokoletov S.M., Kazakova T.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, Карпова Н.Ю., Шостак Н.А., Рашид М.А., Сороколетов С.М., Казакова Т.В.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Karpova N.Y., Shostak N.A., Rashid M.A., Sorokoletov S.M., Kazakova T.V.</copyright-holder><copyright-holder xml:lang="ru">Карпова Н.Ю., Шостак Н.А., Рашид М.А., Сороколетов С.М., Казакова Т.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://klinitsist.abvpress.ru/Klin/article/view/43">https://klinitsist.abvpress.ru/Klin/article/view/43</self-uri><abstract xml:lang="en"><p>The given clinical example presents a case of concomitant diseases of the heart and axial skeleton. Calcific aortic stenosis detected by chance in an elderly male was associated with osteoporosis of the lumbar spine with moderate perturbation of the calcium–vitamin D–parathyroid hormone axis and with no classical risk factors for impaired bone mineral density. Possible approaches to pathogenetic therapy are described.</p></abstract><trans-abstract xml:lang="ru"><p>В представленном клиническом примере описан случай сочетания заболеваний сердца и осевого скелета. Кальцинированный аортальный стеноз, выявленный случайно у мужчины пожилого возраста, сочетался с остеопорозом поясничного отдела позвоночника при умеренном нарушении оси кальций–витамин D–паратиреоидный гормон и в отсутствие классических факторов риска нарушений минеральной плотности костной ткани. Описаны возможные подходы к патогенетической терапии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>calcific aortic stenosis</kwd><kwd>osteoporosis</kwd><kwd>bisphosphonates</kwd><kwd>vitamin D preparations</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>кальцинированный аортальный стеноз</kwd><kwd>остеопороз</kwd><kwd>бисфосфонаты</kwd><kwd>препараты витамина D</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Wasilewski J., Mirota K., Wilczek K. et al. Calcific aortic valve damage as a risk factor for cardiovascular events. Pol J Radiol 2012;77(4):30–4.</mixed-citation><mixed-citation xml:lang="ru">Wasilewski J., Mirota K., Wilczek K. et al. Calcific aortic valve damage as a risk factor for cardiovascular events. Pol J Radiol 2012;77(4):30–4.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Goldstein R.E. Bone modifiers and the quest to slow progression of aortic stenosis. Am J Cardiol 2009;104(1):125–7.</mixed-citation><mixed-citation xml:lang="ru">Goldstein R.E. Bone modifiers and the quest to slow progression of aortic stenosis. Am J Cardiol 2009;104(1):125–7.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Skolnick A.H., Osranek M., Formica P., Kronzon I. Osteoporosis treatment and progression of aortic stenosis. Am J Cardiol 2009;104(1):122–4.</mixed-citation><mixed-citation xml:lang="ru">Skolnick A.H., Osranek M., Formica P., Kronzon I. Osteoporosis treatment and progression of aortic stenosis. Am J Cardiol 2009;104(1):122–4.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Dweck M.R., Newby D.E. Osteoporosis is a major confounder in observational studies investigating bisphosphonate therapy in aortic stenosis. J Am Coll Cardiol 2012;60(11):1027–30.</mixed-citation><mixed-citation xml:lang="ru">Dweck M.R., Newby D.E. Osteoporosis is a major confounder in observational studies investigating bisphosphonate therapy in aortic stenosis. J Am Coll Cardiol 2012;60(11):1027–30.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. van Geldorp M.W., Heuvelman H.J., Kappetein A.P. et al. Quality of life among patients with severe aortic stenosis. Neth Heart J 2013;21(1):21–7.</mixed-citation><mixed-citation xml:lang="ru">van Geldorp M.W., Heuvelman H.J., Kappetein A.P. et al. Quality of life among patients with severe aortic stenosis. Neth Heart J 2013;21(1):21–7.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Rajani R., Hancock J., Chambers J.B. The art of assessing aortic stenosis. Heart 2012;98(Suppl 4):iv14–22.</mixed-citation><mixed-citation xml:lang="ru">Rajani R., Hancock J., Chambers J.B. The art of assessing aortic stenosis. Heart 2012;98(Suppl 4):iv14–22.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Williamson M.A., Gelfand E.V. Care of patients with apparently asymptomatic severe aortic valve stenosis. Clin Cardiol 2012;35(12):E29–34.</mixed-citation><mixed-citation xml:lang="ru">Williamson M.A., Gelfand E.V. Care of patients with apparently asymptomatic severe aortic valve stenosis. Clin Cardiol 2012;35(12):E29–34.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Шостак Н.А., Карпова Н.Ю., Раши д М.А. Кальцинированный аортальный стеноз – принципы диагностики и лечения. Науч-практ ревматол 2005;(5):68–75.</mixed-citation><mixed-citation xml:lang="ru">Шостак Н.А., Карпова Н.Ю., Раши д М.А. Кальцинированный аортальный стеноз – принципы диагностики и лечения. Науч-практ ревматол 2005;(5):68–75.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Bhattacharyya S., Hayward C., Pepper J., Senior R. Risk stratification in asymptomatic severe aortic stenosis: a critical appraisal. Eur Heart J 2012;33(19):2377–87.</mixed-citation><mixed-citation xml:lang="ru">Bhattacharyya S., Hayward C., Pepper J., Senior R. Risk stratification in asymptomatic severe aortic stenosis: a critical appraisal. Eur Heart J 2012;33(19):2377–87.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Elder D.H., McAlpine-Scott V., Choy A.M. et al. Aortic valvular heart disease: is there a place for angiotensinconvertingenzyme inhibitors? Expert Rev Cardiovasc Ther 2013;11(1):107–14.</mixed-citation><mixed-citation xml:lang="ru">Elder D.H., McAlpine-Scott V., Choy A.M. et al. Aortic valvular heart disease: is there a place for angiotensinconvertingenzyme inhibitors? Expert Rev Cardiovasc Ther 2013;11(1):107–14.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Antoniou C.K., Chrysohoou C., Brili S. et al. Novel indices in calcific aortic valve stenosis. Hellenic J Cardiol 2012;53(4):310–7.</mixed-citation><mixed-citation xml:lang="ru">Antoniou C.K., Chrysohoou C., Brili S. et al. Novel indices in calcific aortic valve stenosis. Hellenic J Cardiol 2012;53(4):310–7.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Pibarot P., Dumesnil J.G. Improving assessment of aortic stenosis. J Am Coll Cardiol 2012;60(3):169–80.</mixed-citation><mixed-citation xml:lang="ru">Pibarot P., Dumesnil J.G. Improving assessment of aortic stenosis. J Am Coll Cardiol 2012;60(3):169–80.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Heuvelman H.J., van Geldorp M.W., Eijkemans M.J. et al. Progression of aortic valve stenosis in adults: a systematic review. J Heart Valve Dis 2012;21(4):454–62.</mixed-citation><mixed-citation xml:lang="ru">Heuvelman H.J., van Geldorp M.W., Eijkemans M.J. et al. Progression of aortic valve stenosis in adults: a systematic review. J Heart Valve Dis 2012;21(4):454–62.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Raisz L.G. Clinical practice. Screening for Osteoporosis. N Engl J Med 2005;353(2):164–71.</mixed-citation><mixed-citation xml:lang="ru">Raisz L.G. Clinical practice. Screening for Osteoporosis. N Engl J Med 2005;353(2):164–71.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Карпова Н.Ю., Рашид М.А., Шоста к Н.А., Казакова Т.В. Кальцинированный аортальный стеноз и остеопороз: общие механизмы и перспективы фармакологической коррекции. Клиницист 2011;(2):86–96.</mixed-citation><mixed-citation xml:lang="ru">Карпова Н.Ю., Рашид М.А., Шоста к Н.А., Казакова Т.В. Кальцинированный аортальный стеноз и остеопороз: общие механизмы и перспективы фармакологической коррекции. Клиницист 2011;(2):86–96.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
