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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">The Clinician</journal-id><journal-title-group><journal-title xml:lang="en">The Clinician</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиницист</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8338</issn><issn publication-format="electronic">2412-8775</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">410</article-id><article-id pub-id-type="doi">10.17650/1818-8338-2019-13-3-4-59-66</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CASE REPORT</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОПИСАНИЕ СЛУЧАЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Osteomalation under the mask of spondyloarthritis</article-title><trans-title-group xml:lang="ru"><trans-title>Остеомаляция под маской спондилоартрита</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7393-1063</contrib-id><name-alternatives><name xml:lang="en"><surname>Shulman</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Шульман</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>30 Bolshaya Pod'yacheskaya St., St. Petersburg 190068</p></bio><bio xml:lang="ru"><p>Александр Михайлович Шульман</p><p>190068 Санкт-Петербург, ул. Большая Подъяческая, 30</p></bio><email>alshulman@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0143-0614</contrib-id><name-alternatives><name xml:lang="en"><surname>Lesnyak</surname><given-names>O. M.</given-names></name><name xml:lang="ru"><surname>Лесняк</surname><given-names>О. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>30 Bolshaya Pod'yacheskaya St., St. Petersburg 19006841 Kirochnaya St., St. Petersburg 191015</p></bio><bio xml:lang="ru"><p>190068 Санкт-Петербург, ул. Большая Подъяческая, 30191015 Санкт-Петербург, ул. Кирочная, 41</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3500-7256</contrib-id><name-alternatives><name xml:lang="en"><surname>Gaidukova</surname><given-names>I. Z.</given-names></name><name xml:lang="ru"><surname>Гайдукова</surname><given-names>И. З.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>30 Bolshaya Pod'yacheskaya St., St. Petersburg 19006841 Kirochnaya St., St. Petersburg 191015</p></bio><bio xml:lang="ru"><p>190068 Санкт-Петербург, ул. Большая Подъяческая, 30191015 Санкт-Петербург, ул. Кирочная, 41</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9181-0695</contrib-id><name-alternatives><name xml:lang="en"><surname>Surmina</surname><given-names>L. P.</given-names></name><name xml:lang="ru"><surname>Сурмина</surname><given-names>Л. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>30 Bolshaya Pod'yacheskaya St., St. Petersburg 190068</p></bio><bio xml:lang="ru"><p>190068 Санкт-Петербург, ул. Большая Подъяческая, 30</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5035-2800</contrib-id><name-alternatives><name xml:lang="en"><surname>Ushakova</surname><given-names>E. N.</given-names></name><name xml:lang="ru"><surname>Ушакова</surname><given-names>Е. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>30 Bolshaya Pod'yacheskaya St., St. Petersburg 190068</p></bio><bio xml:lang="ru"><p>190068 Санкт-Петербург, ул. Большая Подъяческая, 30</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0363-9614</contrib-id><name-alternatives><name xml:lang="en"><surname>Polikarpova</surname><given-names>T. V.</given-names></name><name xml:lang="ru"><surname>Поликарпова</surname><given-names>Т. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>30 Bolshaya Pod'yacheskaya St., St. Petersburg 190068</p></bio><bio xml:lang="ru"><p>190068 Санкт-Петербург, ул. Большая Подъяческая, 30</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3375-2471</contrib-id><name-alternatives><name xml:lang="en"><surname>Vasilyeva</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Васильева</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>30 Bolshaya Pod'yacheskaya St., St. Petersburg 190068</p></bio><bio xml:lang="ru"><p>190068 Санкт-Петербург, ул. Большая Подъяческая, 30</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Inamova</surname><given-names>O. V.</given-names></name><name xml:lang="ru"><surname>Инамова</surname><given-names>О. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>30 Bolshaya Pod'yacheskaya St., St. Petersburg 190068</p></bio><bio xml:lang="ru"><p>190068 Санкт-Петербург, ул. Большая Подъяческая, 30</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Clinical Rheumatological Hospital No. 25</institution></aff><aff><institution xml:lang="ru">СПб ГБУЗ «Клиническая ревматологическая больница № 25»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">North-West State Medical University named after I. I. Mechnikov</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И. И. Мечникова»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2019-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2019</year></pub-date><volume>13</volume><issue>3-4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>59</fpage><lpage>66</lpage><history><date date-type="received" iso-8601-date="2020-01-30"><day>30</day><month>01</month><year>2020</year></date><date date-type="accepted" iso-8601-date="2020-01-30"><day>30</day><month>01</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2019, Shulman A.M., Lesnyak O.M., Gaidukova I.Z., Surmina L.P., Ushakova E.N., Polikarpova T.V., Vasilyeva E.V., Inamova O.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2019, Шульман А.М., Лесняк О.М., Гайдукова И.З., Сурмина Л.П., Ушакова Е.Н., Поликарпова Т.В., Васильева Е.В., Инамова О.В.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="en">Shulman A.M., Lesnyak O.M., Gaidukova I.Z., Surmina L.P., Ushakova E.N., Polikarpova T.V., Vasilyeva E.V., Inamova O.V.</copyright-holder><copyright-holder xml:lang="ru">Шульман А.М., Лесняк О.М., Гайдукова И.З., Сурмина Л.П., Ушакова Е.Н., Поликарпова Т.В., Васильева Е.В., Инамова О.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://klinitsist.abvpress.ru/Klin/article/view/410">https://klinitsist.abvpress.ru/Klin/article/view/410</self-uri><abstract xml:lang="en"><p><bold>Objective.</bold> To demonstrate the possibility of having a spondyloarthritic mask of osteomalacia in patients of both sexes.</p><p><bold>Materials and methods.</bold> Two clinical cases of osteomalacia occurring under the mask of spondyloarthritis in patients treated at the Clinical Rheumatology Hospital of Saint-Petersburg, Russia, as well as similar cases described in the literature, were analyzed.</p><p><bold>Results.</bold> In the cases described, patients were diagnosed with a disease from the group of spondyloarthritis based on a number of individual symptoms, such as pain in the lower back and stiffness, as well as instrumental examination data. At the same time, with in-depth evaluation, the pain in the lower back did not did not met to the inflammatory pain ASAS criteria, and there were also no signs of general laboratory activity of the disease. The conventional therapy for spondyloarthritis was ineffective. With the re-evaluation of clinical, laboratory and instrumental data, the diagnosis was changed to osteomalacia. Appointment of adequate therapy with vitamin D after a review of the diagnosis resulted in both a regression of clinical symptoms and an improvement in laboratory parameters.</p><p><bold>Conclusions.</bold> If the patient has pain in the lower back, especially without clear signs of inflammatory, no signs of general laboratory activity, further examination is necessary to clarify possible osteomalacia. Spondyloarthritis should be only diagnosed in cases with the secondary nature of symptoms excluded.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель исследования</bold> – продемонстрировать возможность спондилоартритической маски остеомаляции у пациентов обоих полов.</p><p><bold>Материалы и методы.</bold> Проанализированы 2 клинических случая остеомаляции, протекавших под маской спондилоартрита у пациентов, находившихся на лечении в СПб ГБУЗ «Клиническая ревматологическая больница № 25», а также подобные случаи, отраженные в литературе.</p><p><bold>Результаты.</bold> В описанных случаях у пациентов на основании ряда отдельных симптомов, таких как боль в нижней части спины и скованность, а также данных инструментального обследования первоначально диагностировалось заболевание из группы спондилоартритов. При этом при углубленной оценке боль в нижней части спины не имела признаков воспалительной по критериям ASAS, кроме того, отсутствовали признаки общелабораторной активности заболевания. Терапия препаратами, использующимися в курации спондилоартритов, эффекта не давала. При повторной оценке клинических данных, результатов лабораторного и инструментального обследований диагноз был пересмотрен в пользу остеомаляции. Назначение адекватной терапии препаратами витамина D после пересмотра диагноза приводило как к регрессу клинических симптомов, так и к улучшению лабораторных показателей.</p><p><bold>Заключение.</bold> При наличии у пациента болей в нижней части спины, особенно без четких признаков воспалительной, и отсутствии признаков общелабораторной активности необходимо дообследование для уточнения возможной остеомаляции. Диагноз спондилоартрита должен выставляться только после исключения вторичного характера симптомов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>spodiloarthritis</kwd><kwd>osteomalacia</kwd><kwd>rheumatologic mask</kwd><kwd>overdiagnosis of spondyloarthritis</kwd><kwd>Looser line</kwd><kwd>inflammatory back pain</kwd><kwd>lower back pain</kwd><kwd>sacroiliitis</kwd><kwd>osteoporosis</kwd><kwd>vitamin D</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>сподилоартрит</kwd><kwd>остеомаляция</kwd><kwd>ревматологическая маска</kwd><kwd>гипердиагностика спондилоартрита</kwd><kwd>линия Лоозера</kwd><kwd>воспалительная боль в спине</kwd><kwd>боль в нижней части спины</kwd><kwd>сакроилиит</kwd><kwd>остеопороз</kwd><kwd>витамин D</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Russian clinical guidelines. Rheumatology Eds. by E.L. Nasonov. Moskow: GEOTAR-Media, 2017. 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