The ClinicianThe ClinicianКлиницист1818-83382412-8775Publishing House ABV Press3610.17650/1818-8338-2013-1-9-13REVIEWОБЗОРTHE ROLE OF INFECTION IN PATHOGENESIS OF ATHEROGENOUS INFLAMMATORY PROCESSРОЛЬ ИНФЕКЦИИ В ПАТОГЕНЕЗЕ АТЕРОГЕННОГО ВОСПАЛИТЕЛЬНОГО ПРОЦЕССАPavlovO. N.ПавловО. Н.
Russian Federation
o.n.pavlov@mail.ruRoad Clinical Hospital at the Yaroslavl station of Russian RailwaysНУЗ «Дорожная клиническая больница на станции Ярославль ОАО «РЖД»15012013719131507201415072014Copyright ©; 2013, Pavlov O.N.Copyright ©; 2013, Павлов О.Н.2013Pavlov O.N.Павлов О.Н.https://creativecommons.org/licenses/by/4.0https://klinitsist.abvpress.ru/Klin/article/view/36

Clinical manifestations of atherosclerosis are the most significant medical, social and economic challenge of our time, distant from its decision. Research study of atherogenesis at the cellular level, communication mediators and receptor-activation reactions indirect immunocompetent cells identify pathogenetic parts of the atherosclerotic process. In this article the role of infectious agents in formation of endothelial dysfunction, development of system inflammatory response and lipid transformation of the vascular wall, underlying an atherosclerosisis surveyed.

Клинические проявления атеросклероза являются наиболее значимой медицинской, социальной и экономической проблемой современности, далекой от своего решения. Исследования по изучению атерогенеза на клеточном уровне, взаимодействия медиаторов и рецепторопосредованных реакций активации иммунокомпетентных клеток позволяют определить патогенетические звенья атеросклеротического процесса. В данной статье рассмотрена роль инфекционных агентов в формировании дисфункции эндотелия, развитии системной воспалительной реакции и липидной трансформации сосудистой стенки, лежащих в основе атеросклероза.

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