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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">The Clinician</journal-id><journal-title-group><journal-title xml:lang="en">The Clinician</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиницист</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8338</issn><issn publication-format="electronic">2412-8775</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">258</article-id><article-id pub-id-type="doi">10.17650/1818-8338-2016-10-2-43-49</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>LECTION</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">MYOCARDIAL INFARCTION TYPE 4TH: FEATURES OF THE COURSE, PREVENTION AND MANAGEMENT OF PATIENTS AFTER PERCUTANEOUS CORONARY INTERVENTIONS</article-title><trans-title-group xml:lang="ru"><trans-title>ИНФАРКТ МИОКАРДА 4-ГО ТИПА: ОСОБЕННОСТИ ТЕЧЕНИЯ, ПРОФИЛАКТИКА И ВЕДЕНИЕ БОЛЬНЫХ ПОСЛЕ ЧРЕСКОЖНЫХ КОРОНАРНЫХ ВМЕШАТЕЛЬСТВ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pravdyuk</surname><given-names>N. G.</given-names></name><name xml:lang="ru"><surname>Правдюк</surname><given-names>Н. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A.I. Nesterov Department of Faculty Therapy, </p><p>1 Ostrovityanova St., Moscow, 117997</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А.И. Нестерова,</p><p>117997, Москва, ул. Островитянова, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Novikova</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Новикова</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A.I. Nesterov Department of Faculty Therapy, </p><p>1 Ostrovityanova St., Moscow, 117997</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А.И. Нестерова,</p><p>117997, Москва, ул. Островитянова, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Korolyеv</surname><given-names>E. A.</given-names></name><name xml:lang="ru"><surname>Королева</surname><given-names>Е. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A.I. Nesterov Department of Faculty Therapy, </p><p>1 Ostrovityanova St., Moscow, 117997</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А.И. Нестерова,</p><p>117997, Москва, ул. Островитянова, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.I. Pirogov Russian National Research Medical University of the Ministhy&#13;
of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2016</year></pub-date><volume>10</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>43</fpage><lpage>49</lpage><history><date date-type="received" iso-8601-date="2016-09-16"><day>16</day><month>09</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-09-16"><day>16</day><month>09</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Pravdyuk N.G., Novikova A.V., Korolyеv E.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, Правдюк Н.Г., Новикова А.В., Королева Е.А.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Pravdyuk N.G., Novikova A.V., Korolyеv E.A.</copyright-holder><copyright-holder xml:lang="ru">Правдюк Н.Г., Новикова А.В., Королева Е.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://klinitsist.abvpress.ru/Klin/article/view/258">https://klinitsist.abvpress.ru/Klin/article/view/258</self-uri><abstract xml:lang="en"><p>To date, cardiovascular diseases occupy the first place in the structure of total morbidity and mortality in many countries. In 2013 in the Russian Federation from cardiovascular disease died 1 million 799 thousand people, from the bottom 529.8 thousand from coronary heart disease, the primary role belongs to myocardial infarction and its complications. Currently, the "gold standard" for the diagnosis of coronary heart disease, including myocardial infarction, remains coronary angiography; the main objectives of coronary angiography are to assess the features of the coronary anatomy, determination of the possibility of endovascular treatment of myocardial infarction and revascularization by stent implantation. Despite the constant improvement of technology and the progress made in relation to pharmacological support, percutaneous coronary intervention (PCI) is an invasive manipulation, which is associated with a certain risk. Diagnostic criteria for myocardial infarction 4a type include increasing the level of troponin above 5 rules of 99th the upper threshold reference values within 48 hours after the PCI procedure, in patients with normal troponin increased (≤ 99th the upper threshold reference values), or a level of troponin 20 % or more in patients with initial high level troponin combined with evidence of prolonged myocardial ischemia. Stent when performing percutaneous coronary interventions, accompanied by the activation of thrombogenic reactions, can lead to thrombosis and development 4b type. To the diagnostic signs of the myocardial infarction 4b type are the stent thrombosis, angiographic proven and/or at autopsy, in combination with increased troponin level at least one greater than the 99th the upper threshold reference values. Stent when performing PCI, accompanied by the activation of thrombogenic reactions, can lead to thrombosis and development myocardial infarction 4b type. The diagnostic signs myocardial infarction 4b type are the stent thrombosis, angiographic proven and/or at autopsy, in combination with increased troponin level at least one greater than the 99th the upper threshold reference values. You should consider the fact that the setting of drug-eluting stents increases the period of their endothelization after implantation, which in turn increases the likelihood of late thrombosis and is an indication for long-term dual antiplatelet therapy. The article describes the varieties of myocardial infarction associated with PCI, an algorithm for the diagnosis and management of patients in accordance with current clinical recommendations.</p></abstract><trans-abstract xml:lang="ru"><p>На сегодняшний день сердечно-сосудистые заболевания занимают 1-е место в структуре общей заболеваемости и смертности во многих странах мира. В 2013 г. в Российской Федерации от сердечно-сосудистых заболеваний умерли 1 млн 799 тыс. человек, из них 529,8 тыс. – от ишемической болезни сердца, при этом ведущая роль принадлежит инфаркту миокарда (ИМ) и его осложнениям. В настоящее время «золотым стандартом» диагностики ишемической болезни сердца, в том числе ИМ, по-прежнему остается коронароангиография, основными задачами которой являются не только оценка особенностей коронарной анатомии, но и определение возможности проведения эндоваскулярного лечения ИМ и реваскуляризации миокарда путем имплантации стента. Несмотря на постоянное совершенствование техники и прогресс, достигнутый в отношении фармакологической поддержки, чрескожное коронарное вмешательство (ЧКВ) является инвазивной манипуляцией, проведение которой сопряжено с определенным риском. Диагностические критерии ИМ типа 4а включают повышение уровня тропонина свыше 5 норм 99-го перцентиля верхних референсных значений (ПВРЗ) в течение 48 ч после процедуры ЧКВ у пациентов с исходно нормальным показателем тропонина (≤ 99-го ПВРЗ) или повышение уровня тропонина на 20 % и более у пациентов с исходно высоким уровнем тропонина в сочетании с признаками длительной ишемии миокарда. Установка стента при проведении ЧКВ, сопровождающаяся активацией тромбогенных реакций, может привести к его тромбозу и развитию ИМ типа 4б. Кдиагностическим признакам ИМ типа 4б относятся тромбоз стента, доказанный ангиографически и/или на аутопсии, в сочетании с повышением уровня тропонина по крайней мере на 1 значение больше 99-го ПВРЗ. Следует учитывать тот факт, что установка стентов с лекарственным покрытием увеличивает период их реэндотелизации после имплантации, что, в свою очередь, повышает вероятность развития поздних тромбозов и является показанием для проведения длительной двойной антиагрегантной терапии. В статье представлены разновидности ИМ, ассоциированные с ЧКВ, алгоритм диагностики и ведения пациентов в соответствии с современными клиническими рекомендациями.</p></trans-abstract><kwd-group xml:lang="en"><kwd>cardiovascular disease</kwd><kwd>coronary heart disease</kwd><kwd>myocardial infarction 4th types percutaneous coronary intervention</kwd><kwd>percutaneous coronary intervention success</kwd><kwd>diagnostic criteria of myocardial infarction 4th type</kwd><kwd>troponin</kwd><kwd>stenting</kwd><kwd>stent thrombosis</kwd><kwd>restenosis of the stent</kwd><kwd>dissection of the coronary arteries</kwd><kwd>the phenomenon of slow-no-reflow</kwd><kwd>dual antiplatelet therapy</kwd><kwd>aspirin</kwd><kwd>clopidogrel</kwd><kwd>statins</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>сердечно-сосудистые заболевания</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>инфаркт миокарда 4-го типа</kwd><kwd>чреcкожное коронарное вмешательство</kwd><kwd>успех чреcкожного коронарного вмешательства</kwd><kwd>диагностические критерии инфаркта миокарда 4-го типа</kwd><kwd>тропонин</kwd><kwd>стентирование</kwd><kwd>тромбоз стента</kwd><kwd>рестеноз стента</kwd><kwd>диссекция коронарных артерий</kwd><kwd>феномен slow-nо-reflow</kwd><kwd>двойная антиагрегантная терапия</kwd><kwd>аспирин</kwd><kwd>клопидогрел</kwd><kwd>статины</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. 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