The ClinicianThe ClinicianКлиницист1818-83382412-8775Publishing House ABV Press2310.17650/1818-8338-2013-2-14-17REVIEWОБЗОРIMPACT OF ANGIOTENSIN-CONVERTING ENZYME GENE POLYMORPHISM ON THE DEVELOPMENT OF INSULIN RESISTANCE SYNDROMEВлияние полиморфизма гена ангиотензинпревращающего фермента на формирование синдрома инсулинорезистентностиRoitbergG. E.РойтбергГ. Е.
Russian Federation
DoroshZh. V.ДорошЖ. В.
Russian Federation
AksenovE. V.АксеновЕ. В.
Russian Federation
UshakovaT. I.УшаковаТ. И.
Russian Federation
tatyana_ushakova@medicina.ruN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaГБОУ ВПО «Российский научно-исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России150420137214171407201414072014Copyright ©; 2013, Roitberg G.E., Dorosh Z.V., Aksenov E.V., Ushakova T.I.Copyright ©; 2013, Ройтберг Г.Е., Дорош Ж.В., Аксенов Е.В., Ушакова Т.И.2013Roitberg G.E., Dorosh Z.V., Aksenov E.V., Ushakova T.I.Ройтберг Г.Е., Дорош Ж.В., Аксенов Е.В., Ушакова Т.И.https://creativecommons.org/licenses/by/4.0https://klinitsist.abvpress.ru/Klin/article/view/23

Objective: to analyze the distribution of components of insulin resistance (IR) syndrome and to study the frequency of their combinations in relation to the genotypes and allelic variants of the angiotensin-converting enzyme (ACE) gene.

Subjects and methods. A group of clinically healthy patients (50 women and 42 men) with different genotypes of the ACE gene was examined.The distribution of IR syndrome components and the frequency of their combinations were analyzed in relation to the genotypes and allelicvariants of the ACE gene.

Results. A group of D allele carriers compared to A allele ones showed a pronounced tendency for the frequency of IR to reduce due to thehigher proportion of patients with complete IR syndrome. This observation becomes statistically significant in the assessment of homozygous variants of the ACE gene. At the same time dyslipidemia and hypertension in the presence of IR significantly more frequently occurred in patients with the DD genotype than in those with genotype II.

Conclusion. There was a marked predominance of the manifestations of IR syndrome with a complete set of components in the DD genotypicgroup, which confirms the significant strong association between ACE gene polymorphism and IR syndrome.

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