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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">The Clinician</journal-id><journal-title-group><journal-title xml:lang="en">The Clinician</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиницист</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8338</issn><issn publication-format="electronic">2412-8775</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">215</article-id><article-id pub-id-type="doi">10.17650/1818-8338-2012-6-2-23-26</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">A COMPREHENSIVE ANALYSIS DIABETES OF RISK FACTORS IN PATIENTS WITH CHRONIC PANCREATITIS</article-title><trans-title-group xml:lang="ru"><trans-title>КОМПЛЕКСНЫЙ АНАЛИЗ ФАКТОРОВ РИСКА САХАРНОГО ДИАБЕТА У БОЛЬНЫХ ХРОНИЧЕСКИМ ПАНКРЕАТИТОМ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kunitsyna</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Куницына</surname><given-names>М. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>kounitsyna@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shestakova</surname><given-names>M. V.</given-names></name><name xml:lang="ru"><surname>Шестакова</surname><given-names>М. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">V.I. Razumovsky Saratov State Medical University, Ministry of Health, Saratov</institution></aff><aff><institution xml:lang="ru">ГОУ ВПО «Саратовский государственный медицинский университет им. В.И. Разумовского» Минздрава России, Саратов</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Endocrinology Research Center, Moscow</institution></aff><aff><institution xml:lang="ru">ФГБУ «Эндокринологический научный центр», Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2012</year></pub-date><volume>6</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>23</fpage><lpage>26</lpage><history><date date-type="received" iso-8601-date="2015-10-15"><day>15</day><month>10</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-10-15"><day>15</day><month>10</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, Kunitsyna M.A., Shestakova M.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, Куницына М.А., Шестакова М.В.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">Kunitsyna M.A., Shestakova M.V.</copyright-holder><copyright-holder xml:lang="ru">Куницына М.А., Шестакова М.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://klinitsist.abvpress.ru/Klin/article/view/215">https://klinitsist.abvpress.ru/Klin/article/view/215</self-uri><abstract xml:lang="en"><p>Aim – to perform comprehensive analysis of the risk factors of diabetes mellitus (DM) in patients with chronic pancreatitis (CP). Materials and methods. All examined patients with chronic pancreatitis (CP) were divided into 2 groups. The first group – 38 patients with the progression of the diabetes in the first 3 years of the CP, the second – 44 people with no diabetes after 10 years of disease. Formation of CP etiologic groups based on the mandatory presence of one of two factors: alcohol abuse, the presence of disease of biliary system. The combination of two etiological factors wasl exclusion criteria. Results and conclusion. Among the examined patients biliary form of CP occurred in 52 patients, alcohol – in 30 patients. It was found that in the first three years of CP risk of diabetes is not associated with family history, obesity, number of exacerbations, but in the form of alcoholic CP DM formed almost two times more often than in the biliary. When combined with CP in patients with diabetes were significantly more common strain of the main flow and structural changes in the tail of the pancreas.</p></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>chronic pancreatitis</kwd><kwd>diabetes mellitus</kwd><kwd>the risk of development</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>хронический панкреатит</kwd><kwd>сахарный диабет</kwd><kwd>риск развития</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Винокурова Л.В., Астафьева О.В. Взаимосвязь экзокринной и эндокринной функций поджелудочной железы при хроническом алкогольном панкреатите. Экспер. и клин. гастроэнтерол 2002;(4):58–61.</mixed-citation><mixed-citation xml:lang="ru">Винокурова Л.В., Астафьева О.В. Взаимосвязь экзокринной и эндокринной функций поджелудочной железы при хроническом алкогольном панкреатите. Экспер. и клин. гастроэнтерол 2002;(4):58–61.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Дробижев М.Ю., Суркова Е.В., Мельникова О.Г. Эпидемиология сахарного диабета у больных, наблюдающихся терапевтами, кардиологами, неврологами. Consilium medicum 2008;10(12):92–6.</mixed-citation><mixed-citation xml:lang="ru">Дробижев М.Ю., Суркова Е.В., Мельникова О.Г. Эпидемиология сахарного диабета у больных, наблюдающихся терапевтами, кардиологами, неврологами. Consilium medicum 2008;10(12):92–6.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Malka D., Hammel P. Can the natural history of diabetes be changed in chronic pancreatitis? Gastroenterol Clin Biol 2003;27:45–50.</mixed-citation><mixed-citation xml:lang="ru">Malka D., Hammel P. Can the natural history of diabetes be changed in chronic pancreatitis? Gastroenterol Clin Biol 2003;27:45–50.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Ewald N., Kaufmann C., Raspe A. et al. Prevalence of diabetes mellitus secondary to pancreatic diseases (type 3c). Pancreatology 2006;6:394.</mixed-citation><mixed-citation xml:lang="ru">Ewald N., Kaufmann C., Raspe A. et al. Prevalence of diabetes mellitus secondary to pancreatic diseases (type 3c). Pancreatology 2006;6:394.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Rothenbacher D., Löw M., Hardt P.D. et al. Prevalence and determinants of exocrine pancreatic insufficiency among older adults: Results of a population-based study. Scand J Gastroenterol 2005;40:697–704.</mixed-citation><mixed-citation xml:lang="ru">Rothenbacher D., Löw M., Hardt P.D. et al. Prevalence and determinants of exocrine pancreatic insufficiency among older adults: Results of a population-based study. Scand J Gastroenterol 2005;40:697–704.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Комаров Ф.И., Гидаятов А.А. Поджелудочная железа как эндокринный орган (об-зор литературы). Мед РЖ 1987;(1):24–38.</mixed-citation><mixed-citation xml:lang="ru">Комаров Ф.И., Гидаятов А.А. Поджелудочная железа как эндокринный орган (об-зор литературы). Мед РЖ 1987;(1):24–38.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Губергриц Н.Б., Лукашевич Г.М., Голубова О.А. и др. Панкреатогeнный сахарный диабет. Рос. журн. гастроэнтерол, гепатол. и колопроктол. 2007;(6):12–6.</mixed-citation><mixed-citation xml:lang="ru">Губергриц Н.Б., Лукашевич Г.М., Голубова О.А. и др. Панкреатогeнный сахарный диабет. Рос. журн. гастроэнтерол, гепатол. и колопроктол. 2007;(6):12–6.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Cui Y.F., Andersen D.K. Pancreatogenic diabetes: Special considerations for management. Pancreatology 2011;11:279–94.</mixed-citation><mixed-citation xml:lang="ru">Cui Y.F., Andersen D.K. Pancreatogenic diabetes: Special considerations for management. Pancreatology 2011;11:279–94.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Onodera M., Okazaki K., Morita M. et al. Immune complex specific for the pancreatic duct antigen in patients with idiopathic chronic pancreatitis and Sjogren syndrome. Autoimmunity 1994;19:23–9.</mixed-citation><mixed-citation xml:lang="ru">Onodera M., Okazaki K., Morita M. et al. Immune complex specific for the pancreatic duct antigen in patients with idiopathic chronic pancreatitis and Sjogren syndrome. Autoimmunity 1994;19:23–9.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Kloppel G, Solcia E, Longnecker D. et al. Histological typing of tumors of the exocrine pancreas. WHO International Histological Classification of Tumors. Second edition. Berlin, Heidelberg, New York: WHO; 1996.</mixed-citation><mixed-citation xml:lang="ru">Kloppel G, Solcia E, Longnecker D. et al. Histological typing of tumors of the exocrine pancreas. WHO International Histological Classification of Tumors. Second edition. Berlin, Heidelberg, New York: WHO; 1996.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
