The ClinicianThe ClinicianКлиницист1818-83382412-8775Publishing House ABV Press20710.17650/1818-8338-2015-9-3-28-33ORIGINAL INVESTIGATIONSОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕVASCULAR WALL STIFFNESS IN PATIENTS WITH ANKYLOSING SPONDYLITIS: RESULTS OF A MULTICENTER STUDYЖЕСТКОСТЬ СОСУДИСТОЙ СТЕНКИ У ПАЦИЕНТОВ С АНКИЛОЗИРУЮЩИМ СПОНДИЛИТОМ (результаты многоцентрового исследования)GaydukovaI. Z.ГайдуковаИ. З.
Russian Federation
ubp1976@list.ruMaslyanskyA. L.МаслянскийА. Л.
Russian Federation
PolyanskayaO. L.ПолянскаяО. Л.
Russian Federation
KolesovaE. P.КолесоваЕ. П.
Russian Federation
RebrovA. P.РебровА. П.
Russian Federation
KonradiA. O.КонрадиА. О.
Russian Federation
V.I. Razumovsky Saratov State Medical University, Ministry of Health of RussiaГБОУ ВПО «Саратовский государственный медицинский университет им. В.И. Разумовского» Минздрава России112 Bolshaya Kazachya St., Saratov, 410012, RussiaРоссия, 410012, Саратов, Большая Казачья, 112V.A. Almazov Federal Medical Research Center, Ministry of Health of RussiaФГБУ «Федеральный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России22 Akkuratov St., Saint Petersburg, 190000, RussiaРоссия, 190000, Санкт­Петербург, ул. Аккуратова, 2150720159328331210201512102015Copyright ©; 2015, Gaydukova I.Z., Maslyansky A.L., Polyanskaya O.L., Kolesova E.P., Rebrov A.P., Konradi A.O.Copyright ©; 2015, Гайдукова И.З., Маслянский А.Л., Полянская О.Л., Колесова Е.П., Ребров А.П., Конради А.О.2015Gaydukova I.Z., Maslyansky A.L., Polyanskaya O.L., Kolesova E.P., Rebrov A.P., Konradi A.O.Гайдукова И.З., Маслянский А.Л., Полянская О.Л., Колесова Е.П., Ребров А.П., Конради А.О.https://creativecommons.org/licenses/by/4.0https://klinitsist.abvpress.ru/Klin/article/view/207

Objective: to study some vascular wall stiffness parameters in patients with ankylosing spondylitis (AS) without clinically manifest cardio­ vascular diseases. Subjects and methods. One hundred and six patients with AS and 21 healthy volunteers without cardiovascular diseases who were matched for age, gender, and cardiovascular risk were examined at two centers. Cardiovascular risk and vascular wall stiffness (augmentation index and pulse wave propagation velocity (PWPV)) were assessed by oscillography. Results. Vascular wall stiffness was comparable in the patients with AS (at both centers) and in the healthy individuals. PWPV was 7.45 (5.4–8.71) m/sec in the AS patients (n = 106) and 8.53 (6.28–9.5) m/sec in the healthy individuals (n = 21); the aortic augmentation in­ dex was 15.6 (7.9–31.1) and 21.1 (10.2–24) %, respectively; p > 0.05 for all. Correlation analysis revealed associations between aug­ mentation index, age, blood pressure, disease activity (BASDAI) and spine mobility (BASMI) scores. Conclusion. The vascular wall stiffness did not differ between AS patients without cardiovascular diseases and cardiovascular risk­matched healthy individuals. Its parameters were related to age, blood pressure, and disease activity (BASDAI) and axial skeleton immobility (BASMI) indices. 

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