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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">The Clinician</journal-id><journal-title-group><journal-title xml:lang="en">The Clinician</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиницист</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8338</issn><issn publication-format="electronic">2412-8775</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">205</article-id><article-id pub-id-type="doi">10.17650/1818-8338-2015-9-3-15-21</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">CURRENT POSSIBILITIES OF ANTICOAGULANT THERAPY IN PATIENTS WITH ATRIAL FIBRILLATION</article-title><trans-title-group xml:lang="ru"><trans-title>СОВРЕМЕННЫЕ ВОЗМОЖНОСТИ АНТИКОАГУЛЯНТНОЙ ТЕРАПИИ БОЛЬНЫХ С ФИБРИЛЛЯЦИЕЙ ПРЕДСЕРДИЙ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gilyarov</surname><given-names>M. Yu.</given-names></name><name xml:lang="ru"><surname>Гиляров</surname><given-names>М. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Konstantinova</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Константинова</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>katekons@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Trukhin</surname><given-names>A. I.</given-names></name><name xml:lang="ru"><surname>Трухин</surname><given-names>А. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff8"/><xref ref-type="aff" rid="aff9"/><xref ref-type="aff" rid="aff10"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Regional Vascular Center, N.I. Pirogov City Clinical Hospital One, Moscow Healthcare Department</institution></aff><aff><institution xml:lang="ru">Региональный сосудистый центр ГБУЗ г. Москва «Городская клиническая больница No 1 им. Н.И. Пирогова Департамента здравоохранения г. Москвы»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">8 Leninsky Prospect, Build. 8, Moscow, 115149, Russia</institution></aff><aff><institution xml:lang="ru">Россия, 115149, Москва, Ленинский пр­т, 8, корп. 8</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Department of Emergency and Preventive Cardiology, I.M. Sechenov First Moscow State Medical University,&#13;
Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">Кафедра неотложной и профилактической кардиологии ГБОУ ВПО «Первый МГМУ им. И.М. Сеченова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">8 Trubetskaya St., Build. 2, Moscow, 119991, Russia</institution></aff><aff><institution xml:lang="ru">Россия, 119991, Москва, ул. Трубецкая, 8, стр. 2</institution></aff></aff-alternatives><aff id="aff5"><institution></institution></aff><aff-alternatives id="aff6"><aff><institution xml:lang="en">Acad. A.I. Nesterov Department of Intermediate­Level Therapy, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, 1 Ostrovityanov St., Moscow 117997, Russia</institution></aff><aff><institution xml:lang="ru">Кафедра факультетской терапии им. акад. А.И. Нестерова ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="ru">Россия, 117997, Москва, ул. Островитянова, 1</institution></aff><aff><institution xml:lang="en">Regional Vascular Center, N.I. Pirogov City Clinical Hospital One, Moscow Healthcare Department</institution></aff></aff-alternatives><aff-alternatives id="aff8"><aff><institution xml:lang="en">8 Leninsky Prospect, Build. 8, Moscow, 115149, Russia</institution></aff><aff><institution xml:lang="ru">Региональный сосудистый центр ГБУЗ г. Москва «Городская клиническая больница No 1 им. Н.И. Пирогова Департамента здравоохранения г. Москвы»</institution></aff></aff-alternatives><aff-alternatives id="aff9"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Россия, 115149, Москва, Ленинский пр­т, 8, корп. 8</institution></aff></aff-alternatives><aff id="aff10"><institution></institution></aff><pub-date date-type="pub" iso-8601-date="2015-07-15" publication-format="electronic"><day>15</day><month>07</month><year>2015</year></pub-date><volume>9</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>15</fpage><lpage>21</lpage><history><date date-type="received" iso-8601-date="2015-10-12"><day>12</day><month>10</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-10-12"><day>12</day><month>10</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Gilyarov M.Y., Konstantinova E.V., Trukhin A.I.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, Гиляров М.Ю., Константинова Е.В., Трухин А.И.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Gilyarov M.Y., Konstantinova E.V., Trukhin A.I.</copyright-holder><copyright-holder xml:lang="ru">Гиляров М.Ю., Константинова Е.В., Трухин А.И.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://klinitsist.abvpress.ru/Klin/article/view/205">https://klinitsist.abvpress.ru/Klin/article/view/205</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>atrial fibrillation</kwd><kwd>cardiac embolism risk</kwd><kwd>ischemic stroke</kwd><kwd>vitamin K antagonists</kwd><kwd>warfarin</kwd><kwd>novel oral anticoagulants</kwd><kwd>acetyl­ salicylic acid</kwd><kwd>anticoagulant therapy safety</kwd><kwd>CHA2DS2­VASc scale</kwd><kwd>HAS­BLED scale</kwd><kwd>left atrial appendage occluders</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>фибрилляция предсердий</kwd><kwd>риск кардиоэмболий</kwd><kwd>ишемический инсульт</kwd><kwd>антагонисты витамина К</kwd><kwd>варфарин</kwd><kwd>новые пероральные антикоагулянты</kwd><kwd>ацетилсалициловая кислота</kwd><kwd>безопасность антикоагулянтной терапии</kwd><kwd>шкала CHA2DS2­ VASc</kwd><kwd>шкала HAS­BLED</kwd><kwd>окклюдеры ушка левого предсердия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Диагностика и лечение фибрилляции предсердий. Рекомендации ВНОК, ВНОА, АССХ (2012). http://scardio.ru/content/ Guidelines/FP_rkj_13. pdf. [Diagnostics and therapy of atrial fibrillation. Recommendations of All-Russian Scientific Society of Cardiologists, All-Russian Scientific Society of Arrhythmologists, Society of Cardiosurgeons (2012). URL: http://scardio.ru/content/ Guidelines/FP_rkj_13. pdf. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Диагностика и лечение фибрилляции предсердий. Рекомендации ВНОК, ВНОА, АССХ (2012). http://scardio.ru/content/ Guidelines/FP_rkj_13. pdf. [Diagnostics and therapy of atrial fibrillation. Recommendations of All-Russian Scientific Society of Cardiologists, All-Russian Scientific Society of Arrhythmologists, Society of Cardiosurgeons (2012). URL: http://scardio.ru/content/ Guidelines/FP_rkj_13. pdf. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. European Heart Rhythm Association, European Association for Cardio-Thoracic Surgery, Camm A.J. et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology(ESC). Eur Heart J 2010;31(19):2369–429.</mixed-citation><mixed-citation xml:lang="ru">European Heart Rhythm Association, European Association for Cardio-Thoracic Surgery, Camm A.J. et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology(ESC). Eur Heart J 2010;31(19):2369–429.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Camm A.J., Lip G., De Caterina R. et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation. An update of the 2010 ESC Guidelines for the management of atrial fibrillation developed with the special contribution of the European Heart Rhythm Association. Eur Heart J 2012;33(21):2719–47.</mixed-citation><mixed-citation xml:lang="ru">Camm A.J., Lip G., De Caterina R. et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation. An update of the 2010 ESC Guidelines for the management of atrial fibrillation developed with the special contribution of the European Heart Rhythm Association. Eur Heart J 2012;33(21):2719–47.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. January C.T., Wann L.S., Alpert J.S. et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. Circulation 2014;130(23):2071–104.</mixed-citation><mixed-citation xml:lang="ru">January C.T., Wann L.S., Alpert J.S. et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. Circulation 2014;130(23):2071–104.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Lloyd-Jones D.M., Wang T.J., Leip E.P. et al. Lifetime risk for development of atrial fibrillations: the Framingham Heart Study. Circulation 2004;110(9):1042–6.</mixed-citation><mixed-citation xml:lang="ru">Lloyd-Jones D.M., Wang T.J., Leip E.P. et al. Lifetime risk for development of atrial fibrillations: the Framingham Heart Study. Circulation 2004;110(9):1042–6.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Wolf P.A., Abbott R.D., Kannel W.B. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 1991;22(8):983–8.</mixed-citation><mixed-citation xml:lang="ru">Wolf P.A., Abbott R.D., Kannel W.B. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 1991;22(8):983–8.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Hart R.G., Pearce L.A., Rothbart R.M. et al. Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy. J Am Coll Cardiol 2000;35(1):183–7.</mixed-citation><mixed-citation xml:lang="ru">Hart R.G., Pearce L.A., Rothbart R.M. et al. Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy. J Am Coll Cardiol 2000;35(1):183–7.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Hart R.G., Pearce L.A., Koudstaal P.J. Transient ischemic attacks in patients with atrial fibrillation: implications for secondary prevention: the European Atrial Fibrillation Trial and Stroke Prevention in Atrial Fibrillation III trial. Stroke 2004;35(4):948–51.</mixed-citation><mixed-citation xml:lang="ru">Hart R.G., Pearce L.A., Koudstaal P.J. Transient ischemic attacks in patients with atrial fibrillation: implications for secondary prevention: the European Atrial Fibrillation Trial and Stroke Prevention in Atrial Fibrillation III trial. Stroke 2004;35(4):948–51.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Hohnloser S.H., Pajitnev D., Pogue J. et al. Incidence of stroke in paroxysmal versus sustained atrial fibrillation in patients taking oral anticoagulation or combined antiplatelet therapy: an ACTIVE W Substudy. J Am Coll Cardiol 2007;50(22):2156–61.</mixed-citation><mixed-citation xml:lang="ru">Hohnloser S.H., Pajitnev D., Pogue J. et al. Incidence of stroke in paroxysmal versus sustained atrial fibrillation in patients taking oral anticoagulation or combined antiplatelet therapy: an ACTIVE W Substudy. J Am Coll Cardiol 2007;50(22):2156–61.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Friberg L., Hammar N., Rosenqvist M. Stroke in paroxysmal atrial fibrillation: report from the Stockholm Cohort of Atrial Fibrillation. Eur Heart J 2010;31(8):967–75.</mixed-citation><mixed-citation xml:lang="ru">Friberg L., Hammar N., Rosenqvist M. Stroke in paroxysmal atrial fibrillation: report from the Stockholm Cohort of Atrial Fibrillation. Eur Heart J 2010;31(8):967–75.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Stoddard M.F., Dawkins P.R., Prince C.R., Ammash N.M. Left atrial appendage thrombus is not uncommon in patients with acute atrial fibrillation and a recent embolic event: A transesophageal echocardiographic study. J Am Coll Cardiol 1995;25(2):452–9.</mixed-citation><mixed-citation xml:lang="ru">Stoddard M.F., Dawkins P.R., Prince C.R., Ammash N.M. Left atrial appendage thrombus is not uncommon in patients with acute atrial fibrillation and a recent embolic event: A transesophageal echocardiographic study. J Am Coll Cardiol 1995;25(2):452–9.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Blackshear J.L., Odell J.A. Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation. Ann Thorac Surg 1996;61(2):755–9.</mixed-citation><mixed-citation xml:lang="ru">Blackshear J.L., Odell J.A. Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation. Ann Thorac Surg 1996;61(2):755–9.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Wu N., Tong S., Xiang Y. et al. Association of hemostatic markers with atrial fibrillation: a meta-analysis and meta-regression. PLoS One 2015;10(4):e0124716.</mixed-citation><mixed-citation xml:lang="ru">Wu N., Tong S., Xiang Y. et al. Association of hemostatic markers with atrial fibrillation: a meta-analysis and meta-regression. PLoS One 2015;10(4):e0124716.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Hart R.G., Pearce L.A., Aguilar M.I. Metaanalysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med 2007;146(1):857–67.</mixed-citation><mixed-citation xml:lang="ru">Hart R.G., Pearce L.A., Aguilar M.I. Metaanalysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med 2007;146(1):857–67.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. ACTIVE Investigators, Connolly S.J., Pogue J. Effect of clopidogrel added to aspirin in patients with atrial fibrillation. N Engl J Med 2009;360(20):2066–78.</mixed-citation><mixed-citation xml:lang="ru">ACTIVE Investigators, Connolly S.J., Pogue J. Effect of clopidogrel added to aspirin in patients with atrial fibrillation. N Engl J Med 2009;360(20):2066–78.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Cleland J.G., Cowburn P.J., Falk R.H. Should all patients with atrial fibrillation receive warfarin? Evidence from randomized clinical trials. Eur Heart J 1996;17(5):674–81.</mixed-citation><mixed-citation xml:lang="ru">Cleland J.G., Cowburn P.J., Falk R.H. Should all patients with atrial fibrillation receive warfarin? Evidence from randomized clinical trials. Eur Heart J 1996;17(5):674–81.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Hylek E.M., Skates S.J., Sheehan M.A., Singer D.E. An analysis of the lowest effective intensity of prophylactic anticoagulation for patients with nonrheumatic atrial fibrillation. N Engl J Med 1996;335(8):540–6.</mixed-citation><mixed-citation xml:lang="ru">Hylek E.M., Skates S.J., Sheehan M.A., Singer D.E. An analysis of the lowest effective intensity of prophylactic anticoagulation for patients with nonrheumatic atrial fibrillation. N Engl J Med 1996;335(8):540–6.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Granger C.B., Alexander J.H., McMurray J.J. et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011;365(11):981–92.</mixed-citation><mixed-citation xml:lang="ru">Granger C.B., Alexander J.H., McMurray J.J. et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011;365(11):981–92.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Connolly S.J., Ezekowitz M.D., Yusuf S. et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009;361(12):1139–51.</mixed-citation><mixed-citation xml:lang="ru">Connolly S.J., Ezekowitz M.D., Yusuf S. et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009;361(12):1139–51.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Patel M.R., Mahaffey K.W., Garg J. et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011;365(10):883–91.</mixed-citation><mixed-citation xml:lang="ru">Patel M.R., Mahaffey K.W., Garg J. et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011;365(10):883–91.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Connolly S.J., Eikelboom J., Joyner C. et al. Apixaban in patients with atrial fibrillation. N Engl J Med 2011;364(9):806–17.</mixed-citation><mixed-citation xml:lang="ru">Connolly S.J., Eikelboom J., Joyner C. et al. Apixaban in patients with atrial fibrillation. N Engl J Med 2011;364(9):806–17.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Giugliano R.P., Ruff C.T., Braunwald E. et al. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2013;369(22):2093–104.</mixed-citation><mixed-citation xml:lang="ru">Giugliano R.P., Ruff C.T., Braunwald E. et al. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2013;369(22):2093–104.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. Hughes M., Lip G.Y., Guideline Development Group et al. Stroke and thromboembolism in atrial fibrillation: a systematic review of stroke risk factors, risk stratification schema and cost effectiveness data. Tromb Haemost 2008;99(2):295–304.</mixed-citation><mixed-citation xml:lang="ru">Hughes M., Lip G.Y., Guideline Development Group et al. Stroke and thromboembolism in atrial fibrillation: a systematic review of stroke risk factors, risk stratification schema and cost effectiveness data. Tromb Haemost 2008;99(2):295–304.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">24. Stroke Risk in Atrial Fibrillation Working Group. Independent predictors of stroke in patients with atrial fibrillation: a systematic review. Neurology 2007;69(6):546–54.</mixed-citation><mixed-citation xml:lang="ru">Stroke Risk in Atrial Fibrillation Working Group. Independent predictors of stroke in patients with atrial fibrillation: a systematic review. Neurology 2007;69(6):546–54.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">25. Gage B.F., Waterman A.D., Shannon W. et al. Validation of clinical classification schemes for predicting stroke: results from the National registry of atrial fibrillation. JAMA 2001;285(22):2864–70.</mixed-citation><mixed-citation xml:lang="ru">Gage B.F., Waterman A.D., Shannon W. et al. Validation of clinical classification schemes for predicting stroke: results from the National registry of atrial fibrillation. JAMA 2001;285(22):2864–70.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">26. Lip G.Y., Nieuwlaat R., Pisters R. et al. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. Chest 2010;137(2):263–72.</mixed-citation><mixed-citation xml:lang="ru">Lip G.Y., Nieuwlaat R., Pisters R. et al. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. Chest 2010;137(2):263–72.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">27. Pisters R., Lane D.A., Nieuwlaat R. et al. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey on atrial fibrillation. Chest 2010;138(5):1093–100.</mixed-citation><mixed-citation xml:lang="ru">Pisters R., Lane D.A., Nieuwlaat R. et al. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey on atrial fibrillation. Chest 2010;138(5):1093–100.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">28. Ebright J., Mousa S.A. Oral anticoagulants and status of antidotes for the reversal of bleeding risk. Clin Appl Тhromb Hemost 2015;21(2):105–14.</mixed-citation><mixed-citation xml:lang="ru">Ebright J., Mousa S.A. Oral anticoagulants and status of antidotes for the reversal of bleeding risk. Clin Appl Тhromb Hemost 2015;21(2):105–14.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">29. Gomes T., Mamdani M.M., Holbrook A.M. et al. Rates of hemorrhage during warfarin therapy for atrial fibrillation. CMAJ 2013;185(2):E121–7.</mixed-citation><mixed-citation xml:lang="ru">Gomes T., Mamdani M.M., Holbrook A.M. et al. Rates of hemorrhage during warfarin therapy for atrial fibrillation. CMAJ 2013;185(2):E121–7.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">30. Hylek E.M., Evans-Molina C., Shea C. et al. Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation. Circulation 2007;115(21):2689–96.</mixed-citation><mixed-citation xml:lang="ru">Hylek E.M., Evans-Molina C., Shea C. et al. Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation. Circulation 2007;115(21):2689–96.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">31. Camm J.A., Colombo A., Corbucci G., Padeletti L. Left atrial appendage closure: a new technique for clinical practice. Heart Rhythm 2014;11(3):514–21.</mixed-citation><mixed-citation xml:lang="ru">Camm J.A., Colombo A., Corbucci G., Padeletti L. Left atrial appendage closure: a new technique for clinical practice. Heart Rhythm 2014;11(3):514–21.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">32. Давтян К.В., Ткачева О.Н., Калемберг А.А., Корецкий С.Н. Первый опыт имплантации окклюзирующих устройств в ушко левого предсердия с целью профилактики инсультов в Государственном научно-исследовательском центре профилактической медицины. Рациональная фармакотерапия в кардиологии 2014;10(3):307–11. [Davtyan K.V., Tkachyova O.N., Kalemberg A.A., Koretskiy S.N. First experience of implantation of occluding devices into the left atrial appendage to prevent strokes in the state research center of preventive medicine. Ratsionalnaya farmakoterapiya v kardiologii = Rational pharmacotherapy in cardiology 2014;10(3):307–11. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Давтян К.В., Ткачева О.Н., Калемберг А.А., Корецкий С.Н. Первый опыт имплантации окклюзирующих устройств в ушко левого предсердия с целью профилактики инсультов в Государственном научно-исследовательском центре профилактической медицины. Рациональная фармакотерапия в кардиологии 2014;10(3):307–11. [Davtyan K.V., Tkachyova O.N., Kalemberg A.A., Koretskiy S.N. First experience of implantation of occluding devices into the left atrial appendage to prevent strokes in the state research center of preventive medicine. Ratsionalnaya farmakoterapiya v kardiologii = Rational pharmacotherapy in cardiology 2014;10(3):307–11. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">33. Марцевич С.Ю., Воронина В.П., Дроздова Л.Ю. Здоровье и образование врача: две составляющие успеха. Рациональная фармакотерапия в кардиологии 2010;6(1):73–6. [Martsevich S.Y., Voronina V.P., Drozdova L.Y. Health and education of a doctor: Two components of success. Ratsionalnaya farmakoterapiya v kardiologii = Rational pharmacotherapy in cardiology 2010;6(1):73–6. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Марцевич С.Ю., Воронина В.П., Дроздова Л.Ю. Здоровье и образование врача: две составляющие успеха. Рациональная фармакотерапия в кардиологии 2010;6(1):73–6. [Martsevich S.Y., Voronina V.P., Drozdova L.Y. Health and education of a doctor: Two components of success. Ratsionalnaya farmakoterapiya v kardiologii = Rational pharmacotherapy in cardiology 2010;6(1):73–6. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">34. Dorian P., Kongnakorn T., Phatak H. et al. Cost-effectiveness of apixaban vs. current standard of care for stroke prevention in patients with atrial fibrillation. Eur Heart J 2014;35(28):1897–906.</mixed-citation><mixed-citation xml:lang="ru">Dorian P., Kongnakorn T., Phatak H. et al. Cost-effectiveness of apixaban vs. current standard of care for stroke prevention in patients with atrial fibrillation. Eur Heart J 2014;35(28):1897–906.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">35. Белоусов Ю.Б., Явелов И.С., Белоусов Д.Ю., Афанасьева Е.В. Анализ прямых затрат, ассоциированных с применением варфарина у пациентов с фибрилляцией предсердий. Рациональная фармакотерапия в кардиологии 2011;7(5):561–6. [Belousov Y.B., Yavelov I.S., Belousov D.Y., Afanasiyeva E.V. Analysis of direct costs associated with application of warfarin of patients with atrial fibrillation. Ratsionalnaya farmakoterapiya v kardiologii = Rational pharmacotherapy in cardiology 2011;7(5):561–6. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Белоусов Ю.Б., Явелов И.С., Белоусов Д.Ю., Афанасьева Е.В. Анализ прямых затрат, ассоциированных с применением варфарина у пациентов с фибрилляцией предсердий. Рациональная фармакотерапия в кардиологии 2011;7(5):561–6. [Belousov Y.B., Yavelov I.S., Belousov D.Y., Afanasiyeva E.V. Analysis of direct costs associated with application of warfarin of patients with atrial fibrillation. Ratsionalnaya farmakoterapiya v kardiologii = Rational pharmacotherapy in cardiology 2011;7(5):561–6. (In Russ.)].</mixed-citation></citation-alternatives></ref></ref-list></back></article>
