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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">The Clinician</journal-id><journal-title-group><journal-title xml:lang="en">The Clinician</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиницист</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8338</issn><issn publication-format="electronic">2412-8775</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">191</article-id><article-id pub-id-type="doi">10.17650/1818-8338-2015-9-2-23-27</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">METABOLIC DISTURBANCES IN THE FUTURE DEVELOPMENT AND PROGRESSION OF ARTERIAL HYPERTENSION IN YOUNG MEN</article-title><trans-title-group xml:lang="ru"><trans-title>МЕТАБОЛИЧЕСКИЕ НАРУШЕНИЯ В ПЕРСПЕКТИВЕ РАЗВИТИЯ И ПРОГРЕССИРОВАНИЯ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ У МОЛОДЫХ МУЖЧИН</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gordienko</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Гордиенко</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mirokhina</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Мирохина</surname><given-names>М. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dydyshko</surname><given-names>V. T.</given-names></name><name xml:lang="ru"><surname>Дыдышко</surname><given-names>В. Т.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Serdyukov</surname><given-names>D. Yu.</given-names></name><name xml:lang="ru"><surname>Сердюков</surname><given-names>Д. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>serdukovdu@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fedorova</surname><given-names>A. S.</given-names></name><name xml:lang="ru"><surname>Фёдорова</surname><given-names>А. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">S.M. Kirov Military Medical Academy, Ministry of Defense of Russia</institution></aff><aff><institution xml:lang="ru">ФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» Минобороны России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">6 Academician Lebedev St., Saint Petersburg, 194044, Russia</institution></aff><aff><institution xml:lang="ru">Россия, 194044, Санкт-Петербург, ул. Академика Лебедева, 6</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2015</year></pub-date><volume>9</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>23</fpage><lpage>27</lpage><history><date date-type="received" iso-8601-date="2015-08-13"><day>13</day><month>08</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-08-13"><day>13</day><month>08</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Gordienko A.V., Mirokhina M.A., Dydyshko V.T., Serdyukov D.Y., Fedorova A.S.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, Гордиенко А.В., Мирохина М.А., Дыдышко В.Т., Сердюков Д.Ю., Фёдорова А.С.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Gordienko A.V., Mirokhina M.A., Dydyshko V.T., Serdyukov D.Y., Fedorova A.S.</copyright-holder><copyright-holder xml:lang="ru">Гордиенко А.В., Мирохина М.А., Дыдышко В.Т., Сердюков Д.Ю., Фёдорова А.С.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://klinitsist.abvpress.ru/Klin/article/view/191">https://klinitsist.abvpress.ru/Klin/article/view/191</self-uri><abstract xml:lang="en"><p><bold><italic>Objective: </italic></bold><italic>to reveal carbohydrate and lipid metabolic disturbances and their possible importance in examined young men with early arterial hypertension (AH). </italic><bold><italic>Subjects and methods. </italic></bold><italic>A total of 130 men aged 40.3 ± 4.3 years were examined. There were 3 patient groups: stage I hypertensive disease with a history of AH (n = 61); primarily diagnosed hypertensive disease without evidence of long-term AH (n = 39); a control group noncardiovascular diseases (n = 30). </italic> <bold><italic>Results. </italic></bold><italic>The patients with long-term AH were more commonly found to have a compromised history of cardiovascular diseases and type 2 diabetes mellitus, signs of insulin resistance and subclinical atherosclerosis than those with the primarily diagnosed disease and the control group. </italic><bold><italic>Conclusion. </italic></bold><italic>Carbohydrate and lipid metabolic disturbances are latent in young men with long-term AH. Both 2and 1-hour oral glucose tolerance tests are recommended for the early diagnosis of glycemic disorders in the above patient cohort. </italic></p></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>arterial hypertension</kwd><kwd>hypertensive disease</kwd><kwd>early lipid and carbohydrate metabolic disorder</kwd><kwd>standard glucose tolerance test</kwd><kwd>postprandial glycemia</kwd><kwd>prediabetes</kwd><kwd>insulin resistance</kwd><kwd>dyslipidemia</kwd><kwd>apolipoproteins</kwd><kwd>subclinical atherosclerosis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>артериальная гипертензия, гипертоническая болезнь, раннее нарушение липидного и углеводного обмена, стандартный глюкозотолерантный тест, постпрандиальная гликемия, предиабет, инсулинорезистентность, дислипидемия, аполипопротеиды, субклинический атероск</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Литовский И.А., Гордиенко А.В., Смирнов А.А. Атеросклероз и гипертоническая болезнь: вопросы патогенеза, диагностики и лечения. СПб.: СпецЛит, 2012. [Litovskiy I.A., Gordienko A.V., Smirnov A.A. Atherosclerosis and hypertensive disease: issues of pathogenesis, diagnostics and management. Saint Petersburg: SpetsLit, 2012. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Литовский И.А., Гордиенко А.В., Смирнов А.А. Атеросклероз и гипертоническая болезнь: вопросы патогенеза, диагностики и лечения. СПб.: СпецЛит, 2012. [Litovskiy I.A., Gordienko A.V., Smirnov A.A. Atherosclerosis and hypertensive disease: issues of pathogenesis, diagnostics and management. Saint Petersburg: SpetsLit, 2012. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Маковеева О.В., Гордиенко А.В., Дыдышко В.Т. и др. Стратификация кардиоваскулярного риска у лиц молодого возраста, страдающих эссенциальной гипертензией. Вестник Российской военно-медицинской академии 2014;4(48): 58–61. [Makoveeva O.V., Gordienko A.V., Dydyshko V.T. et al. Stratification of cardiovascular risk in young patients with essential hypertension. Vestnik Rossiyskoy voenno-meditsinskoy akademii = Russian military medical academy herald 2014;4(48):58–61. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Маковеева О.В., Гордиенко А.В., Дыдышко В.Т. и др. Стратификация кардиоваскулярного риска у лиц молодого возраста, страдающих эссенциальной гипертензией. Вестник Российской военно-медицинской академии 2014;4(48): 58–61. [Makoveeva O.V., Gordienko A.V., Dydyshko V.T. et al. Stratification of cardiovascular risk in young patients with essential hypertension. Vestnik Rossiyskoy voenno-meditsinskoy akademii = Russian military medical academy herald 2014;4(48):58–61. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Bianchi C., Miccoli R., Trombetta M. et al. Elevated 1-hour postload plasma glucose levels identify subjects with normal glucose tolerance but impaired β-cell function, insulin resistance, and worse cardiovascular risk profile: the GENFIEV study. J Clin Endocrinol Metab 2013;98(5):2100–5.</mixed-citation><mixed-citation xml:lang="ru">Bianchi C., Miccoli R., Trombetta M. et al. Elevated 1-hour postload plasma glucose levels identify subjects with normal glucose tolerance but impaired β-cell function, insulin resistance, and worse cardiovascular risk profile: the GENFIEV study. J Clin Endocrinol Metab 2013;98(5):2100–5.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Zhang H., Thijs L., Kuznetsova T. et al. Progression to hypertension in the nonhypertensive participants in the Flemish Study on Environment, Genes and Health Outcomes. J Hypertens 2006;24(9):1719–27.</mixed-citation><mixed-citation xml:lang="ru">Zhang H., Thijs L., Kuznetsova T. et al. Progression to hypertension in the nonhypertensive participants in the Flemish Study on Environment, Genes and Health Outcomes. J Hypertens 2006;24(9):1719–27.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Sciacqua A., Maio R., Miceli S. et al. Association between one-hour post-load plasma glucose levels and vascular stiffness in essential hypertension. PLоS One 2012;7(9):e44470.</mixed-citation><mixed-citation xml:lang="ru">Sciacqua A., Maio R., Miceli S. et al. Association between one-hour post-load plasma glucose levels and vascular stiffness in essential hypertension. PLоS One 2012;7(9):e44470.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Mancia G., Fagard R., Narkiewicz K. et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2013;31(7):1281–357.</mixed-citation><mixed-citation xml:lang="ru">Mancia G., Fagard R., Narkiewicz K. et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2013;31(7):1281–357.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Рекомендации экспертов Всероссийского научного общества кардиологов по диагностике и лечению метаболического синдрома (2-й пересмотр). М.: ВНОК, 2009. [Recommendations of experts of Society of cardiology of Russian Federation for diagnostics and management of metabolic syndrome (2nd revision). Moscow: VNOK, 2009. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Рекомендации экспертов Всероссийского научного общества кардиологов по диагностике и лечению метаболического синдрома (2-й пересмотр). М.: ВНОК, 2009. [Recommendations of experts of Society of cardiology of Russian Federation for diagnostics and management of metabolic syndrome (2nd revision). Moscow: VNOK, 2009. (In Russ.)].</mixed-citation></citation-alternatives></ref></ref-list></back></article>
