<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">The Clinician</journal-id><journal-title-group><journal-title xml:lang="en">The Clinician</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиницист</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8338</issn><issn publication-format="electronic">2412-8775</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">16</article-id><article-id pub-id-type="doi">10.17650/1818-8338-2013-3-4-80-86</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>PHARMACOTHERAPY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ФАРМАКОТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">HYPERTENSION IN POSTMENOPAUSAL WOMEN: POSSIBILITIES OF COMBINATION THERAPY</article-title><trans-title-group xml:lang="ru"><trans-title>АРТЕРИАЛЬНАЯ ГИПЕРТЕНЗИЯ У ЖЕНЩИН В ПОСТМЕНОПАУЗЕ – ВОЗМОЖНОСТИ КОМБИНИРОВАННОЙ ТЕРАПИИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shostak</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Шостак</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A.I. Nesterov Department of Faculty Therapy</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А. И. Нестерова</p></bio><email>nshostak44@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pravdyuk</surname><given-names>N. G.</given-names></name><name xml:lang="ru"><surname>Правдюк</surname><given-names>Н. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A.I. Nesterov Department of Faculty Therapy</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А. И. Нестерова</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Anichkov</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Аничков</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A.I. Nesterov Department of Faculty Therapy</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А. И. Нестерова</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kondrashov</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Кондрашов</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Acad. A.I. Nesterov Department of Faculty Therapy</p></bio><bio xml:lang="ru"><p>Кафедра факультетской терапии им. акад. А. И. Нестерова</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО РНИМУ им. Н. И. Пирогова Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2013</year></pub-date><volume>7</volume><issue>3-4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>80</fpage><lpage>86</lpage><history><date date-type="received" iso-8601-date="2014-07-14"><day>14</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-14"><day>14</day><month>07</month><year>2014</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Shostak N.A., Pravdyuk N.G., Anichkov D.A., Kondrashov A.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, Шостак Н.А., Правдюк Н.Г., Аничков Д.А., Кондрашов А.А.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Shostak N.A., Pravdyuk N.G., Anichkov D.A., Kondrashov A.A.</copyright-holder><copyright-holder xml:lang="ru">Шостак Н.А., Правдюк Н.Г., Аничков Д.А., Кондрашов А.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://klinitsist.abvpress.ru/Klin/article/view/16">https://klinitsist.abvpress.ru/Klin/article/view/16</self-uri><abstract xml:lang="en"><p><bold>Objective</bold> – to study the efficacy and safety of Tenoten in the combination therapy of hypertension in early postmenopausal women.</p><p><bold>Subjects and methods</bold>. The study enrolled 60 early postmenopausal women with grade I–II hypertension. A study group included 30 women who took Tenoten during antihypertensive therapy (AHT); a control group comprised 30 women who received AHT only.</p><p><bold>Results.</bold> Tenoten could achieve additional improvement of 24-hour blood pressure (BP) monitoring data in the postmenopausal hypertensive women. Tenoten was found to have a positive effect on general health, activity, and mood and to alleviate the symptoms of autonomic dysfunction and anxiety.</p><p><bold>Conclusion.</bold> Tenoten that is able to alleviate the manifestations of anxiety and autonomic dysfunction, to exert a positive effect on bloodpressure values, and to improves health, mood, and social activity should be used in addition to AGT.</p></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>hypertension</kwd><kwd>postmenopause</kwd><kwd>postmenopausal syndrome</kwd><kwd>anxiety</kwd><kwd>autonomic disorders</kwd><kwd>psychoemotional disorders</kwd><kwd>Tenoten</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>постменопауза</kwd><kwd>климактерический синдром</kwd><kwd>тревога</kwd><kwd>вегетативные расстройства</kwd><kwd>психоэмоциональные расстройства</kwd><kwd>Тенотен</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Chae C.U., Derby C.A. The menopausal transition and cardiovascular risk. Obstet Gynecol Clin North Am 2011;38(3):477–88.</mixed-citation><mixed-citation xml:lang="ru">Chae C.U., Derby C.A. The menopausal transition and cardiovascular risk. Obstet Gynecol Clin North Am 2011;38(3):477–88.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Аничков Д.А., Шостак Н.А, Журавлева А.Д. Менопауза и сердечно-сосудистый риск. Рационал фармакотер в кардиол 2005;1(1):37–42.</mixed-citation><mixed-citation xml:lang="ru">Аничков Д.А., Шостак Н.А, Журавлева А.Д. Менопауза и сердечно-сосудистый риск. Рационал фармакотер в кардиол 2005;1(1):37–42.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Lima R., Wofford M., Reckelhoff J.F. Hypertension in postmenopausal women. Curr Hypertens Rep 2012;14(3):254–60.</mixed-citation><mixed-citation xml:lang="ru">Lima R., Wofford M., Reckelhoff J.F. Hypertension in postmenopausal women. Curr Hypertens Rep 2012;14(3):254–60.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Подзолков В.И., Можарова Л.Г., Хомицкая Ю.В. Артериальная гипертензия у женщин с климактерическим синдромом. Обзоры клин кардиол 2005;(1):12–9.</mixed-citation><mixed-citation xml:lang="ru">Подзолков В.И., Можарова Л.Г., Хомицкая Ю.В. Артериальная гипертензия у женщин с климактерическим синдромом. Обзоры клин кардиол 2005;(1):12–9.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Шостак Н.А., Аничков Д.А. Эффективность моксонидина у женщин с артериальной гипертензией в рамках метаболического синдрома при исходновысокой частоте сердечных сокращений.</mixed-citation><mixed-citation xml:lang="ru">Шостак Н.А., Аничков Д.А. Эффективность моксонидина у женщин с артериальной гипертензией в рамках метаболического синдрома при исходновысокой частоте сердечных сокращений.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><mixed-citation>Кардиология 2002;42(11):40–3.</mixed-citation></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">6. 2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH/ESC Task Force for the Management of Arterial Hypertension. J Hypertens 2013;31(10):1925–38.</mixed-citation><mixed-citation xml:lang="ru">2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH/ESC Task Force for the Management of Arterial Hypertension. J Hypertens 2013;31(10):1925–38.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">7. Национальные клинические рекомендации: Сборник. Под ред. Р.Г. Оганова. 3-е изд. М.: Силицея-Полиграф, 2010. 592 с.</mixed-citation><mixed-citation xml:lang="ru">Национальные клинические рекомендации: Сборник. Под ред. Р.Г. Оганова. 3-е изд. М.: Силицея-Полиграф, 2010. 592 с.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">8. Ванчакова Н.П., Попов А.П. Тревожные расстройства у пациентов с гипертонической болезнью и ишемической болезнью сердца и опыт их коррекции Тенотеном. Поликлиника 2007;(2):74–8.</mixed-citation><mixed-citation xml:lang="ru">Ванчакова Н.П., Попов А.П. Тревожные расстройства у пациентов с гипертонической болезнью и ишемической болезнью сердца и опыт их коррекции Тенотеном. Поликлиника 2007;(2):74–8.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">9. Никольская И.Н., Гусева И.А., Близневская Е.В., Третьякова Т.В. Роль тревожных расстройств при гипертонической болезни и возможности их коррекции. Лечащий врач 2007;(3):89–90.</mixed-citation><mixed-citation xml:lang="ru">Никольская И.Н., Гусева И.А., Близневская Е.В., Третьякова Т.В. Роль тревожных расстройств при гипертонической болезни и возможности их коррекции. Лечащий врач 2007;(3):89–90.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">10. Доскин В.А., Лаврентьев Н.А., Мирошников М.П., Шарай В.Б. Тест дифференцированной самооценки функционального состояния. Вопр психол 1973;(6):141–6.</mixed-citation><mixed-citation xml:lang="ru">Доскин В.А., Лаврентьев Н.А., Мирошников М.П., Шарай В.Б. Тест дифференцированной самооценки функционального состояния. Вопр психол 1973;(6):141–6.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">11. Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol 1959;32(1):50–5.</mixed-citation><mixed-citation xml:lang="ru">Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol 1959;32(1):50–5.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
