<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">The Clinician</journal-id><journal-title-group><journal-title xml:lang="en">The Clinician</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиницист</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8338</issn><issn publication-format="electronic">2412-8775</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">154</article-id><article-id pub-id-type="doi">10.17650/1818-8338-2014-8-1-</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>PHARMACOTHERAPY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ФАРМАКОТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">SPINAL PAIN SYNDROME: DEVELOPMENT MECHANISMS AND APPROACHES TO COMBINATION THERAPY</article-title><trans-title-group xml:lang="ru"><trans-title>БОЛЕВОЙ СИНДРОМ В СПИНЕ: МЕХАНИЗМЫ РАЗВИТИЯ И ПОДХОДЫ К КОМПЛЕКСНОЙ ТЕРАПИИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Martynov</surname><given-names>M. Yu.</given-names></name><name xml:lang="ru"><surname>Мартынов</surname><given-names>М. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>m-martin@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава России, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2014</year></pub-date><volume>8</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>87</fpage><lpage>90</lpage><history><date date-type="received" iso-8601-date="2014-11-23"><day>23</day><month>11</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-11-23"><day>23</day><month>11</month><year>2014</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Martynov M.Y.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, Мартынов М.Ю.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Martynov M.Y.</copyright-holder><copyright-holder xml:lang="ru">Мартынов М.Ю.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://klinitsist.abvpress.ru/Klin/article/view/154">https://klinitsist.abvpress.ru/Klin/article/view/154</self-uri><abstract xml:lang="en"><p>The paper considers an association between spinal pain syndrome and the magnitude of vertebral column changes in osteochondrosis and the specific features and characteristics of pain syndrome. It gives the data that allow the consideration of spinal osteochondrosis as a degenerative and dystrophic process that is concurrent with the compensatory rearrangement of a vertebral motor segment, chiefly a disk, and aimed at adapting the functional capacities of the vertebral column as a whole. The issues of therapy for spinal pain syndrome with a combination of nonsteroidal anti-inflammatory drugs and a vitamin B (B1, B6, and B12) complex are covered.</p></abstract><trans-abstract xml:lang="ru"><p>В статье рассмотрены вопросы связи между болевым синдромом в спине и выраженностью изменений позвоночника при остеохондрозе, а также особенности и характеристики болевого синдрома. Представлены данные, позволяющие рассматривать остеохондроз позвоночника как дегенеративно-дистрофический процесс, сочетающийся с компенсаторной перестройкой позвоночно-двигательного сегмента, прежде всего диска, и направленный на адаптацию функциональных возможностей позвоночного столба в целом. Освещены вопросы терапии болевого синдрома в спине комбинированным назначением нестероидных проти-вовоспалительных препаратов и комплекса витаминов группы В (В1, В6 и В12).</p></trans-abstract><kwd-group xml:lang="en"><kwd>spinal pain</kwd><kwd>osteochondrosis</kwd><kwd>nonsteroidal anti-inflammatory drugs</kwd><kwd>vitamin B group</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>боль в спине</kwd><kwd>остеохондроз</kwd><kwd>нестероидные противовоспалительные препараты</kwd><kwd>витамины группы В</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Manchikanti L., Singh V., Datta S. et al. Comprehensive review of epidemiology, scope, and impact of spinal pain. Pain Physician 2009;12(4):E35–70.</mixed-citation><mixed-citation xml:lang="ru">Manchikanti L., Singh V., Datta S. et al. Comprehensive review of epidemiology, scope, and impact of spinal pain. Pain Physician 2009;12(4):E35–70.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Pengel L.Н., Herbert R.D., Maher C.G., Refshauge K.M. Acute low back pain: systematic review of its prognosis. BMJ 2003;327(7410):323.</mixed-citation><mixed-citation xml:lang="ru">Pengel L.Н., Herbert R.D., Maher C.G., Refshauge K.M. Acute low back pain: systematic review of its prognosis. BMJ 2003;327(7410):323.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Веселовский В.П. Практическая вертеброневрология и мануальная терапия. Рига, 1991.</mixed-citation><mixed-citation xml:lang="ru">Веселовский В.П. Практическая вертеброневрология и мануальная терапия. Рига, 1991.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Болевые синдромы в неврологической практике. Под ред. В.Л. Голубева. М.: МЕДпресс-информ, 2010.</mixed-citation><mixed-citation xml:lang="ru">Болевые синдромы в неврологической практике. Под ред. В.Л. Голубева. М.: МЕДпресс-информ, 2010.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Иваничев Г.А. Мануальная медицина. Казань, 2000.</mixed-citation><mixed-citation xml:lang="ru">Иваничев Г.А. Мануальная медицина. Казань, 2000.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Jensen M.P., Dworkin R.H., Gammaitoni A.R. et al. Assessment of pain quality in chronic neuropathic and nociceptive pain clinical trials with the Neuropathic Pain Scale. J Pain 2005;6(2):98–106.</mixed-citation><mixed-citation xml:lang="ru">Jensen M.P., Dworkin R.H., Gammaitoni A.R. et al. Assessment of pain quality in chronic neuropathic and nociceptive pain clinical trials with the Neuropathic Pain Scale. J Pain 2005;6(2):98–106.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Попелянский Я.Ю., Штульман Д.Р. Боли в шее, спине и конечностях. В кн.: Болезни нервной системы. Под ред. Н.Н. Яхно, Д.Р. Штульмана. М.: Медицина, 2001. С. 293–316.</mixed-citation><mixed-citation xml:lang="ru">Попелянский Я.Ю., Штульман Д.Р. Боли в шее, спине и конечностях. В кн.: Болезни нервной системы. Под ред. Н.Н. Яхно, Д.Р. Штульмана. М.: Медицина, 2001. С. 293–316.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. van Tulder M., Becker A., Bekkering T. et al. Chapter 3. European guidelines for the management of acute nonspecific low back pain in primary care. Eur Spine J 2006; 15 Suppl 2:S169–91.</mixed-citation><mixed-citation xml:lang="ru">van Tulder M., Becker A., Bekkering T. et al. Chapter 3. European guidelines for the management of acute nonspecific low back pain in primary care. Eur Spine J 2006; 15 Suppl 2:S169–91.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Vining R., Potocki E., Seidman M., Morgenthal A.P. An evidence-based diagnostic classification system for low back pain. J Can Chiropr Assoc 2013;57(3):189–204.</mixed-citation><mixed-citation xml:lang="ru">Vining R., Potocki E., Seidman M., Morgenthal A.P. An evidence-based diagnostic classification system for low back pain. J Can Chiropr Assoc 2013;57(3):189–204.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Данилов А.Б. Алгоритм диагностики и лечения боли в нижней части спины с точки зрения доказательной медицины. Атмосфера. Нервные болезни 2010;(4): 11–8.</mixed-citation><mixed-citation xml:lang="ru">Данилов А.Б. Алгоритм диагностики и лечения боли в нижней части спины с точки зрения доказательной медицины. Атмосфера. Нервные болезни 2010;(4): 11–8.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Камчатнов П.Р. Применение препаратов Мильгамма и Мильгамма композитум у пациентов с болью в спине. Мед вестн 2010;(4–5):509–10.</mixed-citation><mixed-citation xml:lang="ru">Камчатнов П.Р. Применение препаратов Мильгамма и Мильгамма композитум у пациентов с болью в спине. Мед вестн 2010;(4–5):509–10.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Khan T.A., Ahmad A., Haider I.Z. Treatment of acute lumbago; low dose diclofenac sodium with vitamin-B complex compared with diclofenac alone. Professional Med J 2008;15(4):440–4.</mixed-citation><mixed-citation xml:lang="ru">Khan T.A., Ahmad A., Haider I.Z. Treatment of acute lumbago; low dose diclofenac sodium with vitamin-B complex compared with diclofenac alone. Professional Med J 2008;15(4):440–4.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Mauro G.L., Martorana U., Cataldo P. et al. Vitamin B12 in low back pain: a randomised, double-blind, placebocontrolled study. Eur Rev Med Pharmacol Sci 2000;4(3):53–8.</mixed-citation><mixed-citation xml:lang="ru">Mauro G.L., Martorana U., Cataldo P. et al. Vitamin B12 in low back pain: a randomised, double-blind, placebocontrolled study. Eur Rev Med Pharmacol Sci 2000;4(3):53–8.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Rocha-Gonzalez H.I., Teran-Rosales F., Reyes-Garcia G. et al. B vitamins increase the analgesic effect of diclofenac in the rat. Proc West Pharmacol Soc 2004;47:84–7.</mixed-citation><mixed-citation xml:lang="ru">Rocha-Gonzalez H.I., Teran-Rosales F., Reyes-Garcia G. et al. B vitamins increase the analgesic effect of diclofenac in the rat. Proc West Pharmacol Soc 2004;47:84–7.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Левин О.С., Мосейкин И.А. Комплекс витаминов группы В (Мильгамма) в лечении дискогенной поясничнокрестцовой радикулопатии. Журн неврол психиатр им. С.С. Корсакова 2009; 109(10):30–5.</mixed-citation><mixed-citation xml:lang="ru">Левин О.С., Мосейкин И.А. Комплекс витаминов группы В (Мильгамма) в лечении дискогенной поясничнокрестцовой радикулопатии. Журн неврол психиатр им. С.С. Корсакова 2009; 109(10):30–5.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Fu Q.G., Carstens E., Stelzer B., Zimmermann M. B vitamins suppress spinal dorsal horn nociceptive neurons in the cat. Neurosci Lett 1988;95(1–3):192–7.</mixed-citation><mixed-citation xml:lang="ru">Fu Q.G., Carstens E., Stelzer B., Zimmermann M. B vitamins suppress spinal dorsal horn nociceptive neurons in the cat. Neurosci Lett 1988;95(1–3):192–7.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Bromm K., Herrmann W.M., Schulz H. Do the B vitamins exhibit antinociceptive efficacy in men? Results of a placebocontrolled study. Neuropsychobiology 1995;31(3):156–65.</mixed-citation><mixed-citation xml:lang="ru">Bromm K., Herrmann W.M., Schulz H. Do the B vitamins exhibit antinociceptive efficacy in men? Results of a placebocontrolled study. Neuropsychobiology 1995;31(3):156–65.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Bartoszyk G.D., Wild A. B-vitamins potentiate the antinociceptive effect of diclofenac in carrageenin-induced hyperalgesia in the rat tail pressure test. Neurosci Lett 1989;101(1):95–100.</mixed-citation><mixed-citation xml:lang="ru">Bartoszyk G.D., Wild A. B-vitamins potentiate the antinociceptive effect of diclofenac in carrageenin-induced hyperalgesia in the rat tail pressure test. Neurosci Lett 1989;101(1):95–100.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
