The ClinicianThe ClinicianКлиницист1818-83382412-8775Publishing House ABV Press14210.17650/1818-8338-2014-1-15-21REVIEWОБЗОРCARDIOVASCULAR RISK FACTORS IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROMEФАКТОРЫ РИСКА СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙ У БОЛЬНЫХ С СИНДРОМОМ ОБСТРУКТИВНОГО АПНОЭ СНАMarkinA. V.МаркинА. В.
Russian Federation
sibirson@gmail.comMartynenkoT. I.МартыненкоТ. И.
Russian Federation
KostyuchenkoG. I.КостюченкоГ. И.
Russian Federation
TseimakhI. Ya.ЦеймахИ. Я.
Russian Federation
ShoikhetYa. N.ШойхетЯ. Н.
Russian Federation
Altai State Medical University, Ministry of Health of Russia, Barnaul City Hospital Five, BarnaulГБОУ ВПО «Алтайский государственный медицинский университет» Минздрава России, Барнаул КГБУЗ «Городская больница № 5», БарнаулCity Hospital Five, BarnaulКГБУЗ «Городская больница № 5», БарнаулRegional Clinical Hospital, BarnaulКГБУЗ «Краевая клиническая больница», БарнаулAltai State Medical University, Ministry of Health of Russia, BarnaulГБОУ ВПО «Алтайский государственный медицинский университет» Минздрава России, Барнаул150120148115212311201423112014Copyright ©; 2014, Markin A.V., Martynenko T.I., Kostyuchenko G.I., Tseimakh I.Y., Shoikhet Y.N.Copyright ©; 2014, Маркин А.В., Мартыненко Т.И., Костюченко Г.И., Цеймах И.Я., Шойхет Я.Н.2014Markin A.V., Martynenko T.I., Kostyuchenko G.I., Tseimakh I.Y., Shoikhet Y.N.Маркин А.В., Мартыненко Т.И., Костюченко Г.И., Цеймах И.Я., Шойхет Я.Н.https://creativecommons.org/licenses/by/4.0https://klinitsist.abvpress.ru/Klin/article/view/142

The paper analyzes the cause-and-effect relations of obstructive sleep apnea syndrome (OSAS) and cardiovascular diseases (CVD). In OSAS,there is activation of the sympathetic nervous system and proinflammatory and procoagulant systems, endothelial dysfunction, and accelerated atherosclerosis in response to intermittent hypoxia and sleep fragmentation, which leads to increased risk for CVD. Continuous positive airway pressure therapy reduces the risk of death in patients with OSAS

В статье анализируются причинно-следственные связи синдрома обструктивного апноэ сна (СОАС) и сердечно-сосудистых заболеваний (ССЗ). При СОАС в ответ на интермиттирующую гипоксию и фрагментацию сна происходит активация симпатической нервной системы, провоспалительной и прокоагуляционных систем, эндотелиальная дисфункция и ускоренное развитие атеросклероза, что приводит к увеличению риска ССЗ. Применение CPAP-терапии (Continuous Positive Airway Pressure – постоянное положительное давление в дыхательных путях) снижает риск смерти у больных СОАС.

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