The ClinicianThe ClinicianКлиницист1818-83382412-8775Publishing House ABV Press12710.17650/1818-8338-2011-2-86-93PHARMACOTHERAPYФАРМАКОТЕРАПИЯCALCIFIC AORTIC STENOSIS AND OSTEOPOROSIS: GENERAL MECHANISMS AND PERSPECTIVES OF PHARMACOLOGICAL CORRECTIONКАЛЬЦИНИРОВАННЫЙ АОРТАЛЬНЫЙ СТЕНОЗ И ОСТЕОПОРОЗ: ОБЩИЕ МЕХАНИЗМЫ И ПЕРСПЕКТИВЫ ФАРМАКОЛОГИЧЕСКОЙ КОРРЕКЦИИKarpovaN. Yu.КарповаН. Ю.
Russian Federation

Acad. A.I. Nesterov’s Therapy Department

Кафедра факультетской терапии им. акад. А.И. Нестерова

RashydM. A.РашидМ. А.
Russian Federation
ShostakN. A.ШостакН. А.
Russian Federation

Acad. A.I. Nesterov’s Therapy Department

Кафедра факультетской терапии им. акад. А.И. Нестерова

KazakovaT. V.КазаковаТ. в
Russian Federation

Acad. A.I. Nesterov’s Therapy Department

Кафедра факультетской терапии им. акад. А.И. Нестерова

Russian State Medical University, Ministry of Health and Social Development of RussiaГОУ ВПО РГМУ Минздравсоцразвития РоссииCity Clinical Hospital № 55, MoscowГородская клиническая больница № 55150420115286931707201417072014Copyright ©; 2011, Karpova N.Y., Rashyd M.A., Shostak N.A., Kazakova T.V.Copyright ©; 2011, Карпова Н.Ю., Рашид М.А., Шостак Н.А., Казакова Т.в.2011Karpova N.Y., Rashyd M.A., Shostak N.A., Kazakova T.V.Карпова Н.Ю., Рашид М.А., Шостак Н.А., Казакова Т.в.https://creativecommons.org/licenses/by/4.0https://klinitsist.abvpress.ru/Klin/article/view/127

The article discusses many common clinical and laboratory features of calcific aortic stenosis (CAS) and osteoporosis in patients of advanced age. After evaluation of bone mineral density, risk factors of fractures and falls, in conjunction with bone turnover markers, 2 distinct types of osteoporosis in CAS patients were described. The active character of bone’s turnover and aortic valve calcification can not regard CAS as degenerative, but regenerative process. The article is illustrated by case history, and elucidates the possibilities of pharmacological intervention, including new bisphosphonate drug – xydiphone.

В статье обсуждаются общие клинические и лабораторные признаки кальцинированного аортального стеноза (КАС) и остеопороза у лиц пожилого возраста. Изучение минеральной плотности костной ткани, факторов риска падений и патологических переломов в сочетании с определением маркеров костного ремоделирования позволило описать 2 вида остеопороза у больных КАС. Активный характер костного обмена и кальцификации клапана аорты позволяют считать КАС регенеративным, а не дегенеративным процессом. Представлено собственное клиническое наблюдение и освещены возможности осуществления фармакологической коррекции заболевания, в том числе с применением нового препарата из класса бисфосфанатов – ксидифона.

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