The ClinicianThe ClinicianКлиницист1818-83382412-8775Publishing House ABV Press12110.17650/1818-8338-2011-2-52-56ORIGINAL INVESTIGATIONSОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕBRONCHOPULMONARY LESIONS AND QUALITY OF LIFE IN PATIENTS WITH RHEUMATOID ARTHRITISБРОНХОЛЕГОЧНЫЕ ПОРАЖЕНИЯ И КАЧЕСТВО ЖИЗНИ БОЛЬНЫХ РЕВМАТОИДНЫМ АРТРИТОМSheyanovM. V.ШеяновМ. В.
Russian Federation

Faculty Therapy Department №1, Medical Faculty

Кафедра факультетской терапии № 1 лечебного факультета

msheyanov@mail.ruSchedrinaI. S.ЩедринаИ. С.
Russian Federation

Vinogradov Faculty Therapy Clinic

Факультетская терапевтическая клиника им. В.Н. Виноградова

SulimovV. A.СулимовВ. А.
Russian Federation

Faculty Therapy Department №1, Medical Faculty

Кафедра факультетской терапии № 1 лечебного факультета

I.M. Sechenov First Moscow State Medical University1-ый МГМУ им. И.М. Сеченова150420115252561707201417072014Copyright ©; 2011, Sheyanov M.V., Schedrina I.S., Sulimov V.A.Copyright ©; 2011, Шеянов М.В., Щедрина И.С., Сулимов В.А.2011Sheyanov M.V., Schedrina I.S., Sulimov V.A.Шеянов М.В., Щедрина И.С., Сулимов В.А.https://creativecommons.org/licenses/by/4.0https://klinitsist.abvpress.ru/Klin/article/view/121

Aim – assessment of quality of life (QoL) in patients with rheumatoid arthritis (RA) with the presence and severity of bronchopulmonary lesions.

Materials and methods. The study included 104 patients with RA and 100 patients not suffering from RA and verified chronic respiratory diseases. The analysis of the QOL of patients using questionnaires EQ-5D (EuroQoL Group, 1990) and SGRQ (St. George's Hospital questionnaire to assess respiratory function), performed spirometry, bodyplethysmography , pulse oximetry, the definition of lung diffusioncapacity, multispiral computed tomography of the lungs.

Results. Performance of all scales and the resulting indices of questionnaires EQ-5D and SGRQ showed a significant decrease in QoL ofRA patients compared with those in control group and the general population. A correlation index of EQ-5D with vital capacity (r = 0.47;p < 0.001) and diffusion capacity (r = 0.67; p < 0.01) of the lungs is revealed. The main reason for the reduction of indices of the questionnaire SGRQ in patients with RA was the presence of shortness of breath. The multi-factorial origin of dyspnea in patients with RA with theessential role of bronchopulmonary lesions was established.

Conclusion. Bronchopulmonary lesions in the underlying disease have an adverse impact on the QOL of patients with RA. Promising directions for improving the QOL of RA patients with bronchial lesions can be considered for activities for the conservation of respiratory lung function, exercise control RA activity, elimination of anemia correction of psycho-emotional disturbances of anxiety-depressive character.

rheumatoid arthritislung damagequality of lifeревматоидный артритпоражение легкихкачество жизни1. Амирджанова В.Н. Ревматоидный артрит с позиций оценки качества жизни больных. Терапевтический архив 2007;(5):9–15.Амирджанова В.Н. Ревматоидный артрит с позиций оценки качества жизни больных. Терапевтический архив 2007;(5):9–15.2. Brooks P., Boers M., Simon L., et al. Outcome measures in rheumatoid arthritis –the OMERACT process. Expert Rev Clin Immunol 2007;3:271–5.Brooks P., Boers M., Simon L., et al. Outcome measures in rheumatoid arthritis –the OMERACT process. Expert Rev Clin Immunol 2007;3:271–5.3. Linde L., Sorensen J., Ostergaard M., et al. Health-related quality of life: validity, reliability, and responsiveness of SF-36, EQ-15D, EQ-5D, RAQoL, and HAQ in patients with rheumatoid arthritis. J Rheumatol 2008;35:1528–37.Linde L., Sorensen J., Ostergaard M., et al. Health-related quality of life: validity, reliability, and responsiveness of SF-36, EQ-15D, EQ-5D, RAQoL, and HAQ in patients with rheumatoid arthritis. J Rheumatol 2008;35:1528–37.4. Gabriel S.E., Crowson C., Kremers H., et al. Survival in rheumatoid arthritis: a populationbasedGabriel S.E., Crowson C., Kremers H., et al. Survival in rheumatoid arthritis: a populationbasedanalysis of trends over 40 years. Arthritis Rheum 2003;48:54–8.5. Swinson D.R., Symmons D., Suresh U., et al. Decreased survival in patients with co-existentSwinson D.R., Symmons D., Suresh U., et al. Decreased survival in patients with co-existentrheumatoid arthritis and bronchiectasis. Br J Rheumatol 1997;36:689–91.6. Turesson C., Matteson E. Management of extra-articular disease manifestations in rheumatoid arthritis. Curr Opin Rheumatol 2004;16:206–11.Turesson C., Matteson E. Management of extra-articular disease manifestations in rheumatoid arthritis. Curr Opin Rheumatol 2004;16:206–11.7. Crestani B. The respiratory system in connective tissue disorders. Allergy 2005;60:715–34.Crestani B. The respiratory system in connective tissue disorders. Allergy 2005;60:715–34.8. Brown K. Rheumatoid lung disease. Proc Am Thorac Soc 2007;4:443–8.Brown K. Rheumatoid lung disease. Proc Am Thorac Soc 2007;4:443–8.9. Шеянов М.В., Терновой С.К., Фоминых Е.В. и др. Поражения легких и нижних дыхательных путей у больных ревматоидным артритом. Клиническая медицина 2010;(2):46–50.Шеянов М.В., Терновой С.К., Фоминых Е.В. и др. Поражения легких и нижних дыхательных путей у больных ревматоидным артритом. Клиническая медицина 2010;(2):46–50.10. Arnett F., Edworthy S., Bloch D., et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315–24.Arnett F., Edworthy S., Bloch D., et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315–24.11. EuroQol – a new facility for the measurement of health-related quality of life. Health PolicyEuroQol – a new facility for the measurement of health-related quality of life. Health Policy1990;16:199–208.;16:199–208.12. Jones P.W., Quirk F.H., Baveystock C.M. The St George's Respiratory Questionnaire. RespirJones P.W., Quirk F.H., Baveystock C.M. The St George's Respiratory Questionnaire. RespirMed 1991;85(Suppl B):25–31.13. Beretta L., Santaniello A., Lemos A., et al. Validity of the Saint George's Respiratory Questionnaire in the evaluation of the healthrelated quality of life in patients with interstitial lung disease secondary to systemic sclerosis. Rheumatology 2007;46:296–301.Beretta L., Santaniello A., Lemos A., et al. Validity of the Saint George's Respiratory Questionnaire in the evaluation of the healthrelated quality of life in patients with interstitial lung disease secondary to systemic sclerosis. Rheumatology 2007;46:296–301.14. Ferrer M., Villasante C., Alonso J., et al. Interpretation of quality of life scores from the St George's Respiratory Questionnaire. Eur Respir J 2002;19:405–13.Ferrer M., Villasante C., Alonso J., et al. Interpretation of quality of life scores from the St George's Respiratory Questionnaire. Eur Respir J 2002;19:405–13.15. MVH Group. The measurement and valuation of health. Final report on the modelling of valuation tariffs. York Centre for Health Economics, 1995.MVH Group. The measurement and valuation of health. Final report on the modelling of valuation tariffs. York Centre for Health Economics, 1995.16. Domindo-Salvany A., Lamarca R., Ferrer M., et al. Health-related quality of life and mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002;166:680–5.Domindo-Salvany A., Lamarca R., Ferrer M., et al. Health-related quality of life and mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002;166:680–5.17. Gallefoss F., Bakke P.S., Kjaersgaard P. Quality of life assessment after patient educationGallefoss F., Bakke P.S., Kjaersgaard P. Quality of life assessment after patient educationin a randomized controlled study on asthma and chronic obstructive pulmonary disease. Am JRespir Crit Care Med 1999;159:812–7.18. Руководство по диагностике, лечению и профилактике бронхиальной астмы и одышки. Российское респираторное общество. Под ред. А.Г. Чучалина. М., 2005.Руководство по диагностике, лечению и профилактике бронхиальной астмы и одышки. Российское респираторное общество. Под ред. А.Г. Чучалина. М., 2005.19. Definition and classification of chronic bronchitis for clinical and epidemiological purposes. A report to the Medical Research Council by their Committee on the Aetiology of Chronic Bronchitis. Lancet 1965;1(7389):775–9.Definition and classification of chronic bronchitis for clinical and epidemiological purposes. A report to the Medical Research Council by their Committee on the Aetiology of Chronic Bronchitis. Lancet 1965;1(7389):775–9.20. Авдеев С.Н., Чучалин А.Г. Одышка: механизмы развития, оценка и лечение: Пособие для врачей. М., 2002.Авдеев С.Н., Чучалин А.Г. Одышка: механизмы развития, оценка и лечение: Пособие для врачей. М., 2002.21. Dyspnea. Mechanisms, assessment, and management: A Consensus Statement. American Thoracic Society. Am J Respir Crit Care Med 1999;159:321–40.Dyspnea. Mechanisms, assessment, and management: A Consensus Statement. American Thoracic Society. Am J Respir Crit Care Med 1999;159:321–40.