The ClinicianThe ClinicianКлиницист1818-83382412-8775Publishing House ABV Press11510.17650/1818-8338-2011-2-13-19REVIEWОБЗОРBACK PAIN ASSOCIATED WITH INTERVERTEBRAL DISK DEGENERATION: MORPHOLOGICAL, GENETIC AND CLINICO-INSTRUMENTAL ASPECTSБОЛЬ В СПИНЕ, АССОЦИИРОВАННАЯ С ДЕГЕНЕРАЦИЕЙ МЕЖПОЗВОНКОВОГО ДИСКА: МОРФОЛОГИЧЕСКИЕ, ГЕНЕТИЧЕСКИЕ И КЛИНИКО-ИНСТРУМЕНТАЛЬНЫЕ АСПЕКТЫShostakN. A.ШостакН. А.
Russian Federation

Acad. A.I. Nesterov’s Therapy Department

Кафедра факультетской терапии им. акад. А.И. Нестерова

PravdyukN. G.ПравдюкН. Г.
Russian Federation

Acad. A.I. Nesterov’s Therapy Department

Кафедра факультетской терапии им. акад. А.И. Нестерова

pravda547@yandex.ruShvyrevaN. M.ШвыреваН. М.
Russian Federation

Acad. A.I. Nesterov’s Therapy Department

Кафедра факультетской терапии им. акад. А.И. Нестерова

EgorovaV. A.ЕгороваВ. А.
Russian Federation

Acad. A.I. Nesterov’s Therapy Department

Кафедра факультетской терапии им. акад. А.И. Нестерова

Russian State Medical University, Ministry of Health and Social Development of RussiaГОУ ВПО РГМУ Минздравсоцразвития России150420115213191707201417072014Copyright ©; 2011, Shostak N.A., Pravdyuk N.G., Shvyreva N.M., Egorova V.A.Copyright ©; 2011, Шостак Н.А., Правдюк Н.Г., Швырева Н.М., Егорова В.А.2011Shostak N.A., Pravdyuk N.G., Shvyreva N.M., Egorova V.A.Шостак Н.А., Правдюк Н.Г., Швырева Н.М., Егорова В.А.https://creativecommons.org/licenses/by/4.0https://klinitsist.abvpress.ru/Klin/article/view/115

Degenerative spine disease is one of the causes of back pain. Clinical types of pain and severity of inflammatory changes in the vertebral bodies depend on the activity of pro-inflammatory cytokines. Rate of development and progression of degenerative changes in the spine structures is genetically determined. Therapy of pain syndrome associated with a degenerative disc disease may include use of methods to restore damaged intervertebral disc structures, and also use of different combinations of anti-inflammatory and analgesics therapy.

Одной из причин возникновения боли в спине является дегенеративное поражение позвоночника. Клинические варианты болевого синдрома и выраженность воспалительных изменений в телах позвонков зависят от активности провоспалительных цитокинов. Скорость развития и прогрессирования дегенеративных изменений структур позвоночного столба генетически детерминирована. Терапия болевого синдрома, ассоциированного с дегенеративной болезнью диска, может включать применение методов восстановления структуры поврежденного межпозвонкового диска, а также использование различных комбинаций противовоспалительных и анальгетических средств.

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