Email this article ENDOTHELIUM LESION MARKERS AND THROMBOCYTE AGGREGATION IN CHRONIC HEPATITIS AND HEPATIC CIRRHOSIS
- Authors: Shchekotova A.P.1
-
Affiliations:
- SBEI HPE Perm State Academy of Medicine named after Academician E.A.Wagner of Ministry of Health and Social Development of Russia
- Issue: Vol 6, No 1 (2012)
- Pages: 31-35
- Section: ORIGINAL INVESTIGATIONS
- Published: 15.07.2014
- URL: https://klinitsist.abvpress.ru/Klin/article/view/66
- DOI: https://doi.org/10.17650/1818-8338-2012-1-31-35
- ID: 66
Cite item
Full Text
Abstract
Aim — to estimate endothelium lesion, quantity and thrombocyte aggregation function correlation in viral chronic hepatitis C (CHC) and hepatic cirrhosis (HC).
Materials and methods. 50 CHC patients and 28 HC patients were examined. Using IFA method the total nitric oxide, endothelin‑1, vasculoendothelial growth factor levels, Willebrand factor (vWF) activity were investigated, blood plasma desquamated endotheliocyte (DEC)
number was calculated with Hladovec method, 1978, thrombocyte aggregation (TA) with ADP, collagen, ristocetine was determined.
Results. DEC and vWF demonstrated correlation in CHC (p = 0.014) and HC (p = 0.000004). In HC patients reliable correlation of all the investigated indices of endothelium lesion with the thrombocyte number and TA was detected, but in CHC patients no correlations were revealed. Thus, significant elevation of TA with ristocetine was noted only in CHC. Decrease in thrombocyte amount among CHC patients and,
especially in HC, and heightened vWF activity could change true TA indices. The corrected TA, whose indices in hepatic diseases significantly
increased, was calculated taking into account the correction factor vWF / thrombocytes that in CHC did not differ from that of healthy patients and in HC was essentially higher.
Conclusion. Endothelium dysfunction markers in CH and HC demonstrate correlation with thrombocyte reduction and TA elevation. Determination
of corrected TA permits to reveal disturbances of thrombocyte hemostasis in the form of elevated aggregation in all CHC and HC patients.
About the authors
A. P. Shchekotova
SBEI HPE Perm State Academy of Medicine named after Academician E.A.Wagner of Ministry of Health and Social Development of Russia
Author for correspondence.
Russian Federation
References
Supplementary files
