Restoration of bladder function after cerebral strokes

Aim. To evaluate the effectiveness of the drug “Polypeptide from the brain of pig embryos” in correction of imperative urinary incontinence after cerebral ischemic stroke.
Material and methods. The trial was randomized, controlled, blinded with concealment through envelopes. The trial included 170 patients in the early recovery period after cerebral ischemic stroke who were at the second and third stages of medical rehabilitation. Patients in the main group (n = 89) received the domestic drug “Polypeptide from the brain of pig embryos” 1 ml (0.1 mg) subcutaneously daily for 10 days, while those in the control group (n = 81) received only drugs for secondary prevention of ischemic stroke. The groups were comparable in terms ofsex, age, medical and biological parameters, subtypes of cerebral ischemic stroke, period of ischemic stroke, neurologic deficit, severity of cognitive and emotional disorders, and urological symptoms. Research methods included analysis of complaints and history ofthe patients, clinical somatic and neurologic examinations, evaluation of neuro-urologic symptoms using questionnaires, laboratory diagnostics, ultrasound of the urinary tract, urodynamic examinations, and follow-up for 6 months.
Results. During the examination, pollakiuria was diagnosed in 69 (77.5 %) patients in the main group and 64 (79.0 %) in the control group, episodes of imperative urinary incontinence were diagnosed in 43 (48.3 %) patients in the main group and 38 (46.9 %) in the control group, urinary urgency was diagnosed in 41 (46.1 %) patients in the main group and 37 (45.7 %) in the control group; nocturia was diagnosed in 28 (31.5 %) patients in the main group and 25 (30.9 %) in the control group. The intensity of urinary urgency in points was 3.2 in the main group and 3.1 in the control group; the frequency of daytime pollakiuria was 12 ± 0.8 in the main group and 12 ± 0.7 in the control group; episodes of imperative urinary incontinence were 5 ± 0.6 in the main group and 5 ± 0.5 in the control group; cases of night awakenings/trips/night urination in absorbent underwear were 3 ± 0.9 in the main group and 3 ± 0.7 in the control group. Statistically significant differences were obtained in the main group in the form of a decrease in the number of patients with urinary urgencies, daytime pollakiuria, episodes of imperative urinary incontinence compared to the baseline level (p <0.05).
Conclusion. The use of “Polypeptide from the brain of pig embryos” demonstrated a decrease in the frequency of imperative urges, pollakiuria, imperative urinary incontinence, nocturia and the severity of the imperative urge in patients with ischemic stroke.