Email this article VASCULAR REMODELING IN HYPERTENSION: ANGIOGENESIS FEATURES
- Authors: Haisheva L.A.1, Shlyk S.V.1, Pleskachev A.S.1, Makarenko E.S.1
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Affiliations:
- Russia Rostov State Medical University
- Issue: Vol 6, No 1 (2012)
- Pages: 26-30
- Section: ORIGINAL INVESTIGATIONS
- Published: 15.07.2014
- URL: https://klinitsist.abvpress.ru/Klin/article/view/65
- DOI: https://doi.org/10.17650/1818-8338-2012-1-26-30
- ID: 65
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Abstract
Aim — cross-sectional study of changes in various segments of the vascular bed in arterial hypertension (AH), defining the role of inducers and inhibitors of angiogenesis in these processes.
Materials and methods. The study included 99 patients with arterial hypertension of I–II degree, average age of 63.2 ± 2.6 years, disease
duration 9.2 ± 7.2 years.
Results. It was found that patients with arterial hypertension have disorders in all segments of vascular bed: endothelial dysfunction (high
vWF), microcirculatory disorders, and increased pulse wave velocity (PWV) of elastic-type vessels. The level of angioginesis factors does
not depend on such parameters as gender, age, body mass index. Smoking and duration of hypertension influence on vascular endothelial
growth factor raise and endostatin levels are higher in patients with family history of cardiovascular diseases. Duration of disease is directly
correlated with microcirculatory disorders and the PWV, correlation between microcirculatory disorders and pulse wave velocity indicate
their common processes.
About the authors
L. A. Haisheva
Russia Rostov State Medical University
Author for correspondence.
Email: katelnitskay@mail.ru
Russian Federation
S. V. Shlyk
Russia Rostov State Medical UniversityRussian Federation
A. S. Pleskachev
Russia Rostov State Medical UniversityRussian Federation
E. S. Makarenko
Russia Rostov State Medical UniversityRussian Federation
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