Expanding the possibilities of treatment and prevention of venous thromboembolic complications in cancer patients. The role of oral anticoagulants

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Abstract

Improving the quality of care for patients with oncological diseases due to the improvement of methods of chemoradiotherapy and surgical interventions, accessibility and modernization of diagnostic potential, is accompanied by a steady increase in the frequency of venous thromboembolic complications, which occupy one of the leading places among the causes of death.

Patients with oncological diseases are subject to various risk factors for thromboembolic complications, which are caused by the presence of a malignant neoplasm, due to the development of many coagulation abnormalities, initiating not only an increased tendency to thrombosis, but also a tendency to bleeding. Cancer-associated venous thrombosis, growing out of the framework of certain medical specialties, act as comorbid pathological conditions that require an interdisciplinary approach in developing rational methods of prevention and treatment. Improving the understanding of the pathophysiological mechanisms of venous thrombosis in cancer patients contributes to the development of modern methods of prevention and treatment, among which anticoagulant therapy plays a dominant role. The appearance of oral anticoagulants on the pharmaceutical market, the effectiveness and safety of which is confirmed by a series of randomized clinical trials, opens up new prospects for improving the quality of life and long-term survival in patients with malignant neoplasms.

About the authors

R. A. Bredikhin

Kazan State Medical University, Ministry of Health of Russia; Interregional Clinical and Diagnostic Center

Author for correspondence.
Email: rbredikhin@mail.ru
ORCID iD: 0000-0001-7160-3333

Roman Aleksandrovich Bredikhin

49 Butlerova St., Kazan, 420012

12a Karbysheva St., Kazan, 420101

Russian Federation

R. V. Akhmetzyanov

Kazan State Medical University, Ministry of Health of Russia; Interregional Clinical and Diagnostic Center

ORCID iD: 0000-0001-8146-2263

49 Butlerova St., Kazan, 420012

12a Karbysheva St., Kazan, 420101

Russian Federation

R. N. Khayrullin

Interregional Clinical and Diagnostic Center

ORCID iD: 0000-0002-2160-7720

12a Karbysheva St., Kazan, 420101

Russian Federation

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Copyright (c) 2022 Bredikhin R.A., Akhmetzyanov R.V., Khayrullin R.N.

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