Email this article THE ROLE OF CYTOKINE SYSTEM RANKL-RANK-OPG AND CATHEPSIN K IN THE PATHOGENESIS OF OSTEOPOROSIS: ACHIEVEMENTS AND PERSPECTIVES IN THE TREATMENT OF DISEASE
- Authors: Sagalovsky S.1, Kunze P.1, Schönert M.1
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Affiliations:
- Median Klinik, Bad Lausick, Germany
- Issue: Vol 6, No 2 (2012)
- Pages: 9-16
- Section: REVIEW
- Published: 15.10.2015
- URL: https://klinitsist.abvpress.ru/Klin/article/view/213
- DOI: https://doi.org/10.17650/1818-8338-2012-6-2-9-16
- ID: 213
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Abstract
The article presents review of literature dedicated to the contemporary view on the cellular-molecular mechanisms of the bone remodeling and pathogenesis of the osteoporosis. The discovery of the cytokine RANKL-RANK-OPG system and significant role of the cathepsin K in process bone remodeling has made progress in understanding the mechanisms development disease and possible to development drugs of the new generation – denosumab, a fully human RANKL monoclonal antibody and inhibitor cathepsin K odanacatib that inhibits of the bone resorption.
About the authors
S. Sagalovsky
Median Klinik, Bad Lausick, Germany
Author for correspondence.
Email: stanislav.sagalovsky@median-kliniken.de
Department of Orthopedics Germany
P. Kunze
Median Klinik, Bad Lausick, GermanyDepartment of Orthopedics Germany
M. Schönert
Median Klinik, Bad Lausick, GermanyDepartment of Orthopedics Germany
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