Email this article PREVENTION OF ANTRACYCLIN ANTIBIOTIC DOXORUBICIN СARDIOTOXICITY: A ROLE OF ACE-INHIBITOR PERINDOPRIL
- Authors: Pravdivtseva E.V.1, Poteshkina N.G.1, Svanadze A.M.1, Rilskiy D.S.1
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Affiliations:
- The Russian National Research Medical University named after N.I.Pirogov
- Issue: Vol 5, No 3 (2011)
- Pages: 55-60
- Section: ORIGINAL INVESTIGATIONS
- Published: 17.07.2014
- URL: https://klinitsist.abvpress.ru/Klin/article/view/102
- DOI: https://doi.org/10.17650/1818-8338-2011-3-55-60
- ID: 102
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Abstract
Aim – to study how anthracyclines influence on cardiovascular system in patients with lymphomas and whether angiotensin-converting enzyme inhibitor Perindopril is cardioprotective in these patients.
Subjects and methods. 26 patients with Hodgkin’s disease and non-Hodgkin’s lymphomas were followed before and after treatment with
doxorubicin. 12 of these patients with arterial hypertension received angiotensin-converting enzyme inhibitor Рerindopril, 10 mg/d, during
treatment with doxorubicin. Cardiological evaluation was performed before and the next day after chemotherapy. Average dose of Doxorubicin was 34,99 ± 13,23 mg/m2.
Results. In patients receiving anthracyclines deceleration time DT increased significantly, a significant reduction in heart rate (HR), cardiac
output (CO) and cardiac index (CI) were observed also (рDT = 0,037, pHR = 0,048, рСО = 0,007, рCI = 0,007). In patients simultaneously
treated with Perindopril these parameters were not statistically different (рDT = 0,92, pHR = 0,22, рCO = 0,35, рCI = 0,39).
Conclusion. Administration of anthracyclines (average dose of Doxorubicin 34,99 ± 13,23 mg/m2) leads to DT of the left ventricle and
reduction in HR, CJ and CI. Simultaneous treatment with Perindopril in patients receiving anthracyclines preserves DF and prevents heart hemodynamics abnormalities.
About the authors
E. V. Pravdivtseva
The Russian National Research Medical University named after N.I.Pirogov
Author for correspondence.
Email: katiku@yandex.ru
Russian Federation
N. G. Poteshkina
The Russian National Research Medical University named after N.I.PirogovRussian Federation
A. M. Svanadze
The Russian National Research Medical University named after N.I.PirogovRussian Federation
D. S. Rilskiy
The Russian National Research Medical University named after N.I.PirogovRussian Federation
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